For many years, citizens of well-developed countries believed tuberculosis (TB) was an illness of the past. Tuberculosis is an infectious disease that can be caused by various strains of mycobacterium, primarily Mycobacterium tuberculosis (MTB). Mycobacterium tuberculosis has a waxy coating on its cell surface that makes it highly resistant to Gram staining, and consequently must be identified using Acid-fast techniques. Despite its resistance to Gram staining, Mycobacterium tuberculosis is classified as an acid-fast Gram-positive bacteria due to its lack of an outer cell membrane. Along with its resistance to stains, the cell wall has many characteristics that currently make it the center of many new studies. As some researchers struggle to understand the exact reasons for the re-emergence of tuberculosis, others are seeking new mechanisms and ways to inhibit the disease. (1) Mycobacterium tuberculosis, first discovered by Robert Koch in 1882 is an aerobic bacillus. Mycobacterium tuberculosis is naturally a pathogen of the mammalian respiratory system due to its need for an oxygen rich environment. Cell division occurs at an unusually slow pace in this species. Cell division can take anywhere from 15 to 20 hours, which is extremely sluggish in comparison to other bacteria. This bacterium requires very little water activity and can survive in a dry state for long periods of time. The lipid rich cell wall of Mycobacterium tuberculosis is responsible for the organism’s ability to withstand disinfectants and ability to act in a virulent manner. Alveolar macrophages in the lungs take up Mycobacterium tuberculosis, but are incapable of digesting the bacterium. The cell wall of the bacterium inhibits fusion of the phagosome with a lysosome by blocking a bridging molecule known as early endosomal autoantigen 1 (EEA1). The obstruction of the bridging molecule however does
Healthy lung tissue is predominately soft, elastic connective tissue, designed to slide easily over the thorax with each breath. The lungs are covered with visceral pleura which glide fluidly over the parietal pleura of the thoracic cavity thanks to the serous secretion of pleural fluid (Marieb, 2006, p. 430). During inhalation, the lungs expand with air, similar to filling a balloon. The pliable latex of the balloon allows it to expand, just as the pliability of lungs and their components allows for expansion. During exhalation, the volume of air decrease causing a deflation, similar to letting air out of the balloon. However, unlike a balloon, the paired lungs are not filled with empty spaces; the bronchi enter the lungs and subdivide progressively smaller into bronchioles, a network of conducting passageways leading to the alveoli (Marieb, 2006, p. 433). Alveoli are small air sacs in the respiratory zone. The respiratory zone also consists of bronchioles and alveolar ducts, and is responsible for the exchange of oxygen and carbon dioxide (Marieb, 2006, p. 433).
Drug resistance in mycobacterium tuberculosis (TB) has become a severe global health threat. The fight against TB is now facing major challenges due to the appearance of Multi-Drug Resistant Tuberculosis (MDR-TB) and more recently, the virtually untreatable Extensively Drug Resistant Tuberculosis (XDR-TB). MDR-TB are strains that are resistant to both top first-line drugs, Isoniazid and Rifampin, while XDR-TB are MDR-TB strains that are also resistant to any fluoroquinolone and one or more of 3 injectable drugs. With this new resistance, there emerges a great need to find new drugs that are as effective, yet bypass the problem of resistance. One method of research is to find new vulnerabilities of tuberculosis to use as new target sites of drugs. This method is highly expensive (Scheffler, Colmer, Tynan, Demain, & Gullo, 2013), and requires intense and lengthy research just to implicate the new target site. An alternative is to develop new drugs that work on the same already known target as the first-line drugs, but by a different mechanism, thereby bypassing the resistance of the TB to the drug.
Signs and Symptoms of Active Tuberculosis Mycobacterium tuberculosis (MT) is a slender, rod-shaped, aerobic bacillus which causes tuberculosis. Tuberculosis (TB) is an airborn infection which is transmitted via inhaling droplet nuclei circulating in the air. These droplets are expelled from the respiratory secretion of people who have active TB through coughing, sneezing, and talking (Porth, 2011). Some bacilli stay in the upper airway and are swept out by mucus-secreting goblet cells and cilia on the surface of the airway.
Tuberculosis as (TB) is caused by Mycobacterium tuberculosis. It is slow growing bacteria that thrive in areas of the body that are rich in blood and oxygen, such as the lungs. Tuberculosis develops when Mycobacterium tuberculosis bacteria are inhaled into the lungs. The infection usually stays in the lungs, but the bacteria can travel through the bloodstream to other parts of the body.
Only the smallest particles of the coal dust make it past the nose, mouth, and throat into the alveoli found deep in the lungs. The alveoli, or air sacs, are responsible for exchanging gases with the blood, and are located at the end of each bronchiole. Microphages, a type of blood cell, gather foreign particles and carry them to where they can either be swallowed or coughed out. If too much dust is inhaled over a long period of time, some dust-laden microphages and particles collect permanently in the lungs causing black lung disease.
My hypothesis on Tuberculosis is that it is a very deadly disease that causes a persons lungs to fill with blood. This can harm the body by making the body suffocate itself when the lungs fill with blood.
Myobaterium tuberculosis is a nonmoving, slow-growing, acid-fast rod transmitted via aerosolization (airborne route). People who are most often infected are those having repeated close contact with an infectious person who has not yet been diagnosed with TB (Ignatavicius and Workman, 2006). Therefore, when a person with active TB coughs, sneeze, laughs, sings, or whistles, droplet become air borne and may be inhaled by others. Far more people are infected with the bacillus than actually develop active TB. The bacillus multiplies freely when it reaches a susceptible site (bronchi or alveoli). The majority of the bacilli are trapped in the upper parts of the airways where the mucus-secreting goblet cells exist. An exudative response occurs, causing a nonspecific pneumonitis (Ignatavicius and Workman, 2006). With the development of acquired immunity, further growth of bacilli is controlled in most initial lesions. Bacilli can also spread by erosion of the caseating lesions into the lung airways -and the host becomes infectious to others. Cell-mediated immunity develops 2 to 10 weeks after infection and is manifested by a positive reaction to a tuberculin test. Skin testing for tuberculosis is useful test to detect. According to Universi...
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, in which bacteria may invade many parts of the body, such as the brain, the kidneys, and the spine. Mycobacterium tuberculosis is a rod shaped, aerobic bacterium that is resistant to destruction and can persist in necrotic and calcified lesion for prolonged periods and remain capable of reinstating growth (Porth, 2011). However, the most common target is the lungs (Wouk, 2010). The Tuberculosis bacteria severely damage the lungs that it is difficult for a person to breathe. According to Wouk, there are two main types of Tuberculosis. The first type is latent, which means a person carries the tuberculosis germ, but he or she is not sick and can not pass the germ on to the other person, and the other type is active tuberculosis.
Mycobacterium tuberculosis is a nonmotile, acid-fast, obligate aerobe. The bacilli are 2-4 um in length and have a very slow generation time of between 15 and 20 hours. The cell wall of the mycobacterium is unique in that it is composed mainly of acidic waxes, specifically mycolic acids. M. tuberculosis is unusually resistant to drying and chemicals, contributing to the ease with which it is transmitted.
Bacterial cells, like plant cells, are surrounded by a cell wall. However, bacterial cell walls are made up of polysaccharide chains linked to amino acids, while plant cell walls are made up of cellulose, which contains no amino acids. Many bacteria secrete a slimy capsule around the outside of the cell wall. The capsule provides additional protection for the cell. Many of the bacteria that cause diseases in animals are surrounded by a capsule. The capsule prevents the white blood cells and antibodies from destroying the invading bacterium. Inside the capsule and the cell wall is the cell membrane. In aerobic bacteria, the reactions of cellular respiration take place on fingerlike infoldings of the cell membrane. Ribosomes are scattered throughout the cytoplasm, and the DNA is generally found in the center of the cell. Many bacilli and spirilla have flagella, which are used for locomotion in water. A few types of bacteria that lack flagella move by gliding on a surface. However, the mechanism of this gliding motion is unknown. Most bacteria are aerobic, they require free oxygen to carry on cellular respiration. Some bacteria, called facultatibe anaerobes can live in either the presence or absence of free oxygen. They obtain energy either by aerobic respiration when oxygen is present or by fermentation when oxygen is absent. Still other bacteria cannot live in the presence of oxygen. These are called obligate anaerobes. Such bacteria obtain energy only fermentation. Through fermentation, different groups of bacteria produce a wide variety of organic compounds. Besides ethyl alcohol and lactic acid, bacterial fermentation can produce acetic acid, acetone, butyl alcohol, glycol, butyric acid, propionic acid, and methane, the main component of natural gas. Most bacteria are heterotrophic bacteria are either saprophytes or parasites. Saprophytes feed on the remains of dead plants and animals, and ordinarily do not cause disease. They release digestive enzymes onto the organic matter. The enzymes breakdown the large food molecules into smaller molecules, which are absorbed by the bacterial cells. Parasites live on or in living organisms, and may cause disease. A few types of bacteria are Autotrophic, they can synthesize the organic nutrients they require from inorganic substances. Autotrophic bacteria are either photosynthetic or Chemosynthetic. The photosynthetic bacteria contain chlorophyll that are different from the plant chlorophyll. In bacterial photosynthesis, hydrogen is obtained by the splitting of compounds other than water.
Fungal or mycobacterial infections are believed to occur when the lung cells (macrophages) that fight these infections are overwhelmed with silica dust and are unable to kill mycobacteria and other organisms [Allison and Hart 1968; Ng and Chan 1991]. About half of the mycobacterial infections are caused by Mycobacterium tuberculosis (TB), with the other half caused by M. kansasii and M. avium-intracellulare [Owens et al. 1988]. The. Nocardia and Cryptococcus may also cause infections in silicosis victims [Ziskind et al.]. 1976].
They’re out there! You can’t see them but they can see you. Right at this very moment they are living on and in your body, and there is nothing you can do about it!
Innate system critical main defense is the cellular component; there are several kinds of cells involved in the process. One of the crucial cells is the macrophage. ...
There are several ways to prevent tuberculosis. One is to control existing infections from those infected including people, pets, and cows. Unfortunately, more than 1/3 of the population has tuberculosis, making it hard to contain every case of tuberculosis. The BCG vaccine exists, but it is not very useful in countries like the US. The body’s defenses against tuberculosis are effective but fail once the immune system becomes suppressed. Antibiotics can be used to help prevent tuberculosis, but tuberculosis quickly grows resistant to antibiotics. Much needed research is being done to find a way to fight off and prevent tuberculosis.
Microbes are major key components in both are homes and industrial food preparation. There are number of lactic acid which is a form of bacteria which is a large group of beneficial bacteria used in certain foods while they are getting prepared such as yogurt, cheese, sour cream, butter milk and other type of fermented milk products. Things such as vinegars are produced by bacterial acetic acid fermentation. Yeast is also major use in the making of beer and wine and also for the leaving of breads. This also involves fermentations to convert corn and other vegetable carbohydrates to also make beer, wine or gasohol but also bacteria is the agents of are other foods. Other fermented foods will include things such as soy sauce, olives and cocoa. (Microbes and human life, 2013) Single cell proteins are known as dried cells of microbes which are used in protein supplement shacks. They are also called “novel food” and “minifood”. The production of this requires micro-organisms which then serve as the protein source and then the substrate which is biomass which they grow on them. There are a number of both these sources that we are able to use for the production of single cell protein (SCP). The micro-organisms used belong to the following groups of Algae, Fungi and bacteria. (Slide Share, 2012)