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Important of gene therapy to humans essay
Gene therapy pros and cons
Importance of gene therapy essay
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Introduction The usage of genes as medicine give rise to the concept of 'Gene Therapy'. In the process of Gene therapy, a defective gene copy is repaired by transmitting therapeutic gene copy into those cells of an individual. So thereby, a faulty gene could be replaced or a medical condition may be corrected by introducing a new gene. Gene therapy has a promising future as it is powerful enough to treat many genetic conditions and also other deathly disease like AIDS, cancer etc. Though the potential of "gene therapy" is realized and recognized, it remains still on an experimental level and needs to worked on before accepting as the best solution. Gene therapy was put into practical use for treating immune deficiency disease called "adenosine deaminase" ADA deficiency in 1990s. This is when the gene transmittal of "corrective genes" into stem cells happened for the first time in practice. Method The task of making gene therapy to work yielding positive results is substantial. In order to put it to practical use, firstly we must understand well the defect in question and locate the faulty genes in the system. In addition to that, the identified defectives genes should be accessible, the appropriate healthy gene set or curative gene set should be made available and lastly a way to transmit this gene to that defective area must be clearly constructed. The final part is the most challenging procedure in the process of gene therapy. "Gene Delivery" denotes how to make the curative gene reach the defective area. Few of these vectors would assist us in the problem of 'gene delivery'. a) Harmless viruses A favorable method for "gene transfer" would be using harmless viruses as carriers of genes into cells. This method is not... ... middle of paper ... ...s, designed personalities, master races, or Frankenstein monsters will be created can be given no credence in the light of what is presently known. The best insurance against possible abuse is well-informed public. With proper safeguards offered by the scientific society, this powerful therapeutic procedure would provide great benefits reducing the sufferings and death caused by genetic disorders Works Cited [1] Aiuti A, Cattaneo F, Galimberti S et al. (2009) Gene therapy for immunodeficiency due to adenosine deaminase deficiency. New England [2] Journal of Medicine 360:447-458. [3] The Gene Therapy Research Unit, The Children’s Hospital, Westmead, Australia [online]. [4] Available from: http://www.chw.edu.au/prof/services/genetherapy/ [Accessed Feb 2014]. [5] http://www.extremetech.com/ [Accessed Mar 2014]. [6] http://ghr.nlm.nih.gov/handbook/therapy/ethics
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
There have been four somewhat recent successful gene therapy treatments. The four deal with correcting hemophilia, bone marrow transplants, skin cancer, and vessel growth. In the success with the bone marrow transplants, French researchers collected bone marrow cells from patients, used gene therapy to correct the bone marrow, and then returned the bone marrow to the patient. This was 80% successful as reports 16 months after the transplants showed. Squamous cell carcinoma, skin cancer of the head and neck, was treated using gene therapy as well. The fourth trial was where DNA was used to carry a substance that stimulates blood vessel growth to damaged heart tissue and in this trial there was much success noted.
In recent years, great advancement has been made in medicine and technology. Advanced technologies in reproduction have allowed doctors and parents the ability to screen for genetic disorders (Suter, 2007). Through preimplantation genetic diagnosis, prospective parents undergoing in vitro fertilization (IVF) can now have their embryo tested for genetic defects and reduce the chance of the child being born with a genetic disorder (Suter, 2007). This type of technology can open the door and possibility to enhance desirable traits and characteristics in their child. Parents can possibly choose the sex, hair color and eyes or stature. This possibility of selecting desirable traits opens a new world of possible designer babies (Mahoney,
It was in the 1980’s that scientist began looking at alternative ways of treatments, one is gene therapy. Scientist would insert human genes into a bacteria cell. Then the bacteria cell would transcribe and translate the information into a protein. Once that is done the scientist would then introduce the protein into human cells. Gene therapy can be simply viewed as inserting bits of foreign DNA into a patient’s tissue in hope...
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Gene therapy is a technique which has developed in the wake of recombinant DNA (rDNA) technology. It is a process which results in the correction of a genetic disorder by the addition of a piece or fragment of DNA into the genetic material of a living, functioning cell. A mere thirty years ago this concept belonged to the realm of the human imagination made manifest in the works of science fiction. Today it belongs to the realm of the human imagination made manifest in the works of science, period. It is mind boggling to try to comprehend the far reaching effects of gene therapy. How is it affecting society? Who will benefit from its use? Should it be used at all? Should research continue? How do we answer all of these questions? The answers are not readily available, nor are they black and white, but an attempt at finding some solutions must be made. Before exploring this line of thought further, a basic understanding of the technical aspects of gene therapy is essential.
To conclude, although gene therapy can cure a wide variety of diseases which cannot be cured by traditional medicine, and patients can get permanent cure without rejections, it can be high-risk and immoral. The negative effects of gene therapy lead to the shrink of the number of volunteers, and many trials have been forced to cease. The Gene therapy's potential to revolutionize medicine in the future is exciting, and hopes are high for its role in curing and preventing childhood diseases.
It was a treatment for a four-year-old girl named Ashanthi DeSilva, who were born with an adenosine deaminase (ADA) deficiency, an autosomal recessive disorder that affect the immune system. Her doctors genetically modified her defective immune cells to function as normal ones. Then, they used a virus that also had been genetically modified to remove its harmful genes to deliver the corrected immune cells back to her body. This early success led to many other gene therapy trials in the 1990s for different kinds of genetic diseases, until a tragic setback happened. In September 1999, Jesse Gelsinger became the first person who died after undergone a gene therapy for ornithine transcarbamylase (OTC) deficiency, a rare metabolic disorder. He died from massive organ failure caused by a bad reaction of his immune system to the virus used in the therapy (Thompson
People should not have access to genetically altering their children because of people’s views on God and their faith, the ethics involving humans, and the possible dangers in tampering with human genes. Although it is many parent’s dream to have the perfect child, or to create a child just the way they want, parents need to realize the reality in genetic engineering. Sometimes a dream should stay a figment of one’s imagination, so reality can go in without the chance of harming an innocent child’s life.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Genetic engineering has also opened the doors for humans to choose the different various traits they wish their offspring to feature by unnaturally selecting them. The unnatural selection of humans may have begun as a result of a new type of discrimination due to genetic screening (Cummins 4).
Human Genetic Engineering: Designing the Future As the rate of advancements in technology and science continue to grow, ideas that were once viewed as science fiction are now becoming reality. As we collectively advance as a society, ethical dilemmas arise pertaining to scientific advancement, specifically concerning the controversial topic of genetic engineering in humans.
Human genetic engineering can provide humanity with the capability to construct “designer babies” as well as cure multiple hereditary diseases. This can be accomplished by changing a human’s genotype to produce a desired phenotype. The outcome could cure both birth defects and hereditary diseases such as cancer and AIDS. Human genetic engineering can also allow mankind to permanently remove a mutated gene through embryo screening, as well as allow parents to choose the desired traits for their children. Negative outcomes of this technology may include the transmission of harmful diseases and the production of genetic mutations.
Gene therapy enables patients to survive incurable diseases. In the field of genetic diseases, ADA-SCID, CGD and hemophilia are three main ones. ADA-SCID is known as the bubble boy disease. CGD is related to immune system that would lead to fungal infections which are fatal. Patients with Hemophilia are not able to induce bold bleeding (Gene therapy for diseases, 2011). Gene therapy also has good effects on cancer treatment and neurodegenerative diseases, which include Parkinson’s disease and Huntington’s disease. Viral infections, including influenza, HIV and hepatitis can also be treats by it (Gene therapy for diseases, 2011). According to the Science Daily in 2011, gene therapy now can apply to heart failures and neurologic diseases as well.
Scientists and the general population favor genetic engineering because of the effects it has for the future generation; the advanced technology has helped our society to freely perform any improvements. Genetic engineering is currently an effective yet dangerous way to make this statement tangible. Though it may sound easy and harmless to change one’s genetic code, the conflicts do not only involve the scientific possibilities but also the human morals and ethics. When the scientists first used mice to practice this experiment, they “improved learning and memory” but showed an “increased sensitivity to pain.” The experiment has proven that while the result are favorable, there is a low percentage of success rate. Therefore, scientists have concluded that the resources they currently own will not allow an approval from the society to continually code new genes. While coding a new set of genes for people may be a benefitting idea, some people oppose this idea.