Cancer and Gene Therapy Gene therapy is an experimental technique that allows doctors to insert a gene into a patient’s cell rather than using drugs or surgery. Gene therapy is a process of which defective or undesired genes in the body with “normal” genes. A vector is re-engineered to deliver the gene to a target cell. Then the gene is transferred to the cell’s nucleus and must be activated in order to function. The main focus of gene therapy is to replace a lost or improper gene with a new functional copy into a vector that is inserted into the subject’s genome by way of penetrating its DNA.
Gene Therapy is a modern treatment which uses genes to treat or prevent genetic diseases. It is a process of which DNA is used as a drug to treat a disease by delivering therapeutic DNA into a patients cell. The mutated gene is replaced by a healthier, functional/therapeutic gene which corrects and converts the cells lacking in protein or faultiness. Our future is based behind our genes in the body and scientists are trying to move away from drugs as a solution. Gene therapy is revolutionising the world of medicine and it could be the biggest and most helpful treatment created.
There are a few methods of altering cells in gene therapy. The first method is in vivo. The in vivo method is where the cells are altered inside of the body. For the in vivo method to work accurately, there needs to be a certain way for the genes to reach the target cells (a ve... ... middle of paper ... ...ays inside of the cell until it is evicted by the body’s immune system. Cancer can be cured with gene therapy by many methods.
Gene therapy is the delivery of a correct version of a mutated gene to a cell, where its expression will produce the normal protein and restore normal cellular function. The mutated gene must be delivered to the nucleus of the cell. (2) There are essentially two forms of gene therapy, somatic gene therapy and germline gene therapy. Somatic gene therapy involves the manipulation of gene expression in cells that will be corrective to the patient but not inherited by the next generation. (4) Germline gene therapy involves the replacement of defective genes in the germline cells, which contribute to the genetic heritage of the offspring.
Human Gene Therapy: Gene Therapy can be defined as an experimental technique that uses genes to prevent or perhaps treat diseases. It works out by allowing doctors to treat the disorder by inserting a gene into a patient’s cell and not using surgery or drugs. There has been several approaches to gene therapy such as; launching a new gene into the cell to help fight a disease, inactivating a mutated gene that is doing harm to the body, and replacing a defective gene with a “corrective” copy of that particular gene. Gene therapy could have the possibility of treating numerous diseases but it is currently being tested for diseases that still do not have a cure. It was design to introduce new genetic material into cells to help “correct” mutated genes or help the cell produce a necessary protein.
Many diseases seen today are the result of a defective gene in the DNA of the patient and can not be cured using the traditional methods such as antibiotics and antiviral medication. The victims are now looking to gene therapy as a potential cure for their problems. Bob Williamson introduces us the concept, procedures, and problems associated with gene therapy in his article, ¡°Gene Therapy¡±. Along with the appearance of the recombinant DNA technology, it becomes possible for human beings to isolate, study, and change gene in the laboratory. Gene Therapy is the process of replacing a defective gene inside a patient¡¯s DNA with a working gene that will produce the correct gene products.
By administration of DNA rather than a drug, many different diseases are currently being investigated as candidates for gene therapy. These include cystic fibrosis, cardiovascular disease, infectious diseases such as cancer and AIDS. This new foundation of unprecedented prospects should be preceded with caution, and should only be used in the developmental treatments of diseases to avoid abuse. Gene therapy assists in explaining the nature of infectious diseases, in particular, the interactions between an invading microbes and their host’s immune defense system. A gene must be carried by a “vehicle”, or vector in order for the therapeutic gene to counterattack the disease.
Critics may argue that there are moral and ethical problems associated with this novel technique, but for the most part scientists realize the importance this advancement will have. Gene therapy may be the key to curing dozens of diseases, and has endless possibilities, but more research is needed before its safe or accepted as common practice.
The definition of gene therapy is the introduction of genes into existing cells to prevent or cure a wide range of diseases (Jaroff, 1996). Gene therapy has two possibilities of disease treatment, somatic gene therapy and germline gene therapy. Somatic gene therapy involves the manipulation of gene expression in cells that will be corrective to the patient but not inherited to the next generation. Germline gene therapy involves the genetic modification of germ cells, which pass the change on to the next generation (Wilson, 1998). Somatic gene therapy is currently being researched more aggressively due to ethical and technical complications with germline gene therapy.
Germ line gene therapy treats the gametes or an embryo, which would be used in the case of in vitro fertilization. The difference between somatic and germ line gene therapy may seem to be subtle; however, the alterations obtained through germ line therapy are not only found in that generation, but are passed on to the individuals progeny. That has serious repercussions when it comes to discussing the ethics of using germ line therapy. Presently, similar techniques are being examined for both somatic and germ line gene therapy, but germ line therapy is more difficult (Coults). This is not to say that somatic cell gene therapy is easily accomplished.