New methods for identification and treatment of cancer cells are continuing to be researched. Colon cancer, one of the leading causes of cancer death in the United States, has been used as the choice for the cancer to identify and treat in certain studies. Through previous experiments, treatments for people with colon cancer have been utilized, but still present issues associated with the treatment is the proper identification of cancer cells and the high toxicity associated with some of the treatments and the effect on the human body. Research into procedures to reduce the identification time of cancer cells and lower the exposure to toxic chemicals in the body led to scientists modifying the delivery of the identification markers and treatments with nanotechnology.
Nanoparticles are seen as a viable solution to these problems and its use with identification of cancer cells and treatments were researched and reported to be analyzed for future use. Nanoparticles have been shown to be at times 20nm in length2 and have a higher effectiveness for diffusing encapsulated treatments. Up to 85% effectiveness has been reported in some cases2. The small size of nanoparticles also allows the ability to control what interactions take place by what is encapsulated or what is used to encapsulate the particle. The use of nanoparticles to identify and treat cancer cells were reported by two studies published in Nanoletters and Cancer Prevention Research.
The use of nanoparticles as labeling agents in immunoassays, which are tests that use antibodies to detect specific molecules, offers an improvement in sensitivity over traditional enzyme or dye labeling agents. When combined with specific antibodies, it was reported that nanoparticles can ...
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... the two compounds required to affect the cancer cells. The information shows that nanoparticles are a viable target delivery system for treatment of cancer cells. Nanoparticles require lower dosage amounts to be a successful treatment option and can be used for targeted delivery. The possibility of those compounds becoming option capable for use in chemoprevention allows for further developments in those compounds to be done.
Works Cited
1. Chaudhary, A.; Sutaria, D.; Huang, Y.; Wang, J.; Prabhu, S., Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system. Cancer prevention research 2011, 4 (10), 1655-64.
2. Maltez-da Costa, M.; de la Escosura-Muniz, A.; Nogues, C.; Barrios, L.; Ibanez, E.; Merkoci, A., Simple monitoring of cancer cells using nanoparticles. Nano letters 2012, 12 (8), 4164-71.
In this experiment, both BALB/c and C3H mice are induced with azoxymethane (AOM) and dextran sodium sulphate (DSS). The inflammation is caused by the administration of dextran sodium sulphate to the drinking water of the mice. While azoxymethane induction plays a role in the development to colon cancer. In this project, the development of colon cancer through the inflammation pathway is being researched. The process first starts with the of inflammation foci. Over time, it develops into hyperplasia due to the increasing capacity of cell proliferation.
...ozzi E, Biffoni M, Todaro M, Peschle C, et al. Identification and expansion of human colon-cancer-initiating cells. Nature. 2007;445(7123):111-5.
Pinto Reis C., Neufeld RJ., Ribeiro AJ., & Veiga F., 2006. Nanoencapsulation I. Method for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2, 9-21
Amandi Hiyare: Before forming my research question, I had a discussion with my research project coordinator “Lisa Pope” who told me that the Flinders nanotechnology research team has been developing microbial catheters. Then on Monday I had an interview with Professor Joe Shapter who told me that your team was leading this project. So I was wondering whether you would be able to provide me with some detailed information about this innovation?
U.S. Congress, Office of Technology Assessment. 1990. Unconventional Cancer Treatments, OTA-H-405. Washington, D.C.: U.S. Government Printing Office.
Wang, K., Wu, X., & Huang, J. (2013, February 28). Cancer stem cell theory: therapeutic implications for nanomedicine. Retrieved December 12, 2013, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589204/
Cancer in one way or another touches all of us, whether as a patient or through the diagnosis of the people you love around you. Millions of patients who are faced with cancer are depending on oncologists everywhere to cure cancer so others will not suffer like they had to. Optimistically, sooner rather than later this international problem will come to an end. There are a number of drug companies that have been coming out with cancer treatment drugs. “Oncology has been one of the hottest and most active therapeutic areas for drug development, drug makers may want to take note of a finding that new cancer drugs have proven far more difficult to gain approval than medicines for infectious and autoimmune diseases.” (nature.com) Unfortunately, these drugs cannot cure the cancer but it sure makes it a load easier o...
Drug peak has disappeared in XRD of Nanoparticle 3 which probably may be due to conversion of Tamoxifen citrate from crystalline state to amorphous state or dissolution during the heating involved in the preparation of solid lipid nanoparticle or may be another phenomenon is drug may be present in polymeric amorphous phase. (Fig
“Since 1990, over 6 million Americans have died of cancer, more than the combined casualties from the Civil war, WWII, and the Vietnam and Korean conflicts combined” (Faguet, p. 5). According to American Cancer Society projections, there were 1,529,560 new cases of cancer in 2010. Cancer is becoming more and more common around the world. New cancers are constantly being discovered. Researchers are finding new ways to detect cancer and treat it so that the fatality rate does not rise. However, there are some cancers that researchers have not yet discovered a cure for. It is very important for Cancer Research to continue so that one day these cancers will no longer be a treat.
... the air of five different strains of lab grown breast cancer cells, also lab grown healthy human breast tissue. Scientist had blown air sample sober their flies while examining the insects under a microscope, to find out the different glow patterns. Not only did the antenna give off different patterns between cancer cells and the healthy ones, but also between the different types of breast cancer cells. According to “University of Konstanz” this is the first time scientist have proven that fruit flies are able to distinguish cancer cells. The studies and the knowledge of scientists can develop the next generation of cancer techniques. By scientist researches they hope a chemical detection will catch some cancer signs earlier in the beginning of the cancer stage. Scientist say that their research are still far from being accurate, and can’t yet be used on patients.
Bioengineering analysis is pointing a new way to better drug designs and better drug testing. The disease of cancer has taken the life of many patients, but through new medicines and procedures many more are surviving. A significant progress has been made against cancer, allowing people to live longer and fuller lives. There have been more than one-million less cancer deaths since 1990and 1991(aacr.org). On January 1, 2012 there were 13.7 million survivors in the United States. These numbers are achieved by using new techniques to cure cancer like, immunotherapies to avoid toxins, Targeted cancer therapies to target different types of cancer, and weakling cancerous tumors making them susceptible to drugs. Cancer is still a significant problem and is far from being cured, but step by step biomedical engineers are getting closer and closer.
Cancer is the uncontrolled growth of abnormal cells in the body. Tumors are then created and interfering with the digestive, nervous and circulatory systems. It is one of the most leading causes of death, reaching at about 8.2 million deaths in 2012. It is expected that cancer will rise from 14 million to 22 million within the next 2 decades. With over 100 cancer research centers in the United States studying how to treat this disease, people need to understand the importance of donating also with the awareness of signs and symptoms in the early stages. But, what are we doing about it? Do we have the technology to finally be able to put this deadly disease to an end?
Nanotechnology has found many potential applications in the area of functional foods by engineering biological molecules toward functions very different from those they have in nature, opening up a whole new area of research and development.
Nanotechnology includes nanorobots which are so small that they can be injected into the human bloodstream after which the nanorobots can do investigations or repair at cellular level. Nanorobots could optimize the delivery of pharmaceutical products, these means that medicines which are targeted on a specific type of cells can be delivered to only those cells by the nanorobots. The robots can attach to the cells after which they can inject the drug into the target cells. This could be a great breakthrough for cancer treatments such as chemotherapy because there is a minimal chance of injecting healthy cells with the drug and therefor negative side effects can be avoided.
Gingerols, which is the main active component in ginger and responsible for its distinctive taste can also help in inhibiting the growth of cancer cells. In a research made for colorectal cancer, mice were injected cancer cells and only 4 tumors are found in those treated with gingerol c...