Types Of Adhesive

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TYPES OF PATCHES- 11,37,38,39 a) Single layer drug in adhesive- In this type of the patches , the drug and other excipients are directly present in the adhesive which is responsible for the adhere the skin and release of the drug. The rate of drug release is depending on the diffusion across the skin. The adhesive layer is surrounded by a temporary liner and a backing. FIG. 1: SINGLE-LAYER DRUG-IN-ADHESIVE19 b) Multi -layer drug in adhesive-This type of patch is similar to the single layer drug in adhesive patch because the drug and other excipients are incorporated in the adhesive layer. In multilayer patch one layer is for immediate release of the drug and other layer is for controlled release of the drug. The adhesive layer is surrounded by a temporary liner and a backing. FIG. 2: MULTI-LAYER DRUG-IN-ADHESIVE19 c) Vapour patch- In this type of patch the role of adhesive layer not only serves to adhere the various layers together but also serves market, commonly used for releasing of essential oils in decongestion. Various other types of vapor patches are also available in the market which are used to improve the quality of sleep and reduces the cigarette smoking conditions. d) Reservoir system- the reservoir transdermal system has a separate drug layer. In this system the drug reservoir is packed between the two layers one is impervious backing layer and other is a rate controlling membrane. In the drug reservoir compartment, the drug can be in the form of a solution, suspension, gel or dispersed in a solid polymer matrix. The whole system is supported on the impermeable metallic backing. ... ... middle of paper ... ...mount of drug permeated is plotted against time. Fig-K.C. Method of In-vitro permeation studies1 C- Skin irritation study-Skin irritation and sensitization testing can be performed on healthy rabbits (average weight 1.2 to 1.5 kg). The dorsal surface (50cm2) of the rabbit is to be cleaned and remove the hair from the clean dorsal surface by shaving and clean the surface by using rectified spirit. The patch can be applied over the skin. The patch is to be removed after 24 hr and the skin is to be observed and classified into 5 grades on the basis of the severity of skin injury. D-Stability test-Stability studies are to be conducted according to the ICH guidelines by storing the TDDS samples at 40±0.5°c and 75±5% RH for 6 months. The samples are withdrawn at 0, 30, 60, 90 and 180 days and analyze suitably for the drug content .
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