Throughout this brief article Seung Lee et al. delves into the effectiveness of early infliximab usage with maintenance and induction therapy in Crohn’s disease. Essentially the study is directed at
Many people have suffered some form of gastrointestinal discomfort in their life. For patients with Crohn’s Disease this can be a daily occurrence that greatly affects their everyday lives. Crohn’s disease is an inflammatory disease that targets the gastrointestinal tract. Crohn’s most commonly will occur in the lower GI tract involving the small and large intestine and colon but can be found anywhere throughout the GI tract from mouth to anus. Crohn’s is lumped together in a larger group of illnesses more commonly referred to as inflammatory bowel disease. ("About crohn's disease," 2009)
Rheumatoid arthritis is a disease that has direct involvement with the immune system. This disease is considered to be degenerative and currently the only thing that can be done is manage the painful symptoms and suppress the self targeting actions by using immune suppressing drugs. The cause of rheumatoid arthritis is mostly unknown but there is a high amount of evidence that there are genetic predispositions for the disease. This being said however there are also environmental factors to asses these include, bacteria, viruses, fungi and other environmental factors. Doctors primarily use a physical examination to first suspect R.A. then send for blood work to confirm. There are many aspects to this disease and many questions left unanswered, the treatments available now are only temporarily and can in some cases cause more problems than benefits. Lab experiments and clinical trials are currently showing some great results and could within our lifetimes cure many autoimmune diseases including R.A..
Crohn’s is an incurable inflammatory bowel disease that can damage the intestine over time; Crohn’s disease can cause painful gas, diarrhea, rectal bleeding, and the inability to eat normally.
Turner, B. J., Newschaffer, C. J., Zhang, D., Fanning, T., & Hauck, W. W. (1999). Translating clinical trial results into practice. Annals of Internal Medicine, 130(12), 979-986.
Crohn’s Disease is a chronic inflammatory condition of the gastrointestinal tract. It is one of two disease under the category “IBD”, or Irritable Bowel Disease, the other being Ulcerative Colitis. Crohn’s is named after Dr. Burrill B. Crohn, who, along with Dr. Leon Ginzburg and Dr. Gordon D. Oppenheimer, described the disease back in 1932. Crohn’s commonly affects the ileum and the beginning of the colon, but it can affect any part of the gastrointestinal tract, from the mouth to the anus. Crohn’s can affect the entire bowel wall, while it can also “skip” over patches of the diseased intestine, leaving some unaffected parts of the area. In a healthy gastrointestinal tract, there are many harmless bacteria, which aid in digestion. The immune system will attack and kill any foreign invaders. In Crohn’s patients, the normal bacteria are mistaken for invaders, and the immune system responds. Cells will travel out of the blood and to the intestines, in turn producing inflammation, the normal response. The inflammation does not go down, which leads to chronic inflammation, ulceration, and a thickening of the intestinal wall. These lead to the patient’s symptoms.
Hi, Hannah :) my nam's Caroline. As for your questions, at the moment there is no known cure to Crohn's Disease, but there may be one in the future as there are inprovements and discoveries in medicine and technology. Yes, researchers are currently searching for ways to cure Crohn's and treat it, there are actually some ways to treat it now using anti-inflammatory drugs and inhibitors. As for the cause of Crohn's, it's unknown but doctors and researchers believe that is developed through abnormal responses in the immune system and bacteria in the intestines. Hope this all answered your questions
Aspirin, despite some of its affect to be a benefit to people with cardiovascular disease, is believed to have somewhat of an opposite affect when dealing with the gastrointestinal tract. The main objective for this paper was to see if the use of aspirin and or any other type of inflammatory medications had any effect on gastro intestinal bleeding. A 20 year prospective cohort study was used to effectively survey, and monitor a sample of individuals who reported using aspirin and a list of other inflammatory medications that the study deemed as close to aspirin as possible. In order to become a subject in the study, subjects were of male sex, specifically chosen from the HPFS (Health Professionals Follow-up Study) who chose to report their
The main issue Abramson highlights in the CLASS study is that the authors only reported the first six months. A majority of the observed complications occurred in the second six months, and the researchers pushed to exclude this data which would indicate that Celebrex could actually cause more stomach problems. The authors also combined categories that were initially supposed to be separate, in order to produce significance (Abramson, Kindle 688-702).
Crohn's disease is a autoimmune disorder, causing the body's immune system to begin to attack healthy cells in your gastrointestinal tract causing inflammation and having an effect on all layers of the intestinal wall.  Crohn's disease commonly effects the small intestine causing sores, skin tags and ulcers to grow. The amount of youth and children that have been diagnosed by Crohn's disease is increasing dramatically becoming one of the most frequent genetic Inflammatory bowel diseases (IBD) to occur with more than 61,000 Australians ages between 15 and 30 years suffering from inflammatory bowel diseases including Crohn's  and this is why it is a significant health issue for Australia youth and it is effecting individuals health and human development.