Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria. There are two types of Shiga toxins that can lead to HUS, Shiga Toxin 1 (Stx1) and Shiga Toxin 2 (Stx2). There have been structural differences found between the two types as well as evidence to show that type 2 Stx causes more detrimental kidney damage then Stx1 (Bauwens, A., et al., 2011). HUS initiated by E. coli is a detrimental systemic disease that can be prevented by taking precautions with safe food handling and proper hand washing.
Hemolytic Uremic Syndrome often starts with a hemorrhagic bout of diarrhea due to the Shiga-like toxins that are present in E. coli and generally takes between two and 14 days from exposure to develop. Shiga toxins got their name from Shigella dysenteriae which is dysentery causing bacteria that was first discovered by Kiyoshi Shiga in 1898 (Basu, D. & Tumer, N., 2015). Shiga toxins are ribosome inactivating proteins that cause injury to the microvascular endothelial cells contained within the kidneys, brain and other organs (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011). Shiga toxins are AB5 toxins which bind cellular ligand glycosphingolipid globtriaosylcermide (Gb3) (Bauwe...
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...s. This highly destructive renal function disease can be prevented by simple things such as food safety precautions and proper hand washing. Food needs to be cooked and stored at certain temperatures to inhibit the growth and transmission of E. coli. Proper hand washing is something that should be done much more frequently then it is, especially after using the restroom and handling food that may or may not be contaminated. It is unfortunate that often times individuals overlook food safety and hand washing and cause other individuals to contract E. coli that can lead to HUS. In addition to education about sanitary issues there should be more research into the use of antibiotics to treat the initial onset of E. coli, in certain cases the use of strong antibiotics can actually increase the amount of Stx2 toxin that being produced which can lead to the onset of HUS.
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- Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011).... [tags: Renal failure, Nephrology, Kidney, Shiga toxin]
1543 words (4.4 pages)
- Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome (HUS) is a rare condition that affects renal functioning and can become life threatening. HUS is characterized by microangiopathic hemolytic anemia, thrombocytopenia and impaired renal function (IJKD, 2013). HUS will often onset after an infection of Escherichia coli which is a Shiga toxin producing bacteria. Certain medications (Quinine, some chemotherapy drugs, and anti-platelet medications), infections (HIV/AIDS, pneumococcal bacteria), genetics, and even pregnancy can also induce the onset of Hemolytic Uremic Syndrome (Mayo Clinic, 2013).... [tags: Renal failure, Nephrology, Kidney, Shiga toxin]
1170 words (3.3 pages)
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