fault

1033 Words5 Pages
INTRODUCTION
Vitamin D deficiency is now a critical issue because of its high prevalence and side effects. An estimated 1 billion people worldwide are suffering from inadequate serum vitamin D level (1).Vitamin D plays an important role in children's bone health (2). Vitamin D deficiency is responsible for secondary hyperparathyroidism and skeletal abnormalities such as osteopenia, osteoporosis and osteomalacia (3).Numerous recent studies have also reported the relationship between lower serum vitamin D status and cardiovascular diseases, hypertension, infections, autoimmune diseases and common cancers (4-6).
In recent years the prevalence of obesity (Body Mass Index (BMI) ≥95 percentile for age and gender) has increased dramatically. The obesity rates almost quadrupled for 6 to 11 year old children and tripled for 12 to 19 year in the past 30 years(7,8).Many studies have shown that there is an association between obesity and lower serum 25-hydroxyvitamin D (25(OH)D) level that is the best indicator for vitamin D status(9-11).It also has been suggested to treat obese children who are vitamin D deficient with higher doses (two to three times higher) of vitamin D to achieve adequate vitamin D level(12).
The prevalence of vitamin D deficiency in Iranian obese children has not been well documented. Therefore, we designed a study to examine the serum vitamin D status of obese and non-obese Iranian healthy children and their therapeutic response to identical Vitamin D therapy (50000 IU of vitamin D3 once a week for 6 weeks)(12).
METHODS AND PROCEDURES
Study subjects
This study subjects were 90 (45 obese,45 non-obese) Iranian children aged 2-14 years referring to endocrine clinic, vaccination clinic and general clinic of Children Medic...

... middle of paper ...

...group (p<0.05) (Table4).

Vitamin D status post therapy:
Following oral treatment of deficient and insufficient children(obese:44, non-obese:30) with 300000 IU of vitamin D3 during 6 weeks (50000 IU as a pearl ,once a week), the proportion of vitamin D deficiency became 8/43(18%) obese vs. 1/30(3%) non-obese and the proportion of vitamin D insufficiency became 16/43(37%) vs. 0/30(0%) non-obese(Table5).

Post treatment serum 25(OH) D status was significantly lower in obese (p<0.001).There were also significant differences between the obese and the non-obese cohorts for post treatment phosphorus, PTH and Alkaline phosphatase (p=0.02,p=0.01 and p<0.001)(Table6).

Correlations:
There was a significant negative correlation between BMI and baseline serum 25(OH) D status (r=-0.39,p<0.001) and also between BMI and post treatment serum 25(OH) D status (r=-0.55 , p<0.001).

More about fault

Open Document