Hemolytic Uremic Syndrome (HUS) is a rare condition that affects renal functioning and can become life threatening. HUS is characterized by microangiopathic hemolytic anemia, thrombocytopenia and impaired renal function (IJKD, 2013). HUS will often onset after an infection of Escherichia coli which is a Shiga toxin producing bacteria. Certain medications (Quinine, some chemotherapy drugs, and anti-platelet medications), infections (HIV/AIDS, pneumococcal bacteria), genetics, and even pregnancy can also induce the onset of Hemolytic Uremic Syndrome (Mayo Clinic, 2013). HUS is in essence a clinical diagnosis that is supported by abnormalities in lab values (AJCP, 2004). HUS is the most common cause of renal failure in children under the age of 5. Immunocompromised adults as well as healthy adults can also experience HUS (Mayo, 2013).
Hemolytic Uremic Syndrome often starts with a hemorrhagic bout of diarrhea due to the Shiga-like toxins that are present in E. coli and normally takes between two and 14 days from exposure to develop. Shiga toxins got their name from Shigella dysenteriae which is a dysentery causing bacteria that was first discovered by Kiyoshi Shiga in 1898 (Basu, D. & Tumer, N., 2015). Shiga toxins are ribosome inactivating proteins and cause injury to microvascular endothelial cells within the kidneys, brain and other organs (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011). Shiga toxins are AB5 toxins which bind cellular ligand glycosphingolipid globtriaosylcermide (Gb3) (Bauwens, A., 2011). The Shiga toxins modify the large rRNA and inhibit protein synthesis (Basu, D., et al., 2015). The toxins remove adenine from the rRNA as wel...
... middle of paper ...
...a complete recovery but there can be residual effects. Some have irreversible kidney damage and need to have transplants and some have to remain on blood pressure medications to prevent further kidney damage (Mayo, 2013).
Hemolytic Uremic Syndrome (HUS) is a rare condition that affects renal functioning and can become life threatening. This highly destructive disease can be prevented by simple things such as food safety precautions and hand washing. Food needs to cooked and stored at certain temperatures to inhibit the growth and transmission of E. coli. Hand washing is something that should be done much more frequently then it is, especially after using the restroom and handling food that may or may not be contaminated. It is unfortunate that often times individuals overlook food safety and hand washing and cause other individuals to have to go thru HUS.
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria (Bauwens, A., Bielaszewska, M., Kemper, B., Langehanenberg, P., von Bally, G., et al., 2011).... [tags: Renal failure, Nephrology, Kidney, Shiga toxin]
1543 words (4.4 pages)
- Hemolytic Uremic Syndrome Initiated by Escherichia coli Hemolytic Uremic Syndrome (HUS) is a rare systemic condition that affects renal functioning and can develop into a life threatening disease with lasting complications. HUS is characterized by microangiopathic hemolytic anemia (destruction of red blood cells due to damage of small blood vessels), thrombocytopenia (an abnormal drop in platelet count) and impaired renal function (Nayer, A. & Asif, A., 2013). HUS can often onset after an infection of Escherichia coli which is a Shiga toxin-producing bacteria.... [tags: Renal failure, Nephrology, Kidney, Shiga toxin]
1457 words (4.2 pages)
- Contents Introduction History Characteristics Mechanism of action Factors affects growth Toxins Symptoms Transmission Complications Outbreaks Food Association Diagnosis Disinfetants Trearment Vaccination Preventions References Enterohemorrhagic Escherichia coli Introduction E.coli is a gram negative bacteria present in the form of rods(bacillus) in the Enterobacteriaceae. Mostly E.coli are normal commensals of intestines so that isolation of pathogenic strains on the basis of Virulence factors e.g toxins.... [tags: bacteria, contamination,treatment]
1501 words (4.3 pages)
- In class we was given the task of identifying unknown broth cultures, I received number 69. I went through several tests to figure out what bacterium I received. First I created a slide of the broth by putting a small amount of the broth on the slide and letting it dry for ten minutes. Next I stained the slide by applying the reagents; crystal violet, grams iodine, decolorizer and safranin. From that I discovered that this bacterium was gram-negative, this would determine the next couple of tests I would do to identify my unknown bacterium.... [tags: Escherichia coli, Bacteria]
1094 words (3.1 pages)
- Escherichia coli (E. coli) is a member of the Enterobacteriaceae family of organisms. It is a non-spore forming, facultative anaerobic, gram negative rod capable of growing on a variety of media and, similar to other members of the Enterobacteriaceae family, contains the enterobacterial common antigen. Most E. coli are part of the normal flora of the human gastrointestinal tract, however some strains are pathogenic and capable of causing clinical disease. Epidemiologic classification of E. coli is based on the expression of certain surface antigens.... [tags: Escherichia coli, Bacteria]
1293 words (3.7 pages)
- E. Coli Infection E. coli are bacteria that can cause an infection in various parts of your body, including your intestines. E. coli bacteria normally live in the intestines of people and animals. Most types of E. coli do not cause infections, but some produce a poison (toxin) that can cause diarrhea. Depending on the toxin, this can cause mild or severe diarrhea. This condition can spread from one person to another (contagious). Toxin-producing E. coli can also spread from animals to humans. Most cases of E.... [tags: Escherichia coli, Bacteria, Milk, Dehydration]
718 words (2.1 pages)
- Escherichia coli is a member of the family Enterobacteriaceae. It is a bacterium with a cell wall that has many components. Escherichia coli can live without oxygen which means that it is a facultative anaerobe. It is also capable of fermenting lactose under anaerobic conditions, and in the absence of alternative electron acceptors. There are effects and various factors that limit its growth rate. Its morphology consists of a rod-shaped gram negative bacteria that is commonly found in soil, water, vegetation, human intestines, as well as the intestines of animals.... [tags: Escherichia coli, Bacteria, Cell, Diarrhea]
909 words (2.6 pages)
- Foodborne illness results from eating food contaminated with bacteria (or their toxins) or other pathogens such as parasites or viruses. The illnesses range from upset stomach to more serious symptoms, including diarrhea, fever, vomiting, abdominal cramps, and dehydration. Although most foodborne infections are undiagnosed and unreported, the Centers for Disease Control and Prevention estimates that every year about 76 million people in the United States become ill from pathogens in food. Of these, about 5,000 die.... [tags: contaminated food]
1756 words (5 pages)
- The Center for Disease control has estimated that illnesses directly resulting from food contamination cause approximately 76 million illnesses, 325,000 hospitalizations, and 5,000 deaths each year in the United States. The rise of food-related illnesses can be mostly attributed to increased eating out. Half of every dollar spent on food in this country is spend on food prepared outside of the home. As the amount of people involved preparing our food rises, so does the risk of contracting an illness from food (Levitt).... [tags: essays research papers fc]
1100 words (3.1 pages)
- Shigella flexneri Shigella flexneri, a facultative anaerobe belonging to the family Enterobacteriaceae, is a Gram-negative rod that is the causative agent of diarrhea and dysentery in humans. Potentially life-threatening, S. flexneri's effects include bacteremia, hemolytic uremic syndrome (HUS) and toxic megacolon (4). The principle disease of diarrhea and dysentery caused by this pathogen is known as shigellosis. 10-100 organisms are sufficient to cause disease, and transmission is generally from person-to-person by way of fecal-oral (2).... [tags: Medical Health Biology Essays]
965 words (2.8 pages)