The Human Ebolavirus ( Ebov ) Epidemic Essay

The Human Ebolavirus ( Ebov ) Epidemic Essay

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The Human Ebolavirus (EBOV) epidemic has been widely publicized in the last few years due to outbreaks in West Africa and even the United States of America. The Human EBOV is one of the deadliest viruses on the planet. According to the Centers for Disease Control (CDC), the Human EBOV is categorized as a Class A agent of bioterrorism and a Biosafety Level 4 pathogen, with no specific treatment available.1 The only type of treatment addresses treating the symptoms of the Human EBOV, which is a half-measure compared to targeting the actual virus. According to the World Health Organization, the Human EBOV typically has a mortality rate around 50%, but past outbreaks of the virus have been anywhere from 20-90%, depending on the specific strain of Human EBOV.6 The first known outbreaks of the Human EBOV occurred in Central Africa (what is now South Sudan, and the Democratic Republic of Congo)6 in small villages near the tropical rainforests. The virus first infects wild animals, most commonly thought to be monkeys, which can then be transmitted to humans through a variety of ways, which then spreads through the human population through transmission.6 While some people may have certain biological differences that may protect them against the Human EBOV, generally the Human EBOV is not preventable or susceptible to treatment at this time. Research is being conducted to find therapies that would successfully combat the Human EBOV. Current understanding of the cell entry of Human EBOV is very limited, and therefore so is the ability to create effective therapies or anti-viral medication. Even with all the uncertainty, past research has led to known facts about the mode of cell entry and the cell cycle of Human EBOV, along with a few bioche...

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... a variety of ways, by first infiltrating a cell, and then it hijacks the cell to replicate itself while at the same time, disrupting the immune system for protection. However, once it is detected, the Human EBOV attacks the white blood cells, macrophages and monocytes to spread the virus throughout the host body. The virus also attacks the hepatocytes in order to keep the body signaling that antibodies are needed at that location. This allows for the Human EBOV to continually infect new cells to further infect the host body. The therapies that exist today are therapies for other diseases or pathogens that target specific non-mutable sites of the host. Currently there are not any therapies that target the Human EBOV specifically, since we are still learning new information about the mechanisms present in the infection, translation, and replication of the Human EBOV.

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