High glomerular filtration is crucial for the normal renal function. Vasoconstriction and vasodilation of afferent and efferent arterioles are able to increase or decrease blood flow through glomerulus. As blood flows through the glomerulus, the glomerular capillaries filter the protein-free plasma. This contributes to an average net glomerular filtration rate (GFR) of approximately 125 mL/min (Sherwood, 2015, pp.496). Most...
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...bjects have an increase in GFR, which means having an increase in creatinine clearance, because of vasoconstriction, while there was no change in GFR in alkalosis subject. Because of excreting out more dilute urine, it is expected that hypotonic subject have a decrease in specific gravity. Alkalosis and control subjects should have an increase in specific gravity because the subject’s urine should become more concentrated overtime but less in volume. It is expected there will have no change in pH for isotonic and hypotonic subjects but an increase in pH for alkalosis subject because only alkalosis subject consumed bicarbonate solution which caused the urine to be more basic. It is hypothesized that sodium clearance of isotonic subject will increase and that of hypotonic and alkalosis subjects will decrease because of the decrease in osmolarity and activation of ANP.
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