literature review

Satisfactory Essays
Parkinson’s disease is found mostly in adults over the age of 50. A failure of the central nervous system where the brain cells are being slowly destroyed that produces dopamine which allows controlling of our motor skills. The lack of dopamine can cause problems to the body and show symptoms of loss of movement, shivering and shaking, and also even paralysis. Coffee is known to be one of the most addictive drugs in the world and even though it might sound harmful it can also provide benefits to the human body. Throughout this review it hypothetically shows the correlation between the consumption of caffeinated coffee and how it can reduce the symptoms or even prevent the risk of having Parkinson’s disease. These next six literature reviews will provide its hypothesis and studies based on this research.
The first article written and reviewed by multiple authors explains the connection of consuming caffeine reduces the chance of Parkinson’s disease. Even though the physiological aspect of having caffeine is not fully understandable but caffeine protects neurons in the 1-methyl-4-phenyl 1,2,3, 6-tetrahydropyridine (MPTP) neurotoxin model of PD by blocking the adenosine A2A receptor (ADORA2A) (Saaksjarvi, et al., 2008). In order to find the results to this experiment the researchers did a five case-control study, two of them being cohort, and came to conclusion that there was an inverse reaction of the caffeine towards the disease (Saaksjarvi, et al., 2008). These results provided proof on how caffeine does help reduce the chance of getting Parkinson’s disease even though they fully didn’t understand on why it does. There are also experiments on how caffeine helps the movement with patients that has Parkinson’s disease. They provide...

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...ogy (AAN). (2012). Coffee may help some Parkinson’s disease movement symptoms, research suggests. ScienceDaily.
American Journal Epidemiology. (2004) Coffee Consumption, Gender, and Parkinson’s Disease Mortality in the Cancer Prevention Study II Cohort: The Modifying Effects of Estrogen
160 (10):977-984.doi: 10.1093/aje/kwh312

Hamza Taye H., et al. (2011) Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson’s disease Modifier Gene via Interaction with Coffee, 7
President and Fellow of Harvard College. (2002) Caffeine reduces risk of Parkinson's.

Saaksjarvi, K., Knekt P., Rissanen H., Laaksonen MA., Reunanen A., Mannisto S. (2008) Prospective study of coffee consumption and risk of Parkinson’s disease, 62, 908-915
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