In the modern world humans have been able to design and create nearly anything, most to aid us in our daily lives and improve our standard of living. It is only inevitable that eventually humans would take our superior knowledge and skill to manipulate life itself and change our genome to produce a healthier and even more superior human standard of life. In recent years discussion about gene therapy has changed into a promising possibility to treat many of our common human diseases and disorders. Although gene therapy might be the answer to many problems, it has been met with a number of logistical and ethical hardships. With the prospect of being a treatment for inherited genetic disorders, cancers, and viral infections, gene therapy seems like the logical fix-it-all bandage that many people would benefit from. Gene therapy is a relatively new concept owing mainly to our current knowledge of the human body and the relatively modern understanding of genetic coding and process. We now are able to better identify and understand the genetic causes of human ailments, and are just beginning to understand how to fix, replace, or eradicate the chromosomal basis for these issues; this is the concept of gene therapy. However logistically dealing with the small structure of genes, chromosomes, and DNA is not as easy as repairing a cracked wall or damaged water pipe, we are dealing with complex and microscopic materials that ordinary tools cannot deal with. Manufacturing such tools to deliver corrective DNA into affected cells within the body is just one of the obstacles that scientists and researchers are facing. Arthur Bank, guest journalist for BioJournals, recently detailed that modifying viruses proves to be an effective w... ... middle of paper ... ... therapy. With further research and development it might just be possible to take the genetic evolution of the human genome into our own hands. However, it is no surprise that there are some that question the ethical background of such a procedure. Works Cited "An Introduction in Gene Therapy." Haemophilia 6.(2000): 110-114. Academic Search Premier. EBSCO. Web. 16 July 2011. Bank, Arthur. "Human Somatic Cell Gene Therapy." BioEssays 18.12 (1996): 999. Academic Search Premier. EBSCO. Web. 16 July 2011. Southwell, Amber L., and Paul H. Patterson. "Gene Therapy in Mouse Models of Huntington Disease." Neuroscientist 17.2 (2011): 153-162. Academic Search Premier. EBSCO. Web. 16 July 2011. "Genetics Home Reference: Gene Therapy." Genetics Home Reference. U.S. National Library of Medicine, 11 JUL 2011. Web. 16 Jul 2011. .
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
Sade R.M.,and G. Khushf “ Gene therapy: ethical and social issues.” J So Carolina Med
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
Gene therapy is a relatively simple process. First, the mutated gene at fault for the cause of the condition being treated must be identified. Second, the site of the unhealthy cells in the human has to be found. Then, a health...
Panno, J. (2005). Gene therapy: Treating disease by repairing genes. New York, NY: Facts on File, Inc.
Gene therapy is a method used by doctors that ‘uses genes as medicine’. It repairs faulty or damaged gene copies by transferring a therapeutic or working gene into specific parts of faulty gene copy. This means that gene therapy can be used to replace a faulty gene or to introduce a new gene whose function is to modify the clinical course of a condition or to cure a problem in the gene (Refer to image 2). Image 1 shows how gene therapy is completed using an adenovirus vector while image 2 explains the method of gene therapy and shows how cells are removed, altered and injected back into the patient. Gene therapy has potential to treat and cure many medical conditions such as various types of cancer, degenerative diseases and viral infections such as AIDS. Research into gene therapy still needs to be done before this approach to the treatment of certain conditions will realise its full potential. Trials are being conducted in the United States and Europe and a modest number initiated in other countries, including Australia. The majority of these trials are focussing on treating acquired conditions such as cancer (European Society of Gene & Cell therapy, 2011).
Gene therapy has become an exciting and controversial issue on the scientific and medical horizon. Science offers new technologies that, in the future, will be able to treat and cure common genetically passed diseases. However, as it is an extremely broad subject, some time must be dedicated to its interpretation and explanation. First, a general definition of gene therapy is required. Genethics, the Clash between the New Genetics and Human Values, by David T. Suzuki and Peter Knudtson, defines gene therapy as "the medical replacement or repair of defective or faulty genes in living human cells." It is not really so elementary as the definition would imply. Within gene therapy there lie certain aspects, some more controversial than others, some more achievable and probable than others. The ethical question must be addressed at each turn. However, all of this will be discussed at greater length subsequently.
This article gives an insight on the current trends on gene therapy because it offers critical analysis of gene therapy both at the beginning to the current state. It also explores the position of patients who underwent gene therapy so as to ascertain whether this therapy has been successful or not. This helps in establishing the reason why this mode of therapy has been gaining slower acceptance than it initially
Gene therapies necessity, stems from the fact that it can cure, life threatening gene based diseases, with minimal after effects. Although there are some ethical and physical issues that can occur through this technology, when comparing it to the other genetic technologies, it’s quite reliable. Although it is in its infancy, the technology has still been present for several years, with the first case of gene therapy being done in 1990. Sure, there have been some complications, but its still a growing technology with a strong future in front of
Image what it would be like if doctors could cure Huntington's disease, muscular dystrophy, or even hemophilia. Could this be possible? With gene therapy this all could be reality in the near future. Gene therapy is a potential approach to the treatment of genetic disorders in humans. This is a technique where the absent or faulty gene is replaced by a working gene, so the body can make the correct enzyme or protein and consequently eliminate the root cause of the disease (BIO, 1990).
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
There are many people in this world with disorders and diseases that disrupt the balance of crucial proteins in the human body necessary for proper function and survival. Without these important proteins such as enzymes, humans are bound for disability and/or death. Recently, Gene Therapy has been more researched and studied, and is currently being improved and developed for the benefit of mankind. However, with the rise of this new and effective type of therapy, there comes a heavy topic of debate over the ethical issues in bringing this revolutionary research into play. Certain questions arise on the subject of this treatment such as: How can “good” and “bad” uses of gene therapy be distinguished? Who decides which traits are normal and which
Gene therapy poses many risks, but may prove the ideal solution for countless diseases. As seen throughout the past few decades, gene therapy can cure genetically inherited diseases by introducing therapeutic genes into the body. Critics may argue that there are moral and ethical problems associated with this novel technique, but for the most part scientists realize the importance this advancement will have. Gene therapy may be the key to curing dozens of diseases, and has endless possibilities, but more research is needed before its safe or accepted as common practice.