(A)Wound healing is a biological process occurring in the human body. In this lecture we had discussed about both acute and chronic wounds. An acute wound is an injury to the skin that occurs suddenly rather than over time. It heals at a predictable and expected rate according to the normal wound healing process. The chronic wounds do not heal in an orderly set of stages and in a predictable amount of time the way most wounds do.
The normal wound healing process mainly consists of four main stages being haemostasis, inflammation, proliferation or new tissue formation, and tissue remodeling or resolution. For a wound to heal well the above mentioned stages should occur in a sequential and orderly manner. Disturbances, abnormalities and delays in any of the above stages may lead to impaired healing or even chronic wounds. In adults, this process of normal healing takes place in the following steps (1)rapid haemostasis (2)appropriate inflammation (3)mesenchymal cell differentiation, proliferation, and migration to the wound site (4)suitable angiogenesis (5)prompt re-epithelialization and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue.
Immediately after wounding, the first phase of hemostatsis sets in motion with vascular constriction which restricts the blood flow in the blood vessels followed by the platelets plug formation which creates a temporary blockage of blood flow and then coagulation takes place with fibrin clot formation. The clot and surrounding tissue release pro-inflammatory growth factors and cytokines such as transforming growth factor (TGF)-13, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF).
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...h scaffolding and other methods may increase cell viability which is major backdrop in stem cells use.
1. Stem Cells and Healing: Impact on Inflammation: William J. Ennis,1 " 2' * Audrey Sui, 2 and Amelia Bartholomew3.
2. Factors Affecting Wound Healing : S. Guo and L.A. DiPietro*.
3. Wound repair and regeneration:Geoffrey C. Gurtner1, Sabine Werner2, Yann Barrandon3,4 & Michael T. Longaker1
4. Current Status of the Use of Modalities in Wound Care: Electrical Stimulation and Ultrasound Therapy: William J. Ennis, D.O.,M.B.A.,Claudia Lee, M.P.T.,Malgorzata Plummer, M.D.,Patricio Meneses, Ph.D.
5. Exploring the role of stem cells in cutaneous wound healing: Katherine Lau, Ralf Paus, Stefan Tiede.
7. Promotion of wound healing with electrical stimulation: Kloth LCMcCulloch JM
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- Medical authorities often describe wound healing in terms of overlapping phases that occur in the days, weeks and months following an injury. These phases are hemostasis, inflammation, proliferation and maturation. Hemostatsis is commonly included as a component of the inflammation phase. It is the body’s attempt to quickly stop bleeding without unnecessarily disrupting blood flow. Injuries are unique and the healing process for those injuries varies depending on a number of factors including the depth, size, type and location of the wound.... [tags: hemostasis, inflammation, proliferation]
897 words (2.6 pages)
- Introduction Advances in science over the centuries can be seen in various areas of medicine. One such area is in the treatment and healing process of wounds. In the past, wounds were treated and left to heal naturally where scar formation was common. However, times have changed and people are more concerned with their physical looks than they were two decades ago. The rise in plastic surgery operations is a clear indication of this increase in physical awareness. This change has led to medical research aimed at discovering ways in which wounds after treatment can be made to heal without forming scars.... [tags: Treatment, Healing Process]
1322 words (3.8 pages)
- ... Some common clean-contaminated procedures include ear surgery on an infected ear, the removal of pins or wires from previous surgeries as well as Cesarean Sections that include a rupture before the procedure is preferred. Class II – Contaminated wounds. Infection rate 15-20%. The wound is considered contaminated if it has a foreign object inside it. These classes of wounds are often visibly more inflamed than the skin around the wound site. A large amount of fluid is present. Many Class II wounds are operation wounds that are a side effect or mistaken in technique, including those that become infected with bodily fluids.... [tags: skin, surgory, infection]
746 words (2.1 pages)
- ... The first is primary intention also known as first intention wound healing. This wound is a clean wound that is closed (S. Zinn, n.d.) It results in low infection rates postoperatively (Mulholland and Doherty, 2006, p.135). Next, is second intention wound healing or spontaneous wound healing (S. Zinn, n.d.). This wound is left open to heal by the body’s natural ability of epithelialization and formation of granulation tissue (Mulholland and Doherty, 2006, p. 135). It is often used for an infected or contaminated wound.... [tags: contamination, stages, complications]
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- Introduction. This report will discuss the risk of impaired wound healing, amongst patients in the community. Patients may be at risk due to increased age, malnutrition and underlying medical conditions (Timmons, 2003, White, 2008). However, this report concerns with patients’ knowledge deficit about the importance of nutrition, which may be the risk factor (Casey, 1998, Dealey, 2005, Timmons, 2003). In this respect, a management package in the form of a leaflet aimed at these patients has been prepared, (see appendix), which may improve patients’ knowledge.... [tags: Medicine]
1200 words (3.4 pages)
- The management of wound healing in various health care settings can vary according to what treatment is performed, in our scenario a patient has come to us in regards to a complication that has occurred after a resurfacing procedure. This essay will discuss the procedure that has occurred and the issues and implications surrounding the procedure in terms of infection control. How the wound was created and what should have occurred during the repair process and what isn’t expected to occur. Possible causes of delayed wound healing will also be looked at and how we expect to manage in this situation, we will also discuss how we could prevent this from reoccurring.... [tags: Health, Treatment]
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- ... Dirty-contaminated (Class IV) is present when a traumatic open would has already had an infection present. When it comes to wound healing there are three different types: First Intention, Second Intention, and Third Intention ("Healing and Wound Classification", 2007, p. 26, 28, 30, and 32). First intention healing is the best when talking about simplicity. An example of this would be a normal surgical incision that is sutured and heals normally without complications. Second intention occurs when large wound cannot be close appropriately usually due to removal of tissue from the wound.... [tags: contamination, infection, complications]
562 words (1.6 pages)
- In the reading, “Slowing of wound healing by Psychological Stress,” a journal by Janice K. Kiecolt-Glaser, Phillip T. Marucha, William B. Malarkey, Ana M. Mercado, and Ronald Glaser. In the journal, the authors discuss the relationship between stresses and the impact that it has on people immune system. Can being stress in general can have an impact on the way we fight a cold. Could future problem with the immune system effect the way we recover from surgery, have more harm on our healing on cut.... [tags: stress, immune, system, surgery]
575 words (1.6 pages)
- ... Macrophages are activated by endotoxins released by bacteria; cytokines such as interferon-γ (IFN-γ) secreted by sensitized T lymphocytes; mediators produced during acute inflammation and also extracellular matrix (ECM) proteins such as fibronectin. Once macrophages are activated, it secretes a variety of biologically active products, for examples, reactive oxygen species (ROS), cytokines such as IL-1 and TNF, and arachidonic acid, at which may cause tissue injury and fibrosis if left unchecked. • Lymphocytes: Lymphocytes, both T lymphocytes and B lymphocytes, migrate to the inflammatory site with the help of cytokines and adhesion molecules.... [tags: injury, leukocytes, blood]
1741 words (5 pages)
- The Healing Wound It’s a beautiful morning at our nation’s capital. Constitution Gardens is blooming with life. Flowers of red, yellow, and pink bob their heads in the gentle summer breeze. Wise old trees proudly oversee the grassy lawns, while twittering birds scamper about on their strong, sturdy limbs. People talk animatedly as they stroll in small groups along the brown, dusty paths. Children run and jump, stopping occasionally to make quick poses for parents’ snapping cameras. As we walk ahead, we notice a shape taking form on the horizon.... [tags: Vietnam Veterans War Memorial Essays]
1444 words (4.1 pages)