What Are the Signs and Symptoms of Hemophilia?

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Hemophilia is an inheritable bleeding disorder that almost always affects males and is caused by either non-existent or low levels of clotting proteins called factors. There are 13 different kinds of these factors, called coagulation factor and when they are combined with platelets and fibrin, they create a clot which stops bleeding. They are labeled I through XIII and it is the lack of VIII, IX, or XI factors that cause the disorder. If even one of these factors are missing or present but at low levels, this can cause blood clotting problems and a proper clot will not be able to form. This genetic disorder is a result of the change or inheritance of genes from the mother or father in the womb. ( Homecare for the Cure)

Hemophilia occurs when a defect in the X chromosome takes place which is one of the sex chromosomes. Hemophilia affects the entire X chromosome and is inherited in an X-linked recessive pattern. Hemophilia A’s VIII is in the F8 gene which is located on xq28. Hemophilia B’s IX is in the F9 gene which is located on xq27.1-27.2. Hemophilia C’s XI gene is located on 4q35. (Genetics Home Reference)

When most people get a cut, it heals naturally and isn’t a big deal, but hemophiliacs are the exact opposite. Their blood lacks the adequate ability to clot because they are missing either the VIII, IX, or XI clotting factor. The first step in the clotting process is for platelets to go to the wound and plug up the hole. Platelets are sticky blood cells that circulate throughout the bloodstream. When these cells plug up a cut, they release chemicals that attract more platelets to the site. These chemicals are known as clotting factors. People with hemophilia are either missing or have low levels of...

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"KidsHealth." Hemophilia. 08 Jan. 2014 .
"Treatment." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention. 08 Jan. 2014 .
"Welcome to the National Hemophilia Foundation." Welcome to the National Hemophilia Foundation. 08 Jan. 2014 .
"What Are the Signs and Symptoms of Hemophilia?" Hemophilia Signs and Symptoms, Bleeding, Bruising. N.p., n.d. Web. 08 Jan. 2014. .
"What Is Hemophilia?" - NHLBI, NIH. 08 Jan. 2014 .
"World Federation of Hemophilia." World Federation of Hemophilia. 08 Jan. 2014 .
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