111Indium is the radionuclide of choice for imaging neuroendocrine tumors because of its half-life of 2.8 days with gamma energies of 173 and 247 keV. Tagging 111Indium to pentetreotide, a tagged peptide (also known as octreotide), the radionuclide binds to somatostatin receptors found on the surface body cells. Somatostatin is a growth inhibiting neuropeptide hormone produced in the hypothalamus and stored and released from the anterior pituitary, which allows the secretion of gastrin, insulin, glucagon, calcitonin, growth hormone, and serotonin (Mallinckrodt Medical, Inc. 1994). Somatostatin receptor sites include the anterior pituitary, lymphocytes, pancreatic islet cells, as well as tumors that may be located within the brain, breast, and lung. Less than 10% of patients have noted abdominal issues, feeling of queasiness, or pain at the place of inoculation. Before receiving the dose of 111In-pentetreotide, patients with pancreatic insulinoma should receive an intravenous injection of glucose to ensure t...
... middle of paper ...
...eline for somatostatin receptor scintigraphy with 111In-pentetreotide. Journal of Nuclear Medicine, 42 (7), 1134-1138.
Cryer, P. Shlomo, M., Polonsky, K. S., Larsen, P. R., Kronenberg, H. M. (2011). Williams Textbook of Endocrinology. Philadelphia, PA: Elsevier Saunders.
Hanson, M.W. (2001). Scintigraphic evaluation of neuroendocrine tumors. Applied Radiology, 30 (6), 11-17.
Krenning E.P., De Jong, M, Kooij, P.M., et al. (1999). Radiolabelled somatostatin analogue for peptide receptor scintigraphy and radionuclide therapy. Annals of Oncology, 10 (2), 23-29.
Mallinckrodt Medical, Inc. (1994). Somatostatin receptor imaging for neuroendocrine Tumors: Product Monograph/OctreoScan.
Yarbro J.W., Bornstein, R.S., Mastrangelo, M.J. (1994). Somatostatin receptor imaging: Tumor localization, detection, and therapeutic implications. Seminars in Oncology, 21 (13), 1-71.
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