Mesenchymal stem cells originate from the mesoderm, the middle germ layer of an embryo, and play a vital role in the formation of connective tissue such as bone, cartilage, marrow, fat and blood. They are also precursor cells that help to produce cardiac, skeletal, and smooth muscle. Mesenchymal stem cells are found in every organ of the body but are most commonly obtained from bone marrow. Mesenchymal stem cells are classified as multi-potent stem cells. Multi-potent stem cells can transform into many different cell types that are of the same lineage. These innate traits make them prime candidates for use in developing heart disease treatments. While research and clinical trials are still in their infant stages, mesenchymal stem cells possess many desirable characteristics necessary to successfully regenerate heart tissue and restore heart function after heart attack.
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...the Treatment of Myocardial Infarction.” Heart, Lung and Circulation 18 (2009): 171-80. Web.
Meirelles, da Silva, Lindolfo, Aparecida Maria Fontes, Dimas Tadeu Covas, and Arnold I. Caplan. “Mechanisms involved in the therapeutic properties of mesenchymal stem cells.” Cytokine & Growth Factor Reviews 20 (2009): 419-27. Web.
Porada, Christopher D. and Graca Almeida-Porada. “Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery.” Advanced Drug Delivery Reviews 62 (2010): 1156-61. Web.
Shi, Rui-Zhen and Qing-Ping Li. “Improving outcome of transplanted mesenchymal stem cells for ischemic heart disease.” Biochemical and Biophysical Research Communications 376 (2008): 247-50. Web.
United States. Dept. of Health and Human Services. “National Vital Statistics Reports.” cdc.gov US Dept. of Health and Human Services, 20 May 2010. Web. 27 Mar. 2011.
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