Tp53 Mutations In Iraq

Biochemistry of Uranium Induced Cancer Cases in the Geographical Region of Iraq

Iraq has many different cases of cancer, including bladder cancer. Uranium is one factor which can cause cancer. This kind of cancer increased because Iraq was exposed to war, which used uranium. The researchers worked hard to analyze and check for the mutation of the gene TP53 which offers a way to investigate the epidemiology, etiology, and pathogenesis of human cancer. There are multiple mutations that can occur due to differences in exposures to TP53. The pattern of TP53 mutations in Iraq were determined by TCC. Some studies were done on the Iraqi population after the wars, which was the result of a hazardous environmental condition. Many people were breathing

The difficulty is finding a cohort of people who were not exposed. When Iraq gets sand storms, all the sand that was in a polluted area now travels to different regions and effects the population. In Fallujah, Iraq after using uranium the researchers found an increase in cancer rates and infant deaths. This is why bladder cancer is the most common type of cancer in Iraq. Scientists uses the TP53 gene as a biomarker to discover carcinogenesis susceptibility within humans when they are exposed to ionizing radiation. Scientists discovered that the mutation can happen in tp53 that causes bladder cancer which is the G→A transition. Also, radioactive energy can cause damage to double-stranded DNA which happens when the energy of radioactivity breaks the bases of hydrogen bridges in DNA. This study was conducted on 12 out of 29 cases of bladder cancer by using analyzed DNA sequencing. The result showed a mutation of the

in bladder cancer the tp53 will can become uncontrolled and multiply. This mutation in the bladder is different from another kinds of mutations such as the mutation found in lung cancer. The half-life of tp53 mutation is longer than normal tp53. In Iraq, the fourth most common form of cancer in men was bladder cancer and it was eighth most common in women. In the United States, about 45,000 men and 17,000 women are diagnosed with bladder cancer each year. Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Accounting for more than 90% of the cases is Transitional cell carcinoma. Researchers have found that about 37.9% of TP53 genes mutate, 58.6% of TP53 are over expressive, and 63.6% single mutations were observed [17] [18]. Another dangerous cancer is salivary gland cancer. The salivary consists of a major and minor gland. The location of the minor gland is throughout the nasal, palate, and oral