Phases of Wound Healing Essay examples

Phases of Wound Healing Essay examples

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(A)Wound healing is a biological process occurring in the human body. In this lecture we had discussed about both acute and chronic wounds. An acute wound is an injury to the skin that occurs suddenly rather than over time. It heals at a predictable and expected rate according to the normal wound healing process. The chronic wounds do not heal in an orderly set of stages and in a predictable amount of time the way most wounds do.

The normal wound healing process mainly consists of four main stages being haemostasis, inflammation, proliferation or new tissue formation, and tissue remodeling or resolution. For a wound to heal well the above mentioned stages should occur in a sequential and orderly manner. Disturbances, abnormalities and delays in any of the above stages may lead to impaired healing or even chronic wounds. In adults, this process of normal healing takes place in the following steps (1)rapid haemostasis (2)appropriate inflammation (3)mesenchymal cell differentiation, proliferation, and migration to the wound site (4)suitable angiogenesis (5)prompt re-epithelialization and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue.

Immediately after wounding, the first phase of hemostatsis sets in motion with vascular constriction which restricts the blood flow in the blood vessels followed by the platelets plug formation which creates a temporary blockage of blood flow and then coagulation takes place with fibrin clot formation. The clot and surrounding tissue release pro-inflammatory growth factors and cytokines such as transforming growth factor (TGF)-13, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF).
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...h scaffolding and other methods may increase cell viability which is major backdrop in stem cells use.





References:
1. Stem Cells and Healing: Impact on Inflammation: William J. Ennis,1 " 2' * Audrey Sui, 2 and Amelia Bartholomew3.
2. Factors Affecting Wound Healing : S. Guo and L.A. DiPietro*.
3. Wound repair and regeneration:Geoffrey C. Gurtner1, Sabine Werner2, Yann Barrandon3,4 & Michael T. Longaker1
4. Current Status of the Use of Modalities in Wound Care: Electrical Stimulation and Ultrasound Therapy: William J. Ennis, D.O.,M.B.A.,Claudia Lee, M.P.T.,Malgorzata Plummer, M.D.,Patricio Meneses, Ph.D.
5. Exploring the role of stem cells in cutaneous wound healing: Katherine Lau, Ralf Paus, Stefan Tiede.
6. http://en.wikipedia.org/wiki/Negative-pressure_wound_therapy
7. Promotion of wound healing with electrical stimulation: Kloth LCMcCulloch JM

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