Intestinal Vesicle of Nematodes

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S. carpocapsae and X. nematophila are mutualistic symbionts that parasitize, kill and use insects for reproduction. S. carpocapsae develop into non-feeding infective juveniles (IJ’s). The S. c. IJ’s serve as vectors for the X. n. The vector IJ’s then colonize at a place termed the vesicle. X. n. are released from the vesicle, via nematode defecation, into a new insect host. This process serves as a model to understand general aspects of horizontal transmission of symbionts by their hosts. It takes very few X. n. cells that are retained in the intestinal vesicle to initiate colonization of S. c.

Microbial attachment to host tissues plays an important role in the initiation of pathogenic and nonpathogenic microbe-host interactions. Besides providing a basis for hosts, specific interaction between bacterial and host molecules is important in determining the ability of some bacterial species to colonize certain hosts, but not others.

Fimbriae, nonfimbrial adhesins and polysaccharides are the general classes of bacterial outer surface structures that mediate adherence to host tissue receptors. Many of the biochemical activities for these processes still remain unknown.

A study of the morphology of the intestinal vesicle was done using differential interference contrast (DIC) light microscopy and transmission electron microscopy. The study concluded that the vesicle is a modification of the anterior nematode intestine and forms independently of bacterial colonization.

The nematode Steinernema carpocapsae and bacteria Xenorhabdus nematophila were studied in this paper. Their symbiotic relationship is formed when X. nematophila bacteria adhere to a site consisting of spherical bodies in the lumen of the nematode’s inte...

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The effects of this symbiotic relationship could be exploited in the real world. It provides a viable alternative to the use of insecticides. The discharged bacteria consume insects, eliminating their ability to impede the normal growth of crops. This method has been shown to be quite effective. Also it is favored over traditional chemicals as the use of nematodes and bacteria poses virtually no risk to consumers.

Applications to medicine:

Two important compounds have been isolated from Xenorhabdus: nematophin and xenorxide. Nematophin is an antifungal and antibacterial agent. Xenorxide has been shown to attack cancer cells, found in the lungs, breasts, prostate, and colon, and to leave healthy cells alone. The major advantage of these chemicals is that they may be used to combat strains of bacteria that have become resistance to conventional antibiotics.

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