Traumatic Brain Injury

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Traumatic brain injury (TBI) is a global health epidemic, widely recognized as diffuse axonal injury and a pervasive neurodevelopmental disorder in children. Typically characterized by external forces and pathologic change, TBI encompasses a broad range of etiologies and subsequent symptomatology. The Brain Injury Association of America cites TBI as the leading cause of disability and death in children and adolescents in the United States (BIAA, 2015), with reported estimations from various sources including emergency room visits, hospital admissions, sports related injuries, falls, motor vehicle accidents, and death. Incidence rates are difficult to ascertain and are significantly underestimated due to a broad classification of symptoms …show more content…

Since TBI is broadly classified to include most brain-related injuries, methods to universally standardize TBI have not been implemented, which presents a concern when identifying patients, clinical symptoms, severity of trauma , neurologic impairment, and treatment strategies across large demographics. Due to a broad classification, TBI mortality rates have been attributed to other brain-related disorders, which presents a grave concern when symptoms can occur post-injury, as in clinically silent secondary insults or latent inflammatory responses, or present later in life as a chronic …show more content…

Diagnosis is typically defined as mild, moderate, or severe based on radiologic evidence and pathologic change. The current literature for pediatric TBI correlates advanced imaging techniques and cognitive deficits as reliable determinants to assess progression. Novel identification and treatment strategies at the molecular and cellular levels are limited to clinical drug trials that target synaptogenesis and cellular activation. Amavii, a biomedical device start-up company, has developed a neuro-trauma simulator to study TBI at the cellular level by exposing neurons to shock waves of varying pressure frequencies. The company objective is to study neurons from different areas of the brain that were exposed to traumatic injury and correlate a response to structural or functional abnormalities characterized by pathological change and cognitive disability. This revolutionary research would be a pivotal diagnostic tool and an indicator of injury progression in the developing

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