Gastroesophageal Reflux Disease Essay

Gastroesophageal Reflux Disease Essay

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Introduction
About 40 years ago the inappropriate level of gastric acid was a very major problem.That time very few medical treatments were available for this type of Gastroesophageal reflux disease(GRED).For this type of disease Heartburn was the most common type of symptom and the peptic ulcer was one of the most common type of disease. If it was untreated then it can be life threatening. That time the only cure of the disease to administration of antacid drugs. But it had only temporary effect. With the progress of the drug chemistry new drugs came into the market for the gastric diseases which effect is for the long time.These tpe of drugs are generally targeting the different type of receptor like Histamine(H2) receptor,proton pump receptors etc. In this review they showed the development of the new antacid drug by the structure activity relationship such as Omeprazole and Esoprazole.

Development History

The breakthrough of the GRED type diseases was in the late 1970 when antisecretory drug cimetidine was developed which is the antagonist of the Histamine(H2) which has the important role in the gastric juice secretion. After that cimetidine type compounds with the same type of mechanism of action has the good potential for the GRED but the effect is temporary. But it reduces the need of surgery. In this time one of the pharmaceutical company Astra, they are trying to develope some compound which inhibits the proton pump in the acid secretion the pariental cells of the stomach which is most important in the acid secretion step. After the long screening of the molecules they ended up with the drug called Omeprazole which was first launched as Losec in Europe in 1988 and in 1990 as Prilosec in US. This type of drug i...


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...who have the gastric tumour they use high dose of proton pump inhibitor drugs.
References:
1. www.wikipedia.org
2. Lindberg, P. et al. Omeprazole, the first proton pump inhibitor. Med. Res. Rev. 10, 15 (1990)
3. Saccomani, G., Crago, S., Mihas, A., Dailey, D. W. & Sachs, G. Tissue and cell localization of hog gastric plasma membrane by antibody techniques. Acta Physiol. Scand. (Suppl) 293–305 (1978)
4. Lindberg, P., Brandstrom, A. & Wallmark, B. Structure–activity relationships of omeprazole analogues and their mechanism of action. Trends Pharmacol. Sci. 8, 399–402 (1987)
5. Andersson, T., Rohss, K., Bredberg, E. & Hassan–Alin, M. Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole. Aliment. Pharmacol. Ther. 15, 1563–1569 (2001)
6. An Introduction to Medicinal Chemistry(4th Edition) By Graham L Patrick, Oxford University Press

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Gastroesophageal Reflux Disease Essay

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