Approximately, 1 of every 500 people is affected with hypertrophic cardiomyopathy, it is important for patients to understand the dynamics of the disease as it could potentially be life threatening. In most cases, the patients quality of life is not affected, but a few will experience symptoms that cause significant discomfort or undetected complications that could lead to sudden cardiac death. With that in mind, it would be beneficial to recognize what it is, specific causes, the steps of diagnoses, and the options for treatment.
What is it?
Hypertrophic cardiomyopathy is an inherited disease that affects the cardiac muscle of the heart, causing the walls of the heart to thicken and become stiff. [1] On a cellular level, the sarcomere increase in size. As a result, the cardiac muscles become abnormally thick, making it difficult for the cells to contract and the heart to pump. A genetic mutation causes the myocytes to form chaotic intersecting bundles. A pathognomonic abnormality called myocardial fiber disarray. [2,12] How the hypertrophy is distributed throughout the heart is varied. Though, in most cases, the left ventricle is always affected. [3] The heart muscle can thicken in four different patterns. The most common being asymmetrical septal hypertrophy without obstruction. Here the intraventricular septum becomes thick, but the mitral valve is not affected. Asymmetrical septal hypertrophy with obstruction causes the mitral valve to touch the septal wall during contraction. (Left ventricle outflow tract obstruction.) The obstruction of the mitral valve allows for blood to slowly flow from the left ventricle back into the left atrium (Mitral regurgitation). Symmetrical hypertrophy is the thickening of the entire left ven...
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...edical Association
[9] "Hypertrophic Cardiomyopathy." American Heart Association. ©2014 American Heart Association, Inc., n.d. Web. 27 Mar. 2014.
[11] Nishimura, Rick A., Ommen, Steve R., Tajik, A.J., (2003) Hypertrophic Cardiomyopathy: A Patient Perspective. Dallas, TX: American Heart Association,
[12] Ho, Carolyn Y, MD; López, Begoña, PhD; Coelho-Filho, Otavio R, MD; Lakdawala, Neal K, MD; Cirino, Allison L, MS, CGC; Jarolim, Petr, MD, PhD; Kwong, Raymond, MD; González, Arantxa, PhD; Colan, Steven D, MD; Seidman, JG, PhD; Díez, Javier, MD, PhD; Seidman, Christine E, MD. (2010) Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy, Boston, MA: Massachusetts Medical Society
[13] "Hypertrophic Cardiomyopathy." The Cleveland Clinic Foundation for Continuing Education. © 2000-2014 The Cleveland Clinic Foundation, Jan. 2009. Web. 27 Mar. 2014.
Cardiogenic shock can acute or chronic disorders that effect the function of the heart in supplying adequate tissue/organ perfusion.
The aim of this report is to provide an overview of chronic heart failure, examining signs symptoms and treatment related to the case study, and the anatomy and physiology of the heart will be discussed, and the pathophysiology of chronic heart failure.
Hypertrophic Cardiomyopathy, also known as HCM, is a type of heart disease that affects the Cardiac Muscles and Cardiac Muscle cells. This disease occurs if the Cardiac Muscle cells enlarge, which causes the wall of the heart’s ventricles (most often the left ventricle) to thicken. It can also cause stiffness in the ventricles, as well as mitral valve and cellular changes.
“Hypoplastic left heart syndrome accounts for 9% of all critically ill newborns with congenital cardiac disease, causing the largest number of cardiac deaths in the first year of life.(2) ” HLHS is a severe heart defect that is present at birth. HLHS combines different defects that result in an underdeveloped left side of the heart. This syndrome is one of the most challenging and difficult to manage of all of the congenital heart defects. Multiple portions on the left side of the heart are affected including the left ventricle, the mitral and aortic valve, and the ascending aorta. These structures are greatly reduced in size, or completely nonexistent causing the functionality of the left heart to be reduced, or non-functional all together.
The thickening of the muscle cells do not necessarily have to change the size of the ventricles, but can narrow the blood vessels inside the heart. Hypertrophic cardiomyopathy can be grouped into two categories: obstructive HCM and non-obstructive HCM. With obstructive HCM, the septum (the wall that divides the left and right sides of the heart) becomes thickened and blocks the blood flow out of the left ventricle. Overall, HCM usually starts in the left ventricle. HCM can also cause blood to leak backward through the mitral valve causing even more problems. The walls of the ventricles can also become stiff since it cannot hold a normal amount of blood. This stiffening causes the ventricle to not relax and entirely fill with
Hypertrophic cardiomyopathy is a genetic disease of the heart, making the cardiac muscle is thick and strong. The thick muscle causes a decrease in cavity size, forcing the heart to pump less blood. Hypertrophic cardiomyopathy is one of the primary causes of sudden death as the prevention of blood flow causes cardiac arrest. More successful research is being conducted on HCM, including research on the genetics associated and the heredity of the genes. Unfortunately this disorder effects many young athletes due to their increased stresses of training on their heart. However, despite the use of new technology such as the electrocardiogram and transthoracic echocardiogram, the strategies are limited, restricting new answers.
Capture Myopathy? Not very often a diagnosis is termed liked this, especially in the field of human medicine, especially n the field of cardiology the where the term myopathy is revered as Cardiomyopathy. Myopathy is a disease that affects the muscles and causes weakness due to dysfunction of muscle fibers (1); Cardiomyopathy is of the same circumstance but deals primarily with the heart. Capture Myopathy is relative to many animals, especially mammals and provides a definitive correlation to humans and their potential medical prognosis of Cardiomyopathy. Capture Myopathy is a syndrome that that occurs within captive animals and causes rapid death through excessive adrenaline within the bloodstreams. (3) Capture Myopathy is quite often referred to as white muscle disease, the muscle when used causes a change of metabolism from using oxygen to using the stored energy within the muscle. The change up allows for lactic acid to build up and make its way into the bloodstream where it changes the homeostasis of the body: the body pH and the heart output. In essence, if the heart is inefficiently pumping the correct oxygen to the muscle, the muscle will begin to deteriorate and ultimately lead to damages to the kidney and the effector organs. (2) Animal Capture Myopathy is very relatable to human Takotsubo Cardiomyopathy, and thus this paper will aim to trace how animals are very relatable to humans even through the Cardiovascular System based on normal physiology and stress. (WHAT SHOULD I TALK ABOUT?)
Patients with dilated cardiomyopathy will often have normal thickness of the ventricles with an enlarged right, left, or both ventricular cavities. In the early stages of this disease, there is an initial increase in the stroke volume from the increased force of contraction due to the stretching of the myocardium, which is described by the Frank-Starling mechanism. However, as the disease progresses, the heart loses that compensatory mechanism leading to a decrease in the strength of the contraction of the heart, hence, a decrease in left ventricular ejection fraction. There are two types of DCM, primary and secondary. Primary dilated cardiomyopathy are usually idiopathic in nature, however, “approximately 30% of cases” have a “familial transmission pattern.”3(138) Secondary dilated cardiomyopathy, on the other hand, are associated with “alcohol abuse, cocaine abuse, the peripartum state, pheochromocytoma, infectious diseases (human immunodeficiency virus infection), uncontrolled tachycardia, Duchenne’s muscul...
The article Following The Trail of Broken Hearts by David Epstein from Sports Illustrated, was about Hypertrophic Cardiomyopathy and the affects it has on adolescents and teens, especially student athletes. DeCarlo Polk, one of the 6,000 people who die from HCM a year, died while playing a one-on-one game of basketball due to strain on his heart. Hearts of people with HCM have thickened left ventricles, causing the heart to beat a lethal cadence. Increasing the knowledge of Hypertrophic Cardiomyopathy could save thousands of lives per year.
Left-sided heart failure is the most common type of heart failure, and it is a result of left-ventricular dysfunction. This disease poses a significant threat to patients because the primary function of the left side of the heart is to provide sufficient oxygenated blood to satisfy the metabolic demands of the body’s cells. Understanding the main function of this portion of the heart will help with the understanding of other complications associated with this diseased. Left-sided heart failure is usually the result of the loss of heart muscle function, specifically in the left ventricle secondary to coronary artery disease, prolonged hypertension, or myocardial infection (Lewis et al. 2014, 766). The pathophysiology of left-sided heart failure is primary a macroscopic disorder and will be described as such.
It is essential to the human body that the heart pump sufficient nutrient rich blood to the body’s cells, because the body won’t be able to function normally otherwise. When a heart muscle is unable to pump enough blood through to meet the body’s regular demand it is characterized as heart failure. Heart failure can usually be treated through conventional heart therapies and symptom management strategies, however conventional therapies don’t work for all patients with heart failure, this is what is depicted as advanced heart failure or end-stage heart failure. In other words “End stage” heart failure is when the condition becomes so severe that all conventional treatments no longer work, the only treatment that works for end stage heart failure is to have a heart transplantation-surgery to remove a person's diseased heart and replace it with a healthy heart from a deceased donor. However there are two large encompassing problems with this treatment. The first problem is that the patient is subject to shortages in donor organ availability and thus possible further decompensation and potential death while awaiting transplantation. According to the American Heart Association, there are over 500,000 new cases of end-stage heart failure in the United States every year. With only 2200 donor hearts available every year nearly 20-30% of the patients who die while they await a transplant. The second problem with this mode of treatment is that not all patients qualify for heart transplantation. Patients who have another disease in addition to end-stage heart failure do not qualify for heart transplantation. The discrepancy between the clinical need for donor hearts and the total number of hearts available, as well as the lack of treatment o...
“Heart failure is a chronic, progressive condition in which the heart muscle is unable to pump enough blood through to meet the body's needs for blood and oxygen” (American Heart Association, 2012, para 3). What this basically means is that the body is functioning in a way that the heart cannot keep up with. Although heart failure can be acute and occur suddenly, it usually develops over time and is a long-term or chronic condition. There are two different types of heart failure, left-sided and right-sided, and they can be caused by other diseases such as diabetes, coronary heart disease, or high blood pressure (National Institutes of Health, 2012). In most cases, both sides of the heart are affected simultaneously.
Familial hypertrophic cardiomyopathy (feline HCM) in Maine Coons is a very serious myocardial disorder that often leads to sudden death due to heart failure. The Maine Coon (American Longhair) is the largest and oldest natural breed of domestic cat in North America with a distinct appearance with a lion-like ruff and a tail that resembles a raccoon’s and is good at hunting. HCM is when “a primary structural disorder of the myocardium; characterized by left ventricular hypertrophy… no symptoms to sustained palpitations, heart failure and sudden cardiac death” (2013). This is caused by a mutation of P.A31P in the cMyBP-C (myosin binding protein C) gene and these being the first non-human cases “feline familial HCM provides a valuable model
There are three main types of disease that cause cardiomegaly. The main type is dilated cardiomyopathy. This is when the walls of both the right and left ventricles become thin and stretched. Hypertrophy cardiomyopathy is when the hearts left ventricle becomes abnormally thick as a result of high blood pressure and hypertrophic cardiomyopathy is a result of an inherited condition.
(Slide 2) What is Cardiomyopathy? If we break down the word we can see “Cardio” which means of the heart, “myo” which means muscle, and “pathy” which means disease, therefore cardiomyopathies are diseases of the heart muscle. (Slide 3) There are 3 main types of cardiomyopathies; hypertrophic, dilated, and restrictive. I will only be discussing dilated cardiomyopathy, which is characterized by the enlargement of the hearts chambers with impaired systolic function. It is estimated that as many as 1 of 500 adults may have this condition. Dilated cardiomyopathy is more common in blacks than in whites and in males than in females. It is the most common form of cardiomyopathy in children and it can occur at any age (CDC).