Pertussis, commonly known as whooping cough, is a highly contagious respiratory disease caused by a bacterium, Bordatella pertussis. In 2010 it affected 27, 5501 individuals and was responsible for 262 deaths in the United States. Bordatella pertussis colonizes in the cilia of the respiratory tract3 producing uncontrollable coughing with paroxysms (fits) followed with a high pitched intake of air creating a whoop sound, posttussive emesis (cough induced vomiting), and exhaustion.3 These symptoms can last up to 10 weeks.3 Adults can transfer Pertussis to infants who are not fully immunized, subsequently, they are at a greater risk and may have serious complications from Pertussis including pneumonia and death.4
As illustrated in the Figure 1.1 the epidemiologic triangle of pertussis, the agent is the bacterium, Bordatella pertussis, it is strictly a human pathogen and does not have an environmental or animal reservoir; however, adults/children with unrecognized pertussis are a reservoir for susceptible infant s and young children.5 Bordatella pertussis spread through respiratory droplets and are aerosolized by uncontrollable coughing of the infected individual.5 It can only survive outside of the human host for several days6; and, has an incubation period is 6 to 10 days within the host.5
Using a descriptive analysis on the Pertussis mortality data sets from the Center of Disease Control Wide-ranging Online Data for Epidemiologic Research (CDC Wonder), over a ten-year period (2000-2010), data demographic was gathered on race, age, sex, geographic distribution, and incidence rates. The data examined only deaths categorized as A37, Whooping Cough and including the subcategories A37.0 (due to Bordetella pertussis) A37.1 (due to Bord...
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...tain exemptions to a majority of immunizations conflicting with their beliefs.9 Moreover, those identified with the California pertussis outbreak were characterized as high socioeconomic status.9 Also, this community as a whole intentionally unvaccinated their children leading to a pertussis outbreak and endangered vulnerable population, infants.9
In conclusion, epidemiology of pertussis provides disease prevention by identifying the individuals, variants and/or causes. Also, these identifications enable public health officers in promoting pertussis vaccines which leads to directly preventing it. Furthermore, it prevents exposures to the pertussis bacterium to vulnerable population unvaccinated or undervaccinated infants/children. The methodology used by epidemiologist enables the immobilization of pertussis thereby prevent its mortality and epidemic proportions.
They pose a real health concern to the public. Those that haven’t been vaccinated pose a risk to others that aren’t vaccinated, babies that are too young to vaccinate, and those with a weak immune system. The growing number of unvaccinated families has become a growing concern for physicians. The Chicago Tribune reported, “Almost all physicians encounter parents refusing vaccines, according to a recent study.”5 The study also reports, “A small number of pediatricians — about one in five — have turned away unvaccinated families from their practices, said Dr. Sean O 'Leary, an associate professor of pediatrics at Children 's Hospital Colorado and lead author of the study.”
In the Frontline episode The Vaccine War, a progressively distressful debate ensues among many scientists and doctors within the public health system and an unnerving alliance of parents, politicians, and celebrities. The topic of debate is the overwhelming pressure parents feel to vaccinate their children and their right to decline such vaccinations. In several American neighborhoods, groups of parents have been exercising their right to refuse vaccinations, which has elevated anxiety on the return of vaccine-preventable diseases such as pertussis and measles. The reason such parents are denying their children various vaccines such as the MMR “triple shot” for measles, mumps, and rubella is because they are convinced that it is linked to autism, a link that has yet to be proven. Many of these parents are focused solely on their children, not taking into account that their decision may put the American populace at risk for disease. Such parents are not thinking about other members of society that vaccines don’t work for, and in certain adolescents the effects deteriorate, thus only when every person is immunized the “heard immunity” is successful.
Bordetella pertussis is a highly communicable agent and is transmitted person-to-person via airborne droplets or direct contact with discharges from the respiratory mucous membranes of an infected person. This small, gram-negative coccobacillus is non-motile, aerobic and fastidious. B. pertussis colonizes the respiratory tract including the mouth, nose, throat and beginning of the lungs of young children worldwide. The bacteria bind to ciliated cells in the respiratory mucosa by producing adhesions. Filamentous hemagglutinin on the cell surface and pertussis toxin (Ptx) both help the bacteria in binding. Filamentous hemagglutinin binds to the galactose residues on the glycolipid of the ciliated cells. Ptx, in its cell-bound form, binds to the glycolipid lactosylceramide, which is also found on the ciliated cells. Ptx binds to the surface of phagocytes as well, causing phagocytosis of the bacteria. This mechanism may lead to enhanced survival as an intracellular parasite. Adding to its many purposes, Ptx deregulates the host cell adenylate cyclase activity. The A subunit of this AB toxin, affects the G protein responsible for inhibiting adenylate cyclase. This leads to an increase in cyclic adenosine monophosphate (cAMP) creating detrimental metabolic changes in the host cells.
For the disease to occur, Bordetella pertussis evades the host immune system and is disseminate in the lower respiratory tract. Inhaled bacteria droplets then attach to the ciliated epithelial cells in the nasal-pharynx and trachea. It is at this point that Bordetella pertussis produces virulent factors that are classified into two; adhesins and toxins. Adhesins mediate bacterial attachment to the epithelial cells while toxins that mediate the host immune system. Adhesins include; filamentous haemagglutinin, fimbriae and pertactin while toxins include pertussis toxin, tracheal cytotoxin and adenylate cyclase toxin(1). To understand the role of these virulence factors in whooping cough disease, a mouse model has been used (2).
Pertussis: Pertussis also known as whopping cough is a highly contagious bacterial disease that causes an uncontrollable, severe coughing. It is a serious disease that can affect individual of all ages with severe complication resulting in permanent disability in infants and lastly death. The fact that this 7-months old baby stay up night, inability to sleep can make it hard to breathe. Burns, Cotter, Harvill, Hewlett, Merkel, Stibitz & Quinn explained that pertussis is an upper respiratory infection caused by the Bordetella pertussis bacteria in addition to the systemic manifestations such as “lympocytosis, dysregulated secr...
Poliomyelitis is a virus that infects the nerves of the spinal cord, and brain which leads to paralysis and or death (Piddock, 2004). Poliomyelitis is best known today as Polio, and Infantile Paralysis. Tonsillectomy polio would take over the lymph nodes in order to spread the infection throughout the body, leading to muscle paralysis in the limbs, and in some cases respiratory failure. Bulbar polio was a much more severe form, it affected the top of the spinal cord which caused paralysis and inability to swallow fluids (Rifkind, 2005). Polio was transmitted through ingesting materials contaminated by the virus found in feces. Children would play in public swimming pools, and ingest the contaminated water which lead to infection (Piddock, 2004). After the person ingested the virus, it would travel their intestinal tract, and eventually compromise their lymph nodes, making them unable to fight off the virus. Symptoms were like those of the flu, such as fever, headache, and upset stomach. The minority of people were able to let the virus run its course and it would be passed through their feces like any other virus. Others weren’t so lucky, those with compromised immune systems were unable to fight off the virus, the lymph nodes would fail to protect the nervous system causing paralysis once it reached the spinal cord (Piddock, 2004). Poliomyelitis has since then been eliminated in the United States because of the polio vaccine that is giv...
Although there is little news of it today, Diphtheria was one of the most common diseases found in the Eastern Region especially in Europe. Known as the “Strangling angel of children” it caused the death of many children by suffocation in Europe during the 17th century. Although today it is very rare to find this disease in the United States, this disease is commonly found in places where there is low hygiene or an unclean environment. Due to the modern understanding of the transmission and composition along with the development of a vaccine; it has brought us a long way of avoiding this disease.
Infection with C. perfringens as a food-borne illness is acquired from consumption of food or water that has come in contact with the bacterium. Some possibilities include unwashed fruits and vegetables, undercooked me...
Vaccines have been used to prevent diseases for centuries, and have saved countless lives of children and adults. The smallpox vaccine was invented as early as 1796, and since then the use of vaccines has continued to protect us from countless life threatening diseases such as polio, measles, and pertussis. The Center for Disease Control and Prevention (2010) assures that vaccines are extensively tested by scientist to make sure they are effective and safe, and must receive the approval of the Food and Drug Administration before being used. “Perhaps the greatest success story in public health is the reduction of infectious diseases due to the use of vaccines” (CDC, 2010). Routine immunization has eliminated smallpox from the globe and led to the near removal of wild polio virus. Vaccines have reduced some preventable infectious diseases to an all-time low, and now few people experience the devastating effects of measles, pertussis, and other illnesses.
This can be seen in the article Vaccine Controversies by Jane Lemons. “Public health officials say refusing to follow vaccine protocols allows diseases to spread rapidly as happened in December 2014 when a measles outbreak began at Disney Land and spread to seven states.” The measles outbreak from 2014 could have easily been avoided if all children who entered the park were indeed vaccinated. If the majority of children were vaccinated there would have been no possible way for the disease to spread. While it can't be denied, A lot of families do choose to vaccinate their children, there are still some who don't, this is seen in the article Vaccine Controversies by Jane Lemons. Although the vast majority of Americans continue to vaccinate their children, studies have found that as many as 1 in 10 parents are delaying or forgoing some or a; recommended vaccines for their children. Because some parents are delaying or forgoing all vaccinations more children are at risk of going under the influence of a fatal disease that could cut their lives too short. Fatal diseases have the ability to spread at unthinkable rates and vaccinations are used to combat these deadly diseases but if families refuse to vaccinate their children once fatal diseases could return at epidemic
Recent research shows that, there are three major means by which infections can be transmitted and they include direct transmission, indirect transmission and airborne transmission (Hinman,Wasserheit and Kamb,1995). Direct transmission occurs when the physical contact between an infected person and s susceptible person takes place (division of public health, 2011). An example is a health care worker who attends to an Ebola patient, without gloves, gown and mask plus forget to wash his or her hand with soap and hot water and or a person having flu without the use of mask or washes his hand after sneezing easily passes the infection to the other through hand shake or surface touch, living the bacteria there for another vulnerable person to also touch if the surface is not disinfected with bleach. Studies makes it clear that, the spreads takes effect when disease-causing microorganisms pass from the infected person to the healthy person through direct physical contact such as touching of blood, body fluids, contact with oral secretion, bites kissing, contact with body lesions and even sexual contact. However, measles and chicken pox are said to be conditions spread by direct
When hygienic conditions were poor polio attacked infants. The disease was spread by contaminated water and contact with fecal contamination. Many infants died when the conditions were poor. But as conditions improved the virus spread differently. It was spread more through playmates and family members, the contamination came from the nose and throat. By the early 1950s, twenty-five percent of paralytic cases occurred in people 21 years old or older.
Knowing the background information of viral pneumonia is vital in treating the disease in premature babies. Two scientists, Hippocrates and Maimonides, discovered pneumonia between 450 B.C. and 380 B.C as well as in the early nineteenth century. Hippocrates discovered pneumonia, but knew very little about it. On the other hand, Maimonides knew more about pneumonia and described it more thoroughly than Hippocrates. He described pneumonia as a disease causing acute fever, sticking pain in the side, short rapid breaths, and jagged pulse and cough (Meeks and Heit 492). “Viral pneumonia occurs more in young children than older adults because the bodies of young children have a harder time fighting off the virus and it is often caused by one of the several viruses: adenovirus, influenza, parainfluenza, and respiratory syncytial virus” (“Viral Pneumonia”). Viral pneumonia develops in children in about five to seven days, but bacterial pneumonia is more severe (McKenzie and et. al. 396). “Pneumonia affects approximately four million individuals each year. It is the most common cause of infectious death in the United States” (Neighbors and Jones 162). Viral pneumonia occ...
Those who choose not to vaccinate their children are endangering the health of those unable to be vaccinated themselves, such as infants, pregnant people, and the immunocompromised, by jeopardizing community immunity. According to vaccine.gov, a federal government website managed by the U.S. Dept. of Health and Human Services, community immunity or “herd immunity” occurs when “a critical portion of the community is immunized against a contagious disease, most members of the community are protected against that disease because there is little opportunity for an outbreak” (Community Immunity). An infographic featured in an NPR article entitled “How Vaccine Fears Fueled the Resurgence of Preventable Diseases” illustrated the rise in measles cases in Western Europe and of pertussis (whooping cough) cases in the U.S (Doucleff). In the first eight months of 2014, there were eighteen measles outbreaks, and six hundred cases of measles.
In Australia in the last ten years more then 137 known people have died and many more fallen very ill from contagious and infectious disease. Diseases such as diphtheria; tetanus, pertussis, poliomyelitis, measles, mumps rubella and Haemophilus influenzae, This is a great tragedy considering all these diseases are easily preventable by immunisation.