Since 1985, MTX has been used as an effective drug in rheumatoid arthritis , psoriasis , acute lymphoblastic leukemia  lymphoma, head and neck cancer , breast cancer  and osteosarcoma . Additionally, MTX-conjugated AuNPs distinguished by cytotoxic effects on human choriocarcinoma cells  and MTX liposome were used as oral drug delivery carriers .
A LC-MS/MS based method was recently used to estimate MTX polyglutamate concentration in the red blood cell . Recent spectroscopic studies reveal the interaction of MTX with nucleic acids  or serum albumin .
Various spectroscopic methods have been used to study the interaction of small organic molecules with proteins. Several studies reveal the interaction of flavonoids , dyes , allosteric effectors  or other organic compounds  with hemoglobin.
Moreover, some studies focused on interaction of various antibiotics as oxytetracycline , chloramphenicol  and cephalosporines  with hemoglobin:
In particularly, hemoglobin interacts with several drugs: docetaxel , alprazolam-a sedative and antidepressant drug , tramo...
... middle of paper ...
...anda, and P. Karmakar, “Alprazolam induced conformational change in hemoglobin.,” Int. J. Biol. Macromol., vol. 41, no. 1, pp. 23–9, Jun. 2007.
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 J. R. Lakowicz, “Principles of Fluorescence Spectroscopy BT - Principles of Fluorescence Spectroscopy,” in Princ. Fluoresc. Spectrosc., Springer New York, 2006, p. 954.
 G. M. Artmann, L. Burns, J. M. Canaves, A. Temiz-Artmann, G. W. Schmid-Schönbein, S. Chien, and C. Maggakis-Kelemen, “Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature.,” Eur. Biophys. J. EBJ, vol. 33, no. 6, pp. 490–496, 2004.
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