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Multiple sclerosis and how it affects people
Multiple sclerosis and how it affects people
Multiple sclerosis and how it affects people
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Multiple Sclerosis: Pathology of the Central Nervous System
Multiple Sclerosis is an autoimmune disease that commonly found in individuals between the ages of 20 and 40. While men with MS tend to have a faster progressing disease, women are more likely than men to develop it. MS comes in many forms due to the extent of the damage and the amount of lesions, along with how quickly it progresses. All of this collectively forms the MS community today and has resulted in new test methods and forms of treatment developed to both help relieve the symptoms and slow the progression of the disease. This research paper will go through what causes a person to develop MS, what is going on within the body that causes the symptoms people experience, both the objective and subjective findings of MS, as wells as pharmaceutical and natural treatment options.
Pathophysiology
Multiple Sclerosis is distinguished as a chronic autoimmune disease that results in the demyelination of the central nervous system. The ultimate problem is that myelin within the central nervous system becomes inflamed and scarred which has massive effects on the individual. Huether and McCance (2012) go into great detail about what Multiple Sclerosis is stating that it is a multifactorial disease, meaning that it results when a person is genetically prone to developing MS and then develops a virus in the nervous system. The demyelination and inflammation of the central nervous system is caused by plasma cells, B-lymphocytes, T-cells and proinflammatory cytokines and causes the scarring and the degeneration of axons, which is unfortunately irreversible.
Aside from the central inflammation caused by the disease, there is also injury throughout the CNS that is classified as ...
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...ve the symptoms associated with the disease. Other, natural options, for people include dietary changes, daily exercise, massage, and herbal remedies to name a few. There are still unknowns about MS, however, there have been great advancements in the diagnosing and treatment of multiple sclerosis that are helping individuals who have the disease every day.
References
Alnar, O. (2009). Treatment of Multiple Sclerosis. CNS and Neurological Disorders- Drug Targest, 8 (3), 167-174.
Cantorna, M. (2006). Vitamin D and its Role in Immunology: Multiple Sclerosis and Inflammatory Bowel Disease. Progress in Biophysics and Molecular Biology, 92, (1), 60- 64.
Huether, S. E., McCance, K. L. (2012). Understanding Pathophysiology. St. Louis, Missouri: Elsevier Inc.
Wilson, S., Giddens, J. Health Assessment for Nursing Practice. St. Louis, Missouri: Elsevier Inc.
Multiple sclerosis (MS) is a disease affecting the myelination of the central nervous system, leading to numerous issues regarding muscle strength, coordination, balance, sensation, vision, and even some cognitive defects. Unfortunately, the etiology of MS is not known, however, it is generally thought of and accepted as being an autoimmune disorder inside of the central nervous system (Rietberg, et al. 2004). According to a study (Noonan, et al. 2010) on the prevalence of MS, the disease affects more than 1 million people across the world, and approximately 85% of those that are affected will suffer from unpredictably occurring sessions of exacerbations and remissions. The report (Noonan, et al. 2010) found that the prevalence of MS was much higher in women than in men, and that it was also higher in non-Hispanic whites than in other racial or ethnic groups throughout the 3 regions of the United States that were studied.
WORLD HEALTH ORGANISATION, 1997. Tabular list of neurological and related disorders. In: WORLD HEALTH ORGANISATION, ed. Application of the International Classification of Diseases to Neurology. Canada: World Health Organisation, p. 153.
Multiple sclerosis (MS) is generally thought to be an autoimmune disease that attacks the myelin sheaths, or oligodendrocytes that cover nerve axons in the central nervous system (PubMed Health 2013). This immune response causes inflammation, which triggers immune cells to destroy axons “along any area of the brain, optic nerve, and spinal cord” (PubMed Health 2013). When the myelin sheath “is damaged, nerve signals slow down or stop” thus hindering the propagation of action potentials and limiting function (PubMed Health 2013).
The people with MS have to take a lot of Medication, and i mean a lot. So i’m just going to list a few. MS people will have to take a pill called Copaxone and this people will give the person a Myelin Protein. They people will take another pill called Gilenya and this will give them a dose of Flinglimomond. Another pill that they will have to take is called Tecfidor which keeps the inflammation down. The next thingn that they might have to take is Tysabri and that is when they put an IV in your arms about once about every for weeks SO thoes are some pills that they will have to take. The reason they have so many is there is no cure for this disease.
Multiple sclerosis - is an autoimmune disorder that affects the central nervous system including the spinal cord and brain.
(Marieb, 2016). Myelin is the protective coat surrounding and insulating the nerve fibers of CNS. Myelin is fatty tissue substance that if attacked by immune cells causing a short-circuits in the current so that the successive gaps are excited more and more slowly, and eventually impulse conduction ceases which resulted in various forms of symptoms (Marieb, 2016). The degradation could either be “by inflammation, stroke, immune disorder, metabolic disorders, or nutritional deficiencies” (Slomski, 2005). The target that immune cells are sensitized to attack remains
... damaged neurons. (Mayo clinic, 2014). This is called neuroplasticity, the ability for the nerves to compensate for damage caused by some outside force. Because of neuroplasticity physical training works to cure some of the paralysis left by the virus and allows us to walk again after the legs or another appendage is deformed or damaged.
The body’s inflammatory process is facilitated by T-cell and B-cell responses to autoantigens within the CNS. The inflammatory process that happens within the CNS causes declining changes in the brain. Some changes include the axonal loss and immobilizing neurological damages. The remaining damage that transpires is irreversible and permanent in the brain and spinal cord. The symptoms of MS depend on the type and the severity of the disease. If the type and severity of the disease is severe then the symptoms will be more extreme. Some of the more common symptoms that are experienced include sensory symptoms; like numbness, tingling or pain, fatigue, visual disturbances, elimination problems like frequency or urgency and depression. There are many methods to diagnosing MS. There has been an increase in treatment options available and they are continuously testing new drugs yearly.
Primarily, the term MS refers to a chronic disorder that attacks the central nervous system (CNS). It is most common in temperate continents such as Europe and Australia with Asiatic and African continents having a lower risk of the disease (Wiley Online Library, 2013). A search organised by the Multiple Sclerosis Society (2013) has estimated that there are 127,000 people living with MS in the United Kingdom. Further research by Chipps, Clanin, and Campbell (1992, pp. 158-167) shows that MS disorder more likely affects women than men with its symptoms occurring between the ages of 20 and 40 in most cases and is quite uncommon in childhood and old age. The nerve cells known as neurons in the brain constantly transmit and receive signals. They invoke emotions, activities and cognition that constitute the day to day experiences of humans. Under normal circumstances, these signals travel on a protected insulation path known as the myelin sheath. This insulation is vital as it enables signals to reach their target. In Multiple Sclerosis, the myelin sheath gets disintegrated causing the nerve fibre to be damaged leading to a disruption in the abili...
The etiology of the disease is not yet known. There is a discussion that there is action of one or more exogen factors, which after a long latent period trigger the disease in genetically receptive people. MS is characterized by a geographical and demographical spread, with frequency going up when moving away from the equator and again going down in the polar regions. Approximatly 30/100000 people have the disease globally.
Multiple sclerosis is a chronic disease of the central nervous system. It is understood as an autoimmune disease, a condition where the body’s immune system mistakenly attacks normal tissues. In Multiple Sclerosis, the patient’s own cells & antibodies attack the fatty myelin sheath that protects and insulates nerve fibres in the brain and spinal cord, the two components of the CNS. This ultimately causes damage to the nerve cells and without the insulation the myelin sheath provides, nerve communication is disrupted. Hence, Multiple Sclerosis is characterized by symptoms that reflect central nervous system involvement (Luzzio, 2014).
Physical and occupational therapy may also help. Multiple sclerosis is not a fatal disease. Most people with MS have a normal or near-normal life span and usually die from the same conditions that affect general population (heart disease, cancer). Multiple Sclerosis symptoms can negatively affect the quality of life. Suicide rates among patients with multiple sclerosis are higher than average. The majority of patients with MS do not become severely disabled. Women tend to have a better outlook than men. MS has long been known, yet diagnosis remains difficult due to the complexity of the disease and its wide array of signs and symptoms. Treating MS still relies on symptomatic relief, but therapeutic advances in the form of DMDs have shown promising
Patients whose lesion is in the Cerebrum & Cerebellum will experience loss of balance and coordination, difficulty speaking, and frequent limb trembles. Speech difficulties vary from slurred words, long pause between words, and swallowing problems. Patients whose lesion is in the Motor nerve tracts will experience weakened and stiffened muscles, blurred vision or vision impaired, and urinary problems. Weakened and stiffened muscles causes walking disabilities and painful feeling of muscle spasms in 6 to 10 people. Patients whose lesion is in the Sensory nerve tract will experience sensory alternations, fatigue, cognitive and emotional dysfunction, and loss of sexual interest. Difference sensations experienced are numbness, itching, burning, stabbing, or tearing pains.
With motor neurone disease it attacks the nerves, in the brain and spinal cord. This means messages gradually stop reaching muscles, which leads to weakness and wasting. In the case study the
This is a neurodegenerative disease, meaning it results in progressive loss or death of neurons. It often starts off with effecting simple motor skills like writing and holding things, after a few months usually patients start losing the ability to walk, talk, or move any of their limbs. Although the brain trauma is what causes it, ALS has little-no-effect on the brain. This fatal disease is typically diagnosed around age 60 and most patients are given about 3-5 years to live after being diagnosed. It has been found that 10% of cases are shown as genetic. It was brought to attention that athletes were beginning to get diagnosed with ALS at a younger age than most. After extensive research in the early 2000’s, Brain Analyst, Dr. Mckee ran tests and finally came to the conclusion that the toxic proteins in the brains of ALS patients were coming from repeated blows to the head. It was then made evident why so many athletes in contact sports such as football, soccer, boxing, etc… were being diagnosed at such a young age and more frequently than