Introduction
Hepatitis B virus (HBV) infection is reported as a major health problem in Africa, Western Pacific and Asian countries especially in sub-Saharan Africa with population 65 million patients that has chronic HBV [3, 4]. The HBV infection is interplay between virus replication and host immune system. Large numbers of regulatory T cell (Treg) are found in the HBV patients because the HBV specific CD8 T cell is inhibited by this Treg cell [5]. By transmitting through the skin or mucous membrane, HBV will cause chronic infection and affect the liver cancer and followed with hepatocellular carcinoma (HCC) [2]. Basically, HBV infection are described by four levels of phase that is immune tolerant phase, immune reactive phase, resolution phase and reactivation phase [2].
Hepatitis B and Hepatocellular Carcinoma
Hepatocellular carcinoma is one of the diseases that closely related to the infections with hepatitis B virus (HBV). The institution of Taiwan’s program of universal Hepatitis B vaccination reported that children have stronger association towards HBV and hepatocellular carcinoma compared to adult. After 10 years of launching the vaccination program, the data reported that the incidence of hepatocellular carcinoma is declined from 0.52 to 0.13 referring to the children between 6 to 9 years [1]. In addition, early detection of hepatocellular carcinoma can be enhancing by screening the HBV with ultrasonography and alfa-fatoprotein [2]. The decrease in HBsAg-seropositivity automatically reduced the rate of horizontal HBV infection and reflects the decline in hepatocellular carcinoma [1].
Based on the case-control and cohort studies show that the presence of HBsAg in serum causes the chronic HBV infection and elevated for...
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...atient with moderate HBV and offered 4-6 months interferon, 1 year course of lamivudine and adefovir. However, the patient that has chronic HBV is not recommended to use the treatment because the efficacy of existing therapy is very low but at the same time, it must be monitored [4]. In patients, interferon-α are contraindicated with the severe depression, autoimmune disease or deteriorated HBV related cirrhosis. Other than that, interferon-α also give the better response to the HBV genotype A and B compared to the genotype C and D [6, 10].
After 1 year treatment with interferon-α, the HBeAg of HBV patients are lost about 15-25% [4]. Lamivudine on the other hands show that 10-15% with lower incidence seroconversion of HBeAg [4, 10]. Emergence of adefovir resistance is associated with liver failure and reported that resistance to adefovir is slower that lamivudine.
The Hepatitis B virus is a disease that affects the liver and results in swelling and loss of normal function in the liver. It is estimated that 350 million people are infected with Hepatitis B worldwide, with 50 million new cases diagnosed every year.(1) In the Unit...
Clinical Infectious Diseases, 49(3), 438-443. Doi:10.1086/600391. See full address and map. Medicare.gov/Hospital Compare - The Official U.S. Government Site for Medicare (n.d).
Hepatitis B Virus (HBV) is a virus that leads to infection of the liver. Infection of the HBV can be acute or lifelong (chronic). Humans are the only known host for HBV (CSC, 2017). This virus can survive on environmental surfaces for up to seven days (WHO, 2017).
Hepatitis B Virus (HBV) is a virus that attacks the liver. The virus is transmitted through blood and bodily fluids. This can occur through direct blood-to-blood contact, unprotected sex, use of contaminated needles, and from an effected mother to her newborn during the delivery process. The majority of people do not have noticeable symptoms when they are first infected with the HBV. People who do not know they are infected with the HBV, their body can respond in different ways. I learned that some of the common symptoms of Hepatitis B infection include fever, fatigue, muscle or joint pain, loss of appetite, mild nausea, vomiting, and dark-colored urine. Some of the serious symptoms that require immediate medical attention and maybe even hospitalization are: severe nausea and vomiting, yellow eyes and skin (jaundice), bloated or swollen stomach.
HAV is known to be an infectious disease that usually occurs in children and young adults .The disease is usually transmitted from person to person through contaminated food, liquids or oral fecal route. An example would be when someone is carrying the virus and doesn’t wash their hands after using the restroom and then puts food in their mouth. HAV is most common in developing countries because of the living conditions and inadequate water, poor sewage facilities and sanitary conditions. The highest HAV levels in the world are from India,” Earlier reports suggest that India is hyperendemic for HAV infection2,4-6 with very high infection rates,” (Sowmyanarayanan). Most HAV are without severe complications, “Virus HAV infection rarely causes fulminant hepatic failure in people…,” (Vento,p.1) . The symptoms for HAV are high fever, nausea, vomiting and jaundice...
Hepatitis B is a bacterial infection that displays symptoms like a visible rash on the surface of the skin, headache, abdominal pain, fatigue, anorexia, chills, severe liver damage, and can even lead to death. It can be contracted through close contact, especially sexual contact, through lesions on the skin from an infected person (Leu). Another required vaccination is Tdap. “It usually enters the body through the mouth and begins its replication in the throat and gastrointestinal tract. It moves to the bloodstream and continues to replicate and destroy motor neurons in the central nervous system. These are the motor neurons responsible for control of the muscles for swallowing, circulation, respiration and movement of the trunk, arms and legs” (Furnari). The last required vaccination is Hib. Symptoms for Hib include asthma, upper respiratory tract infections, lung disease, recurrent bronchitis, and death. Each of these vaccinations are required by schools to ensure the health of their
Hepatitis B is a DNA viral infection that causes damage and inflammation to the liver. It was first discovered in 1965 by Dr. Baruch Blumberg. The HBV virus is very contagious and is even thought to be the most serious form of viral hepatitis and the most common viral infection on Earth. “HBV is 100 times more infectious than HIV.” (Green, 2002, pg. 7) The virus can survive for about one week outside the body on a dry surface. According to Green (2002, pg. 7), “One in twenty Americans has been infected with the virus at some point in their lives.” Between the ages of 15-39 is when 75% of new HBV infections occur, according to Green (2002, pg.8).
The signs and symptoms of blood borne pathogens vary based on the type of disease it is and the ability of a person’s immune system to fight it off. In most cases hepatitis B does not need to be treated and the body can fight it off on its own. However a long-term infection can develop in some people that can cause liver damage. There is a vaccination available to prevent acquiring the disease. The signs and symptoms for hepatitis C are usually mild. It can take two weeks to six months after contact before signs begin to show, or there may not be any symptoms at all. Hepatitis C typically becomes is a long-term infection and after many years will cause liver ...
Acute HBV infection is the most common type of infection in low endemic countries. The incubation period, from transmission to clearness, ranges from 40-180 days. The infection is either symptomatic or asymptomatic/ fulminant hepatitis. Children under the age of 5 years rarely experience symptomatic infection (10%), where’s about 30-40% infected adults and children above age 5 experience a symptomatic infection with yellowing of skin and teeth, vomiting, fatigue, laxity and abdominal pain [1].
There are a number of ways that the current treatment for hepatitis C could improved. In the future researchers aim to develop a more effective, safe and well-tolerated interferon therapy. They have also created a new vaccine technology that has been tested in mice for its therapeutic efficiency against the most conserved regions of the hepatitis genome. They hope to eventually develop drugs that target the hepatitis C RNA-dependant RNA polymerase enzyme, which is responsible for the replication of the entire hepatitis C genome, and prevent the replication of the hepatitis C virus directly.9 Although hepatitis C is a very serious disease of the liver, technologies and medications have been proven to be effective in many chronically infected persons with hepatitis C virus.
There is a disease spreading out in the world called Hepatitis C. It affects the liver and may cause the liver to fail. This disease is caused by a virus called Hepatitis C virus which is also known as HCV. About 32,000 people are affected with this disease per year only in the United States area. Some It’s a disease with many symptoms and many causes. of these symptoms are easy bruising, upset stomach and fever. These are just some of the many symptoms that come from the virus. Hepatitis Cs nature of the causative agent is determined by many things. The biological data of this disease is filled so much information. It is estimated that over 180 million people have gotten Hepatitis C and it is growing.
HBV infection is complex and affects a large population worldwide. The discovery of the Australia antigen (HBsAg) in 1965 by Blumberg et al. (1965) set the stage for rapid progress in understanding and counteracting the disease (qtd in Zuckerman et al. 210). Liver function tests help in estimating the extent of damage caused to the liver during HBV infection. Diagnosis is done by detecting viral specific antigens in the serum. Both active and passive immunization options exist for disease prophylaxis. However, it is always best to practice caution over the parenteral, sexual and other routes of transmission of the disease for effective disease prevention and prophylaxis.
Hepatitis A virus, until 1 week after onset of illness or as directed by the health department when passive immunoprophylaxis (currently, immune serum globulin) has been administered to appropriate children and staff and a licensed physician states in writing the child may
Alpha interferons are used to treat several diseases, including some types of cancer, such as hairy cell leukemia, melanoma, follicular non-Hodgkin's lymphoma, and AIDS-related Kaposi's sarcoma.
Hepatocellular carcinoma (HCC) may begin as a single tumor that grows larger over time or as a group of small tumors on and inside the liver that multiply and grow. HCC is most common in people with cirrhosis (chronic liver damage) or Hepatitis, and it is the most common form of liver cancer in adults. This type of liver cancer accounts for 4 out of 5 primary liver cancer diagnosis.