Hemolytic Uremic Syndrome Initiated By Escherichia Coli Essay

Hemolytic Uremic Syndrome Initiated By Escherichia Coli Essay

Length: 1457 words (4.2 double-spaced pages)

Rating: Strong Essays

Open Document

Essay Preview

Hemolytic Uremic Syndrome Initiated by Escherichia coli
Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria. There are two types of Shiga toxins that can lead to HUS, Shiga Toxin 1 (Stx1) and Shiga Toxin 2 (Stx2). There have been structural differences found between the two types as well as evidence to show that type 2 Stx causes more detrimental kidney damage then Stx1 (Bauwens, A., et al., 2011). HUS initiated by E. coli is a detrimental systemic disease that can be prevented by taking precautions with safe food handling and proper hand washing.
Pathophysiology
Hemolytic Uremic Syndrome often starts with a hemorrhagic bout of diarrhea due to the Shiga-like toxins that are present in E. coli and generally takes between two and 14 days from exposure to develop. Shiga toxins got their name from Shigella dysenteriae which is dysentery causing bacteria that was first discovered by Kiyoshi Shiga in 1898 (Basu, D. & Tumer, N., 2015). Shiga toxins are ribosome inactivating proteins that cause injury to the microvascular endothelial cells contained within the kidneys, brain and other organs (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011). Shiga toxins are AB5 toxins which bind cellular ligand glycosphingolipid globtriaosylcermide (Gb3) (Bauwe...


... middle of paper ...


...s. This highly destructive renal function disease can be prevented by simple things such as food safety precautions and proper hand washing. Food needs to be cooked and stored at certain temperatures to inhibit the growth and transmission of E. coli. Proper hand washing is something that should be done much more frequently then it is, especially after using the restroom and handling food that may or may not be contaminated. It is unfortunate that often times individuals overlook food safety and hand washing and cause other individuals to contract E. coli that can lead to HUS. In addition to education about sanitary issues there should be more research into the use of antibiotics to treat the initial onset of E. coli, in certain cases the use of strong antibiotics can actually increase the amount of Stx2 toxin that being produced which can lead to the onset of HUS.


Need Writing Help?

Get feedback on grammar, clarity, concision and logic instantly.

Check your paper »

Hemolytic Uremic Syndrome ( Hus ) Essay

- Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011)....   [tags: Renal failure, Nephrology, Kidney, Shiga toxin]

Strong Essays
1543 words (4.4 pages)

Hemolytic Uremic Syndrome ( Hus ) Essay

- Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome (HUS) is a rare condition that affects renal functioning and can become life threatening. HUS is characterized by microangiopathic hemolytic anemia, thrombocytopenia and impaired renal function (IJKD, 2013). HUS will often onset after an infection of Escherichia coli which is a Shiga toxin producing bacteria. Certain medications (Quinine, some chemotherapy drugs, and anti-platelet medications), infections (HIV/AIDS, pneumococcal bacteria), genetics, and even pregnancy can also induce the onset of Hemolytic Uremic Syndrome (Mayo Clinic, 2013)....   [tags: Renal failure, Nephrology, Kidney, Shiga toxin]

Strong Essays
1170 words (3.3 pages)

Escherichia Coli ( E. Coli Essay

- Escherichia coli (E. coli) is a member of the Enterobacteriaceae family of organisms. It is a non-spore forming, facultative anaerobic, gram negative rod capable of growing on a variety of media and, similar to other members of the Enterobacteriaceae family, contains the enterobacterial common antigen. Most E. coli are part of the normal flora of the human gastrointestinal tract, however some strains are pathogenic and capable of causing clinical disease. Epidemiologic classification of E. coli is based on the expression of certain surface antigens....   [tags: Escherichia coli, Bacteria]

Strong Essays
1293 words (3.7 pages)

E. Coli : Bacteria Essay

- E. Coli Infection E. coli are bacteria that can cause an infection in various parts of your body, including your intestines. E. coli bacteria normally live in the intestines of people and animals. Most types of E. coli do not cause infections, but some produce a poison (toxin) that can cause diarrhea. Depending on the toxin, this can cause mild or severe diarrhea. This condition can spread from one person to another (contagious). Toxin-producing E. coli can also spread from animals to humans. Most cases of E....   [tags: Escherichia coli, Bacteria, Milk, Dehydration]

Strong Essays
718 words (2.1 pages)

Escherichia Coli Is A Member Of The Family Enterobacteriaceae Essay

- Escherichia coli is a member of the family Enterobacteriaceae. It is a bacterium with a cell wall that has many components. Escherichia coli can live without oxygen which means that it is a facultative anaerobe. It is also capable of fermenting lactose under anaerobic conditions, and in the absence of alternative electron acceptors. There are effects and various factors that limit its growth rate. Its morphology consists of a rod-shaped gram negative bacteria that is commonly found in soil, water, vegetation, human intestines, as well as the intestines of animals....   [tags: Escherichia coli, Bacteria, Cell, Diarrhea]

Strong Essays
909 words (2.6 pages)

Essay on Escherichia Coli : Coli And Coli

- ABSTRACT: Water samples from local ponds and lakes and snow runoff were collected and tested for coliform as well as Escherichia coli. Humans as well as animals come into contact with these areas, some are used for recreational activities such as swimming and some are a source of drinking water for both animals and humans The main goal of this experiment was to see which lakes, snow run off and ponds tested positive for coliform or Escherichia coli and to come up with some reasoning as to why. It was found that the more remote pond with less contact contained the most Escherichia coli....   [tags: Escherichia coli, Bacteria, Water pollution, Lake]

Strong Essays
1024 words (2.9 pages)

Essay on Escherichia Coli : A Model Bacterium For Genetic Transformation

- In this experiment, the most studied bacterium, Escherichia Coli, is utilized as a model bacterium for genetic transformation. E. Coli is a model bacterium since it can extensively be studied to understand a specific phenomenon. The benefits of E. Coli refer back to the observation that it can survive varied conditions; is a single-celled bacterium; is able to rapidly reproduce and grow; most E Coli strains are harmless; E Coli can easily be genetically transformed. Diving more in depth in this experiment, genetic transformation can occur through projectile bombardment, electroporation or heat shock....   [tags: Bacteria, Plasmid, Escherichia coli, Genetics]

Strong Essays
1595 words (4.6 pages)

The Efficient Against Escherichia Coli Essay

- TESTING ANTIMICROBIALS TO FIND OUT MOST EFFICIENT AGAINST ESCHERICHIA COLI Ana Shafer 1. INTRODUCTION Fighting against germs and microbes that may harm us is a never ending battle. Humans have so many ways to disinfect our bodies, our mouths and even our surroundings. Finding an antimicrobial that will rid us and the world around us of microbes that will harm us is nearly impossible. It is a common fact that there is nothing in this world that will kill 100% of germs. Escherichia coli is bacteria that lives in human and animal’s intestines....   [tags: Bacteria, Escherichia coli, Antiseptic]

Strong Essays
1051 words (3 pages)

Coli : H7 And Enterotoxigenic E.coli Essay

- GENERAL INFORMATION Escherichia coli, or more commonly known from its abbreviated form E.coli, are a type of bacteria found in the environment, food, water, and in the intestines of humans and other animals such as cattle and pig (Ferens, W. & Hovde, C. (2011). Most strains or types of E.coli are relatively safe, but there are certain strains that can be dangerous and cause sicknesses such as E.coli O157:H7 and Enterotoxigenic E.coli (ETEC). E.coli O157:H7 can cause bloody diarrhea, kidney failure, and even death through release and production of the Shiga Toxin....   [tags: Escherichia coli, Bacteria]

Strong Essays
747 words (2.1 pages)

Essay about Esherichia Coli

- Micro 2924, section 310 July 21, 2010 Escherichia Coli Introduction: Esherichia coli also known as E. coli is a bacterium that lives in your gut. (1). it was founded by Theodore von Esherich in 1888. There are many people that can get the bacteria. Also there are thousands of strands of E.coli. Six E. coli O157 outbreaks were identified during 2007. Four of the outbreaks involved foodborne transmission. (Eshericha Coli). Six Minnesota cases and one Wisconsin case with the same or closely-related PFGE subtype of E....   [tags: Microbilogy]

Strong Essays
720 words (2.1 pages)