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history of vaccinations
history of vaccinations
elimination of smallpox
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Smallpox is an infectious disease caused by the variola virus. Variola major and variola minor are the two clinical types of smallpox. Variola major is the most widespread and severe of the two. Smallpox is unique to human beings, and can be found worldwide. This disease is also known by the Latin name Variola or Variola vera, meaning spotted, or varus, meaning “pimple”. Europe came up with the name smallpox, and later in the 15th century used the name of this disease to distinguish between syphilis (Wikipedia, 2010).
Smallpox is transmitted through the air, and spread by direct contact with an infected person. This disease is very contagious, but does not spread quickly because of its short infectious period (Wikipedia, 2010). On a lesser scale transmission can be via contaminated bed linen or clothes. A person who contracts smallpox can remain healthy and noninfectious for up to 17 days. Flulike symptoms occur initially, then a rash appears first on the face then spreads to the extremities. Other symptoms include muscle pain, malaise, headache, nausea, vomiting, prostration, and back pain. Ulcerative lesions develop in the mouth and nose, and these lesions then discharge large amounts of the virus into the throat. Approximately one-third of people who contract this disease die, but those who survive smallpox were left blind with deep pitted marks mainly on the face (Levin, 2007).
Vaccination is the primary treatment for smallpox, and no medication is currently approved for treatment of this disease. Smallpox vaccination is needed within three days of exposure to prevent and decrease the severity of smallpox. Being vaccinated four to seven days after exposure will also modify the severity of the disease or may offer some d...
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...om a campaign against malaria gave WHO little reason to allocate funding to this program. Millions of people needed to be vaccinated and funds were not available. The eradication program was undermanned, and not until 1966 did more employees work full-time on the program (Levine, 2007).
The director-general told the World Health Assembly (WHA) that lack of funds for vehicles, supplies, and equipment made it hard for the eradication process to start. Political and financial support was distant. The World Health Organization had to depend on public campaigns which provided restricted leadership. This caused people to doubt if the eradication program was attainable, and also gave reason to deny funding and political support. All these factors played a role in WHO not immediately undertaking the eradication program after being endorsed by the WHA (Levine, 2007).
Throughout the eighteenth and nineteenth century a disease dominated the world killing one in three people who caught it, smallpox. The few that survived the disease were left with very disfigured bodies and weak immune systems. In modern days this disease seems very unusual and hard to catch; it is all because of one man, Edward Jenner.
The World Health Organization announced that smallpox had been eradicated from the planet on May 8, 1980. This was prompted by a three year absence of a smallpox infection; the last occurring case was reported in Somalia in 1977. Since then, worldwide stock of smallpox vaccines has been reduced enormously simply because of speculation that there is no need for it anymore and administering the vaccine is impertinent. After the disappearance of smallpox as an afflicting disease, it now exists in labs in only two locations, the United States and Russia, where it is studied for research purposes only. Smallpox is a virus that has two major forms, Variola major and Variola minor, and each form has similar and differentiating symptoms with regards to the other type (Alibek, 1999).
... risk of developing the disease. It was observed that those who had been infected with the clinically similar but less severe cowpox disease by milking cows were also immune to smallpox. This observation led Edward Jenner to his first ever vaccination technique. He inserted the cowpox virus obtained from the scabs of a woman into a boy, and then when the boy was inoculated some time later, he proved immune to smallpox (Fenner). It is impossible to contract smallpox from this inoculation of the less virulent related virus and allowed individuals a way to protect themselves without risk. Later, the smallpox vaccination was adapted by using a different live virus, the vaccinia virus which is more similar to variola than cowpox and therefore provides better cross-immunity. As the practice of vaccination gained popularity, it had a significant impact on life expectancy.
Smallpox did not play favorites when it came to choosing a victim. Whether it was a young child, or a older person, smallpox destroyed the lives of hundreds of thousands over a period of eight years in the colonies. Fenn did a great job in my opinion of describing just how bad this disease was and painted a horrific picture in explaining what people went through when dealing with the disease. Even as the author started her introduction into the book she explains that Viariola (smallpox) blinded, scarred, maimed and killed many of its victims. It is hard to even try and imagine what these individuals went through when dealing with smallpox. However, one thing is according the author they did not let the virus destroy them. They fought back with every fiber in their bodies to understand and illuminate this dreaded foe.
In order to understand the history of smallpox one first has to understand how diseases like it evolve. Much like other species, diseases that survive in the long run are the microbes that most effectively reproduce and are able to find suitable places to live. For a microbe to effectively reproduce, it must "be defined mathematically as the number of new infected per each original patient." This number will largely depend on how long each victim is able to spread the virus to other victims (Diamond, 198).
It was spread by physical contact with human skin and mostly affected children and adults. This disease was so outrageous that led to a vast number of deaths in New England colonies. Also, smallpox virus transmitted through airborne from the oral, nasal mucus of the infected person. But mostly was spread from close contact or contaminated material of the infected person. It was spread very slowly and less broadly than other viral illness which took long time to identify the infection in first two weeks. Infection of smallpox started to grow between 7 to 10 days when the scabs form onto bruise. The signs and symptoms of this disease were with high fever, widespread rashes, redness, muscle pain, headache, common cold, vomiting, nausea and many more. Consequently, the virus was found in the bone marrow along with bloodstream in huge numbers. There were different types in between the smallpox disease with other classification. By preserving the virus, Boylston personally inoculated 247 people in 1721 and 1722 to prevent transmission. However, from there only six people died, and Boylston was the first American surgeon to inoculate his patients personally. The author portrays the background data Boylston used to examine the inoculation practice on different age and gender of persons to cure his patients were from previous experiments. The inoculation method provided higher rank of immunity in preventing smallpox infection. The prevention for smallpox was through inducing antibodies by vaccine which lasts longer for a person taken
Henderson, Donald A., et al. “Smallpox as a Biological Weapon: Medical and Public Health Management.” Journal of the American Medical Association 281.22 (June 1999). 24 July 2008 .
...in tact by the 1900 34% of all children had been vaccinated. Britain soon discontinued the idea of the vaccination because there became less people who got infected with smallpox. It was a difficult process to take on the various act of vaccination because the increase of health measure to help control smallpox. By the 20th century a milder smallpox, called variola minor had enter in Britain but only causing about 1% of deaths. In 1973 there was said to be an out break from the laboratory killing two people. Soon the World Health Organization mount a campaign in 1967 when there was about 10-15 million cases yearly and to eradicate smallpox globally (Baxby, 1999). Smallpox was a way to be eliminated from the world and people who have been vaccinated and immune to the disease. The strategy to this method had eradicated smallpox causing the disease to be kept away.
...only likely occurrence), it can be concluded that the reappearance of the smallpox disease would cause devastation of great magnitude. Because of the eradication of smallpox so long ago, it is believed that any occurrence would be due to a bio-terror event (Centers of Disease Control and Prevention, 2009). The United State’s has a viable plan for response in the event of smallpox falling into the wrong hands and becoming weaponized. Hopefully worldwide endemics of the past would not reoccur.
In closing, the variola virus affected a great amount in that era including, military strategy, trade, and native populations. Elizabeth A. Fenn’s book Pox Americana: The Great Smallpox Epidemic of 1775-82 sheds light on a significant aspect of that era that had not been given proper credence beforehand. She also illuminated the effect of smallpox when it came to race and social status. With regard to race, smallpox decimated much of the non European populations partly because of their lack of an innate immunity to that virus and Europeans lack of regard for those of a different race. Fenn’s argument on social status showed how the poorer strata’s of society suffered more severely from the variola virus because of their lack of finances to get inoculated; thus, the poor often suffered a worse strain of the virus which often lead to death.
Lorion, D. (2006). Risk assessment for patients with Smallpox. Journal of Health Sciences, 108, 10, 812-826.
For approximately three-thousand years, smallpox has ravaged and plagued the four corners of the globe. In fact, in the 17 th and 18 th centuries, it was claimed to be the most infectious disease in the West, with an astounding 90% mortality rate in America. It wasn't until 1796, with English surgeon Edward Jenner's smallpox vaccination, that the world saw relief from this devastating virus. However, even with this inoculation in use, the world continued to witness death from both the virus and the vaccine. In the year 1966, it was estimated that 10-15 million infected citizens world wide had passed away from smallpox that year alone ( “History” 12). As a result of these devastating numbers, in the following year, 1967, the World Health Organization (W.H.O.) created a program to eradicate the smallpox virus. Ten years later, in 1977, the estimated 10-15 million cases had dwindled down to one; a man in Somalia. Three years later, W.H.O. officially announced that smallpox had been eradicated, leaving the only remaining virus cultures stored and guarded in laboratories in Russia and the United States. Inoculations ceased, smallpox epidemics were non-existent, and the virus was no longer a concern. In order to ensure complete eradication of this deadly virus, the W.H.O. insisted that the remaining smallpox cultures be destroyed by 1999 ( “Smallpox Eradication” 2). However, despite the W.H.O.'s recommendation, the remaining cultures continue to be contained and protected to this day, five years after the suggested date of elimination.
Smallpox had no particular age groups, it targeted the young old and middle aged, it also didn't matter if someone was rich or poor as even Abraham Lincoln contracted the disease and Joseph Stalin (Leader of the soviet union in the in the early 20th century) had got it at a young age. Smallpox also killed many native aboriginals when the First Fleet arrived in Australia nad brought the disease with them. To this day, people fear that U.S.A or Russia will use the Smallpox sample they have stored as a biological weapon, which could cause another outbreak in the targeted country. This would be horrific but vaccinations would be created to reduce the number of infections. There is also a very slim chance that it will be used as a weapon.
Smallpox is an very contagious disease that lasts for about 41 days, 24 of those days are mildly to severely contagious. Variola passes from person to person through contact, prolonged face to face contact, contact with body fluids or scabs from pustules, and in extreme cases the pathogen can become an airborne pathogen. The smallpox virus is passed from human to human and it is not known if any other animals and/or insects can directly pass the variola virus to humans. There have been many cases where people have confused the variola virus with other viruses. For example S Scar Rickettsiella is an deadly disease that is nearly identical to smallpox but it is not as deadly and somewhere on the body a little scar shaped like a S (about the size of an mole) appears on the body. There is one live culture of smallpox kept in America in Atlanta, Georgia in an very secure facility. There is also one kept in Novosibirsk, Russia. Many world leaders fear that the next weapon will be biochemical terrorism. Smallpox can become an airborne pathogen which could cause the greatest amount of damage in a terror attack. From the time the virus enters into...
...surrounded it due just to who was known to contract the disease first. The lack of prevention was then mostly due to the lack of information, and the neglect to the urgency of the disease by political leaders, as seen in Uganda by president Nelson. We could have saved millions of people lives had they known that the disease could affect anyone around them including themselves, and had they known what to do prevent the spread to them firstly, if not how to prevent transmitting it to someone else.