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Essay on dna repair
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Cells need to be small which means there must be space between them. If the cells get into contact they die. This is called Contact Inhibition; it’s how cancer-fighting drugs kill cancer cells. The purpose of the drugs is to put in the body cells that get in contact with the cancer cells and destroy them. The drugs also prevent DNA replication. The cells are most vulnerable when they are rapidly dividing. Cancer-fighting drugs fall into several different classes.
One of these classes is DNA binding agents. They form a covalent bond with the DNA or stick to it noncovalently very tightly. A covalent bond is a chemical bond. It involves sharing of electron pairs in the middle of atoms. These electron pairs are known as shared pairs or bonding
However, the atoms are arranged a little differently. Two molecules that have this type of relationship are called isomers.
Covalent compounds are formed when two or more non-metals react together. The covalent compound is actually made of molecules, and the name given depends on the structure of these molecules. Prefixes, like di- for two, tri- for three, tetra- for four, and so forth, are frequently used. Thus, NO2 is nitrogen dioxide and N2O4 is dinitrogen
Chemotherapy is the treatment of a tumor with chemical agents to reduce mass or eradicate a tumor completely. There are certain mechanisms by which chemotherapy inhibits cancer. The first mechanism is cell death by cytotoxicity. Some chemical agents in certain amounts are toxic to cells. The cells die due to the toxic...
..., while a cell undergoes cell cycle, when a cell comes in contact with another cell, it stops reproducing. However, cancer cells continue to duplicate repeatedly until there is a mass of cells or a tumor to form (see figure 9). Lastly, in cell division when there is a mutation or abnormality in the DNA, a normal cell stops dividing. However, a cancerous cell will continue to duplicate and form mutations (“Cell Biology and Cancer”). Also, cancer cells are harmful because they grow and duplicate with complete disregard to the functions and limitations of the body (see figure 10). Also, cancerous cells have the ability to spread through metastasis throughout parts of the body through the bloodstream. In terms of similar behavior to that of normal cells, cancerous cells also duplicate, but at a very different rate ("Cancer Cells vs. Normal Cells: What's Different?").
To understand how immunotherapy works it helps to know how your immune system works to fight against cancer. Cancer cells have substances on their surfaces called tumor antigens that raise an alarm in the immune system that says cancer is present. Antigen presenting cells ( APCs) roam the body seeking out and ingesting tumor antigens. The APCs then activate B cells and T cells. The B cells differentiate into plasma cells and secrete antibodies that bind to the tumor cell and mark them for elimination ( a humoral immune response). When T cells are activated they proliferate and undergo expansion, seek out, and destroy cells bearing the specific tumor antigens ( a cellular immune response). Sometimes your immune response does not destroy all of the cancer cells and this r...
“When someone has cancer, the whole family and everyone who loves them does, too.” – Terri Clark
Cancer occurs when abnormal cells grow out of control; the cells don't die, instead they continue to divide into other abnormal cells. These abnormal cells invade other tissues; this type of cancer is called metastatic cancer. If these abnormal cells get into the lymphs or the blood stream they spread and replace all other normal cells, eventually taking over the entire body and killing the person. These abnormal cancer cells are caused by damaged DNA due to sun exposure, cigarette smoke, lifestyle choices, or inherited damaged DNA. (12)
“Since 1990, over 6 million Americans have died of cancer, more than the combined casualties from the Civil war, WWII, and the Vietnam and Korean conflicts combined” (Faguet, p. 5). According to American Cancer Society projections, there were 1,529,560 new cases of cancer in 2010. Cancer is becoming more and more common around the world. New cancers are constantly being discovered. Researchers are finding new ways to detect cancer and treat it so that the fatality rate does not rise. However, there are some cancers that researchers have not yet discovered a cure for. It is very important for Cancer Research to continue so that one day these cancers will no longer be a treat.
The East Pennsboro elementary school raised money for a statue at a local park. The statue was a ring of children that were holding hands. There was one child missing; the link was broken. The statue was dedicated to East Pennsboro students that did not make it to their graduation. My sophomore year of high school inspired this piece of artwork.
In contrast, any molecule which forms a covalent bond by donating a pair of electrons is called a nucleophile. Nucleophiles are usually rich in electrons and seek out positive atoms or molecules, which is usually located in the nucleus of an atom – hence the name Nucleophile.
Cancer develops when cells in a part of the body begin to grow out of
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...
Cancer is related to the cell cycle because if a cell does not meant the checkpoint requirements and still continues through the cycle, it will become uncontrollable. During the synthesis stage of interphase, while the DNA should be replicating, an error can occur, which will lead to a mutated cell. Proteins that control transcription are often the cause because of the changed sequence. This one mutation can lead to an army of mutated cells. These cells can lead to tumor development and cancer. The P53 is a gene that codes for a protein that suppresses tumors. A tumor suppressor is a gene that protects a cell from one step on the path to cancer. It is extremely important in helping kill cells that could become cancerous. If there is a mutation to this gene, it will stop protecting you from cancer. Proto-oncogenes code for positive cell cycle regulators, but when mutated, turn into oncogenes, or genes that have the potential to become cancerous. Cancerous cells lose their specialized functions and produce more quickly. They ignore signals that tell them when to start and stop dividing. Eventually, they can take over tissues and grow without being regulated. Cancer cells have insufficient internal regulators and also cannot program cell death among mutated cells, this process is called apoptosis. When cancer cells don’t die, they keep dividing instead which can produce tumors, masses of rapidly dividing cells that can damage surrounding tissues. When cancer moves into other parts of the body and forms secondary tumors, it is called metastasis. Tumors that develop can be malignant, cancerous and invade and destroy healthy tissue, or benign, noncancerous and does not invade any other part of the body. Sometimes, cancerous cells can break away from a tumor and enter the bloodstream, which allows them to travel throughout the
From these properties of bonds we will see that there are two fundamental types of bonds--covalent and ionic. Covalent bonding represents a situation of about equal sharing of the electrons between nuclei in the bond. Covalent bonds are formed between atoms of approximately equal electronegativity. Because each atom has near equal pull for the electrons in the bond, the electrons are not completely transferred from one atom to another. When the difference in electronegativity between the two atoms in a bond is large, the more electronegative atom can strip an electron off of the less electronegative one to form a negatively charged anion and a positively charged cation. The two ions are held together in an ionic bond because the oppositely charged ions attract each other as described by Coulomb's Law.
The National Cancer Institute says that one in two will get cancer during their lifetime. The cancer drug is a key part in the treatment for these people. As of now, there are more than 100 cancer drugs in use. These drugs can kill cancer cells or at least slow down the growth. The difference between regular cells and cancer cells is that cancer cells divide rapidly, while healthy cells don’t. These drugs aren’t perfect and may also hit the normal cells, which can cause many side effects. Many of the cancer cells can resist the cancer drugs. These drugs are usually given in a tablet form, injection, or infusion by a device called a port. The port inserts it into the blood vessel or body cavity.