The exact mechanism of migraine headaches has not yet been elucidated. Gene studies, combined with the high correlation of family history with migraine susceptibility, give considerable evidence for a significant geneti...
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... concern with a fungus-based drug class called the ergotamine derivatives (e.g., dihydroergotamine), which also act as agonists at 5-HT receptors throughout the body and are much less specific than the triptans. Because of this potential for additive effects, administration of triptans and ergotamine derivatives should be separated by 24 hours. Lastly, overuse of acute migraine medications can lead to rebound headache symptoms known as “medication-overuse headache,” though the medications most commonly associated with this are opiates and analgesics, not triptans. Triptan-related medication-overuse headache is much more relegated to populations of men with high headache frequency. Nevertheless, it is still recommended for patients to restrict their intake of acute “rescue” migraine medication, including triptans, to 2 or 3 days per week to avoid rebound headache.
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