Bio 5 Wednesday #76
May 8, 2014
“Efficacy Results of a Trial of a Herpes Simplex Vaccine”
Herpes is a widely known virus that infects the body and causing warts usually in the genital or oral regions of the body. Herpes is caused by one of the two types of virus, Herpes simplex virus type 1 (HSV-1), or herpes simplex virus type 2 (HSV-2). There is no cure for the Herpes Simplex virus. Once the host is infected, the virus remains in the body for the entire lifespan. The virus can be suppressed with help of medication to help keep the virus dormant and reduce outbreaks of genital warts or cold sores around the mouth. Symptoms of the Herpes Simplex virus may vary but typically include, for oral, pain, tingling or itching of the lips as well as cold sores. For genital herpes the symptoms include pain, tingling or itching on or around the genitalia, the buttocks, or the inner thighs. Genital herpes also includes blisters on or around the penis/vagina or anus, which then break and form scab. It may also include a burning sensation while urinating.
The Herpes Simplex 1 virus is spread through saliva including mouth to genitalia. Herpes simplex 2 is spread through genital contact even with the anus. Though there is no known cure for the Herpes Simplex virus, one or two, there have been attempts to create a vaccine to help prevent further spread of the virus. The New England Journal of Medicine recently conducted an experiment to test Two vaccine and test their efficacy.
The Experiment was conducted in 2012 with 12,468 women the ages of 18-30. These women were recruited from 40 sites in the U.S and 10 from Canada. Each woman was tested to make sure they were seronegative for the Herpes Simplex virus 1 and 2. I...
... middle of paper ...
...hen those of the controlled group.
Subjects reported adverse events such as redness, pain, and swelling at the injection site. Subjects also reported feeling malaise, fatigue, headaches, and fevers. These symptoms seemed to be more prevalent in the HSV-vaccine subjects than those of the controlled group during the first dose. Symptoms decreased after doses two and three.
The tally for subjects who acquired the disease changed due to the type of vaccine each subject was given. If we look at the graph we can closely see the relation between each vaccine and which did better in fighting off the disease.
This graph plots the data of two groups of individuals that were injected with either the HSV-vaccine or the Hepatitis A vaccine, also known as the controlled group. As we can see from the graph the subjets injected with the HSV-vaccine were at a much higer risk
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