Histopathology favours biopsies ‘fixed’ on glass slides for examination whereas molecular pathology concentrates its efforts at a molecular and genetic level to aid in diagnosis.
Sharing certain aspects of practice with other disciplines of pathology like clinical pathology, anatomic pathology, biochemistry, and molecular biology, molecular pathology seeks to understand and diagnose, at a molecular level, the mechanisms and origins of diseases (Harris and McCormick 2010). Through patient samples tests are carried out to measure the levels of macromolecules such as DNA, RNA and proteins to see how they differ from levels in an undiseased state (MRC 2014).When a diagnosis is built on morphologic changes in tissues using traditional anatomic pathology and molecular pathology together, a more accurate diagnosis is possible (Cai et al. 2014).
Because molecular pathology focuses on the development, evolution and progress of diseases at a molecular level it can be applied to patients as well as being used in biomedical research (Saikia et al. 2008).
To improve the prognosis for cancer patients an increased understanding of molecular and cell biology has to occur. Over the last few years there has been a notable increase in the knowledge of cancer molecular genetics and already a point has been reached where this can be transferred into clinical applications.
Many diseases are caused by genetic mutations inherited from one or both parents’ i.e. lysosomal storage diseases, muscular dystrophy, or cystic fibrosis. Other gene...
... middle of paper ...
...ny genetic alterations so would be absent from any molecular pathology tests. In histopathology these alterations can be seen and diagnosed as in the cases of inflammation, dysplasia and metaplasia.
There is still a place for conventional histopathology in pathology and there will continue to for a while yet. Histopathology is still the gold standard, but as with everything histopathology will need to change and adapt as new tests become cheaper, more reliable and available. Already the likes of PCR are common place in labs and molecular pathology will expant over the next decade. Next generation sequencing cannot be ignored due to its potential to redesign healthcare and give personalised medicine to everyone who needs it. Histopathologists will have to learn and adapt as these new applications are introduced (Hunt J. 2008; Wall and Tonellato. 2012))
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Career of a Medical Laboratory Technologist Choosing which career path to follow is one of the most important decision people take in their lifetime. Considering that this decision will affect the entire future life, it is very important to be sure that it is the right one. It is one of the most important steps in order to successfully find a job that would satisfy personality needs and guarantee a steady income. If he or she is passionate about their job, hard work is simplified and high salary helps to concentrate on results.... [tags: career choices]
1124 words (3.2 pages)
Naturally Occurring T Regulatory Cells, Interleukins 10 and 12 in the Pathogenesis of Idiopathic Warm Autoimmune Hemolytic Anemia.
- ABSTRACT There is now compelling evidence from animal models autoimmune hemolytic anemia (AIHA) that naturally occurring regulatory T cells (n-Tregs) play an important role in immunologic tolerance and control of immune-mediated pathology. However their study in human AIHA is still ill defined. Aim: To measure the peripheral blood proportions of n-Treg cells and the levels of IL10 and IL12 in basal and mitogen-induced (Lipopolysaccharide, LPS) cultures of PBMCs in patients with idiopathic warm AIHA (wAIHA) in a trial to ravel out some enigmatic aspects in the pathogenesis of this autoimmune disorder.... [tags: Medical Science]
3984 words (11.4 pages)
- New long-term painkiller: The scientists are working on a new painkiller, which will be very useful in daily life for everyone. It is a painkiller which will work for almost a week. It is discovered by the combination of saxitoxin with liposomes. Saxitoxin blocks sodium ion channels on the nerve cells and can prevent the transmission of action potentials. Liposomes are some particles that dissolve real slowly which helps the distribution of drug slowly so that its effect can last long. The news caught my eye because; if this painkiller comes in the market it will be revolutionary development in medical science.... [tags: Medical Science]
684 words (2 pages)
- Forensic Pathology as a Career The career that I researched was forensic pathology. The job of a pathologist is to determine a person’s cause of death by examining tissues and fluids from the body. A forensic pathologist does this as well, but they are trained to examine people who died unexpectedly or violently and to recognize other things that a regular pathologist might not, such as recognizing something as intentional rather than accidental. They have to determine who the person is, the time of death, the manner of death, and if it was accidental, the instruments which caused the death.... [tags: Forensic Pathology Careers Medical Essays]
672 words (1.9 pages)
- In addition, the cost of college today is on the rise. Expenses keep growing and growing; Stretching bank accounts and parents’ wallets, families look at the reality of debt from college costs. College expenditures include room and board, tuition and possibly a meal plan for the year or semester, and other miscellaneous supplies. Since the bulk of financial expenses at college come from tuition and fees, the article “Tuition and Fee’s” from scholarships.com, recommends staying within the state where one resides.... [tags: pre-medicine, medical school]
2014 words (5.8 pages)
- George Cheyne's concepts about medical science and the way the human body functions was in many ways very modern, but also still involved very conventional ideas that were well known techniques and concepts that had been accepted by the medical community. In The English Malady Cheyne began to make the transition from previous ideas in the medical community. 1.Cheyne had many ideas about the body that could be seen as the basis for modern medical views. a)Describing separate systems based on physical organs and systems instead of humors “These need only suppose, that the Human Body is a Machine of an infinite Number and Variety of different Channels and Pipes, filled with various and differen... [tags: Medical Science]
1030 words (2.9 pages)
- Imagine for one moment that you are living in the 1800’s and are in need of medical help. During this time surgeons were known for the treating of wounds, amputations, and treatment of broken bone. Picture yourself lying on a dirty cot, or soiled table waiting for the surgeon to come in. When he finally enters he is wearing a bloody, dirty apron and informs you that the only option is to remove your limb. He calls in for help in holding you down and picks up a stained saw and prepares to remove your leg.... [tags: Medical Science]
1070 words (3.1 pages)
- Nanotechnology, as described by Merriam-Webster Dictionary (2014) is, “ the science of manipulating materials on an atomic or molecular scale especially to build microscopic devices”. In recognizing the complexity associated with this definition, it is safe to say that many different achievements as well as controversies have come along with it. Although the category of nanotechnology is extremely broad the research attached to it is growing at a rapid pace as well . There are many unexplored areas that have caused researchers as well as the public to question what types of positive or negative affects it might have on our world as a whole.... [tags: microscopic devices, nanotechnology]
1565 words (4.5 pages)
- Reductionism is a method of explanation that assumes the workings of complex phenomena are reducible to the relationship of their simpler, fundamental, constituents. This practice is utilized in some form or another throughout nearly all fields of science: including physics, chemistry, ecology, sociology, medical sciences, etc. Reducing complex systems to the mechanisms of their parts is risky – it neglects properties that may emerge from the system as a whole. These emergent properties may be unpredictable, unnecessary, or unprecedented and, therefore, must be observed from higher levels of organization.... [tags: anti-reductionism, holism, medical treatment]
884 words (2.5 pages)
- In last decades Nano technology attentioned as an applied technology. This technology is producing and controlling materials, tools and new systems in molecular-atomic size that created from combination of physics, chemistry and biology sciences. The new Nano size materials have new benefits and characteristics that did not had before. Nano technology have different kinds of operations, like: alimentary, drugs, Medical diagnosis, bio technology, electronics and computers, communication, transportation, energy, safety, health and environment, aero spacing and etc.... [tags: nano technology, molecular-atomic]
1305 words (3.7 pages)