Poliomyelitis (shortened to polio) has been around for thousands of years, and there is still no cure, but at the peak of its devastation in the United
States, Dr. Jonas Salk introduced a way to prevent it. Polio attacks the nerve cells and sometimes the central nervous system, causing muscle wasting, paralysis, and even death. The disease, whose symptoms are flu like, stuck mostly children, and in the first half of the 20th century the epidemics of polio were becoming more devastating. Salk, while working at the Virus Research
Lab at the University of Pittsburgh, developed a polio vaccine, and the medical trials to prove its effectiveness and safety are still being analyzed.
Fifty years ago the largest medical experiment in history took place to test Salk’s poliomyelitis vaccine. Close to two million children across the
United States and Canada were involved in the trial, which was administered by the National Foundation for Infantile Paralysis (NFIP), also known as the
March of Dimes. The foundation, created in 1938 by President Franklin D.
Roosevelt (a polio victim) and his law partner Basil O’Connor. Across the
United States, 623,972 school children were injected with the vaccine or a placebo, using a double blind technique in which neither recipient nor administrator knew which one there were getting. The results, announced in
1955, showed good statistical evidence that Jonas Salk’s “killed virus” preparation was 80-90% effective in preventing paralytic poliomyelitis.
The statistical design used in the experiment was singular, prompting criticism. Eighty four test areas in eleven states used a textbook model: in a randomized, blinded design all participating children in the first three grades of school (ages 6-9) received injections of either vaccine for placebo and were observed. At the same time though, 127 test areas in 33 states used an
“observed control” design: where the participating children in the second grade received injections of vaccine, no placebo was given, and children in all three grades were then observed for the duration of the polio season. The use of the dual protocol illustrates both the power and the limitations of randomized clinical trials. The control trials with the placebo were important to define the vaccine as the product of scientific medicine, while the observed trials were done to maintain public support for the vaccine.
In 1953, Salk presented his tests of a polio vaccine to the Immunization
Committee, the scientific advisory committee for the NFIP. The test results seemed promising to Basil O’Connor, as the children had shown no ill effects and the levels of polio antibodies in their blood had risen. However, several of the senior virologist on the committee questioned the relation of antibodies
Andrew Suy Professor Owens History 1302 13 April 2016 Polio: An American Story Polio, formerly known as poliomyelitis, an infectious viral disease that affects the central nervous system and can cause temporary or permanent paralysis. A debilitating disease that was once the affliction of our very own republic. David Oshinsky’s Polio: An American Story chronicles polio’s progression in the United States, a feat it does quite well throughout the course of the novel.
The Polio Journals: Lessons from My Mother, by Anne K. Gross, is the heartbreaking and emotional version of one woman’s life as a polio survivor. Carol Greenfeld Rosenstiel, the author’s mother, contracted polio in 1927 at the young age of two. From then until her death from lung cancer in 1985, Carol Rosenstiel was a paraplegic, suffering paralysis below the waist. She did successfully marry, raise children, and enjoy a profession as a concert musician while confined to a wheelchair. She kept journals that Anne Gross used, after her mother’s death, to reminisce her mother’s life. She was encouraged by her courageous and pitiless efforts to attain recognition in the world of the non-disabled.
This lead to the demise of the population when the disease was transported through the heart of an infected man. Once the doctors completed the heart transplant, the man came to life with the generic grey blood and he was much more hostile.... ... middle of paper ... ...
One of the other notable important advances was the “Conquest of Polio” this disease usually caused paralysis in the people who contracted the virus. Back then there...
Mosquitoes carried the diseases and when a person got bit he would give a disease to the mosquito and the mosquito would pass it on to the next victim ("Historical Overview").
The rail market continued to grow and by the 1860’s all major cities within the United States were connected by rail. The main diseases that showed the most virulence during the time were cholera, yellow fever and consumption, now known as tuberculosis. The 9th census mortality data showed that 1 out 7 deaths from disease were caused by tuberculosis and 1 out of 24 disease deaths were resulting from cholera. . Until the 1870s the general consensus of the spread of disease through population was still the primitive idea that it came from the individual and not specifically the pathogen.... ... middle of paper ... ...
Polio is a viral disease. It cripples thousands of people and infects even more every year. Even though millions are inoculated, and the polio disease has been successfully purged from hundreds of countries still thousands of people and developing countries are infected and still people are dying. According to the World Health Organization (WHO) polio affects the Central Nervous System, or CNS; by infesting the intestines and transmitting it into the nerves thought the blood vessels. There the virus spreads through the nerve cells to the brain stem or other motor units, while forever damaging the nerves.
North American children are now the most vaccinated on earth. Children receive about thirty-three doses of ten vaccinations by the age of five years. Not only do children need a separate vaccine for most diseases (hepatitis B, polio, Hib, and chicken pox are single vaccines; DTaP and MMR are multiple) but they generally need more than one dose of each vaccine. Because of the many vaccines needed, vaccination is an extremely controversial topic in the United States Today. Whatever side of the aisle you may fall with regard to your opinion about vaccination, one thing is for certain: the choice to vaccinate or not is a decision that has the potential to greatly impact the health of you and most importantly, your children for the rest of their lives.
...influenza pandemic in one way or another; the use of quarantines were extremely prevalent among them. Also, the pandemic is directly responsible for the creation of many health organizations across the globe. The organizations help track and research illnesses across the globe. The CDC (Centers for Disease Control and Prevention) for example, strive to prevent epidemics and pandemics. They also provide a governing body with directives to follow in case an outbreak does occur, and if one shall occur the efforts of organizations across the globe will be crucial for its containment. It is amazing that with modern medicine and proper organization that influenza still manages to make its appearance across the globe annually.
The first discovery was made in 1952, in the developing field of virology. Virology is the study of viruses and how they behave. To develop the vaccines for the viruses, researchers infected the HeLa cells with many types of infections, such as measles, mumps, and the infamous poliomyelitis virus, also known as Polio. According to the Centers for Disease Control and Prevention (CDC), whose mission is to save lives and protect people’s health security, Polio is a "crippling and potentially deadly infectious disease caused by a virus that spreads from person to person invading the brain and spinal cord and causing paralysis" (Freeman). Jonas Salk, who was a virologist at the National Foundation for Infantile Paralysis (NFIP), used inactivated viruses (virus particles grown in culture and then killed by a form of heat) to create a polio vaccine. Salk drew blood from about two million children, which the NFIP checked for immunization.Through the collection of many HeLa cells and trial and error, the polio vaccine wa...
Polio: An American Story describes a struggle to find a vaccine on polio through several researchers’ lives, and over the course of many years. The second thesis is the struggle between Salk and Sabin, two bitter rivals who had their own vaccine that they believed would cure polio. The author David M. Oshinsky, is describing how difficult it was to find the cure to a horrifying disease, which lasted from the Great Depression until the 1960’s. Oshinsky then writes about how foundations formed as fundraisers, to support polio research. Lastly, the author demonstrates how researchers were forced to back track on multiple occasions, to learn more about polio.
The death rate from Measles, Chicken Pox and Pertussis was much higher prior to 1930,
Vaccines are a big part of the modern world. They help our immune system in the same way someone runs a training course; preparing for something they may encounter in the future. Vaccines have many benefits that can help in the long run, that is why I stand in firm affirmation that vaccines should be required for children.
(Jane C Finlay, Noni E MacDonald, 2001). Working with Vaccine -hesitant parents. Canadian Paediatric Society. Retrieved May 3, 2013, from http://www.cps.ca
We are always hearing on the news and in newspapers about children catching diseases and often dying from them. Why is this happening when all of these diseases are easily preventable by simply being immunised, why aren’t parents getting their children Immunised, is it for religious beliefs or just carelessness. What ever their reason may be is it really good enough, because why would anyone rather let their child be able to catch and spread a deadly disease then have them Immunised, so Immunisation should be made compulsory for all children.