Tuberculosis (TB) is an infection that can attack any part of the body, but it is normally found in the lungs (Huether, McCance, Brashers and Rote, 2008,). TB is an infection caused by a acid-fast bacillus also know as Mycobacterium tuberculosis (Huether et al. 2008) It is one of the leading causes of death in Asia, China, Indian, Indonesia and Pakistan (Huether et al. 2008). These countries show that in most cases the incidence rate is highest in young adults, and are usually the result from re-infection in recent infections. The spread of TB is attributed to the emigration of infected people from high-prevalent countries, substance abuse, poverty, transmission in crowd places, and the lack of proper medical care for the infected individuals (Huether et al. 2008).
Tuberculosis is transmitted from person to person through airborne droplets, when a person that is infected with TB coughs, sneezes, talks, and/or sings letting tiny droplet to be released into the air(Bare, Smeltzer, Hinkle, and Cheever, 2008). TB cannot be spread through touching inanimate objects, food, or drinks (Bare et al. 2008). The person must be in the same area an affected individual is in and inspirate the droplets to be affected. Once the bacillus is inspired into the lungs, the bacilli start to multiply causing lung inflammation also known as nonspecific pneumontis (Huether et al. 2008). To cause an immune response the bacilli will travel through lymphatic system and become lodged in the lymph nodes (Huether et al. 2008). Lung inflammation causes the activation of the alveolar macrophages and neutrophils (Huether et al. 2008). Granulomas, new tissue masses of live and dead bacilli, are surrounded by macrophages, which form a protective wall. They then transform into a fibrous tissue mass, the central portion is called a ghon tubercle (Bare et al. 2008). The bacterial then necrotic, forming a cheesy mass, this mass may become calcified and form a collagenous scar (Bare et al. 2008). At this point, the bacteria becomes dormant and there is no further progression of the active disease. The disease can become active again by re-infection or activation of the dormant bacteria (Bare et al. 2008).
TB can be classified as latent or active (Bare et al. 2008). TB that is a latent is bacilli that are isolated with a tubercle can remain, dormant, causing no symptoms. Active TB occurs when live bacilli escape into the bronchi or if the immune system is weaken by diseases such as HIV or Cancer (Bare et al.
The immunologic events that are happening at the local level during Carlton's acute inflammatory response would be:
Also contributing to the virulence of the bacteria are the exotoxins including invasive adenylate cyclase, tracheal cytotoxin, and lethal toxin. Invasive adenylate cyclase reduces local phagocytic activity as well as acting as a hemolysin. Tracheal toxin affects the ciliated respiratory epithelium by inhibiting the ciliary beating. This kills the cells and causes them to be eliminated from the mucosa. Tracheal toxin also stimulates the release of IL-1, which causes fever. Lastly, lethal toxin causes inflammation and local necrosis at infection sites.
Signs and Symptoms of Active Tuberculosis Mycobacterium tuberculosis (MT) is a slender, rod-shaped, aerobic bacillus which causes tuberculosis. Tuberculosis (TB) is an airborn infection which is transmitted via inhaling droplet nuclei circulating in the air. These droplets are expelled from the respiratory secretion of people who have active TB through coughing, sneezing, and talking (Porth, 2011). Some bacilli stay in the upper airway and are swept out by mucus-secreting goblet cells and cilia on the surface of the airway.
Tuberculosis, like common colds, is spread through coughs and sneezes. A person can’t get tuberculosis by sharing drinks and food because the bacteria cannot grow on
Hepatitis is the inflammation or swelling of the liver. The inflammation can happen from different injuries or viral forms of a disease. People who experience hepatitis have the symptoms of malaise, nausea, vomiting, loss of appetite, fever and jaundice. There are six known forms of Hepatitis which are Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, Hepatitis E and Hepatitis G. The presence of hepatitis in the body can be very risky and cause severe death if not taken care of. Hepatitis is a severe issue that affect many people around the world like third world countries and cross contamination can occur mainly in health care places due to the exposure of patients with the disease and accidents handling blood or instruments, Hepatitis A,B,C,D,E and G are distinct diseases that differ in transmission and vaccines to prevent them or cure them.
One of the first steps to treating Tuberculosis is identifying which form has developed in the body. The two forms that could progress in the body are latent Tuberculosis infection and active Tuberculosis infection (CDC, Morbidity and Mortality Weekly Reports). Latent Tuberculosis is the dormant form of the bacteria, meaning that it is inactive and doesn?t cause an infectious reaction in the body. Even if the latent form enters the body, treatment should be sought (CDC, Morbidity and Mortality Weekly Reports). Latent Tuberculosis can become active Tuberculosis easily though, especially if the immune system is compromised by another infection, like HIV (CDC, Morbidity and Mortality Weekly Reports). Active Tuberculosis infects the body immediately. Symptoms show in the body meaning the bacteria is effecting the cells of the body. Identifying the form is important because treatment is dependent upon it. Testing for TB involves a skin test, usually within seven work-days of contact with the bacteria. Without knowing what is in the body, the drugs won?t be as effective and might even cause drug-resistance.
breathe the same air can become infected with the TB germ. People who do work
Person, A. & Mintz, M., (2006), Anatomy and Physiology of the Respiratory Tract, Disorders of the Respiratory Tract, pp. 11-17, New Jersey: Human Press Inc.
Tuberculosis is an air-borne disease, hence, it can be passed from an infected person to a healthy individual through coughing, sneezing and other salivary secretions. Tuberculosis is caused by the transfer of Mycobacteriun Tuberculosis (M. Tuberculosis) also known as Tubercle Bacillus, a small particle of 1-5 microns in diameter, due to the small size, when an infected person sneezes or coughs, about 3,000 particles are expelled. M. Tuberculosis responsible for tuberculosis is able to stay in the air for a long period of time (about 6hoursAnother way of acquiring Tuberculosis is by drinking unpasteurized milk, milk straight from cow, although this is not a common mode of transmission, it can be found in rural areas. Ingestion of contaminated cow milk transmits Mycobacterium Bovis, the animal form which is still potent enough to cause tuberculosis in humans. ). Tuberculosis transmission is affected by exposure, socioeconomic status of person, proximity, immune status of uninfected individual (%&&%&? CDC).
Malaria (also called biduoterian fever, blackwater fever, falciparum malaria, plasmodium, Quartan malaria, and tertian malaria) is one of the most infectious and most common diseases in the world. This serious, sometimes-fatal disease is caused by a parasite that is carried by a certain species of mosquito called the Anopheles. It claims more lives every year than any other transmissible disease except tuberculosis. Every year, five hundred million adults and children (around nine percent of the world’s population) contract the disease and of these, one hundred million people die. Children are more susceptible to the disease than adults, and in Africa, where ninety percent of the world’s cases occur and where eighty percent of the cases are treated at home, one in twenty children die of the disease before they reach the age of five. Pregnant women are also more vulnerable to disease and in certain parts of Africa, they are four times as likely to contract the disease and only half as likely to survive it.
Tuberculosis is transmitted by inhalation of aerosols containing the tubercle bacilli. The required inoculum size for infection is usually high, but easily occurs with exposure to a patient who is currently infected. The products of dried aerosols, droplet nuclei, are particularly infectious because they remain in the air for an extended time, and upon inhalation easily move to the alveoli. The severe damage related to infection is caused by the reaction of the host. The tuberculosis infection has two phases, primary and secondary.
Wines, M. 2007. Virulent TB in South Africa may imperil millions. New York Time. January 8. Accessed online at http://www.nytimes.com/2007/01/28/world/africa/28tuberculosis.html?pagewanted=all
Being all members of the human race surely we have all sympathized for the less fortunate; whether it was for what they had or what they didn’t. There is a condition that most have never considered, and probably have never heard of. Imagine big white and red spots that decorate every part of your body so that they can’t be hidden. On the inside you have a painful sinus infection and after a while a loss of peripheral nerve sensation so bad that your hands and feet go numb. You could go blind or you could loose your nose, ears, or even legs to amputation. Unfortunately the physical ailments are the best part. Throughout history leprosy sufferers have been cast off from society with as much concern that dead bodies are sent to graves.
Tuberculosis has plagued mankind for a long time. This disease, which was previously believed to be eradicated, has once again shown up and begun attacking the lives of many humans. Tuberculosis infects a third of the population and kills a fraction of them. Many approaches have been used including different varieties of infection control, bodily defenses, and treatments to try to protect humans from tuberculosis. The best way to prevent tuberculosis infections is to contain the source of tuberculosis. The most common source of tuberculosis infection is from infected humans. By diagnosing, containing, and treating people with latent tuberculosis before they get active, contagious tuberculosis, tuberculosis can be quickly contained. Once someone has been diagnosed with TB, they should be placed under isolation.
Researchers have also identified a list of other factors associated with TB transmission such as environmental, organism and host factors, but these unfortunately, are outside the scope of the present paper. 16