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Specifically, mutations in the gene that encode for the AIRE protein have been linked to type I autoimmune polyendocrinopathy (Shikama et al., 2009). Development of T-cells T-cells are a type of lymphocyte that play a major role in cell-mediated immunity and provide an immunological memory of previously encountered pathogens. T-cells arise from hematopoetic stem cells in the bone marrow and then go on to populate the thymus, which is why they are called T-cells. Thymocytes enter the thymus and begin to proliferate and generate a large population of T-cells. As they progress through development they go through positive selection in the cortex and negative selection in the medulla before reaching maturation and finally leaving to surrounding tissues.
A transposition- like mechanism can be used for other types of DNA rearrangement reactions. Such mechanism is responsible for assembly of gene fragments during development of the vertebrate immune system. Vertebrates have two specialized cells namely T- cells and B-cells that dedicated to recognize the invading organism. B cells produce antibodies that circulate in the bloodstream. T-cell produce cell surface- bound receptor protein called T-cell receptor.
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