The Treatment of Microbial Infections Through New Antibiotics

2009 Words9 Pages
Human body hosts thousands of bacteria that play a major role in maintaining the health. At the same time, the body is fighting against thousands other microbes that may cause infections. Each year at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. Many more people die from other conditions that are complicated by an antibiotic-resistant infection consequently. Antibiotics may not vanquish the resistant pathogens and thus, there is a need for effective alternate strategies to treat microbial infections. Antibiotics have transformed medicine and saved countless lives over the past seven decades. Now, rampant overuse and the lack of new drugs in the pipeline threaten to undermine their effectiveness. There is a need to develop new antibiotics to supplement those that are losing their effectiveness. A number of phytochemicals are known to possess anti-microbial activity but due to their low stability, solubility and bioavailability, they are not used as medication in the present scenario.
In this project, we are focussing on the integration of conventional & present synthetic approaches for the development of an effective antibacterial framework for the treatment of microbial Infections.
We are trying to develop a delivery system that may encapsulate high dose of anti-bacterial phytochemicals and enhance its anti-microbial property.
Lipid based formulations like nanoemulsion and microemulsion are delivery systems that not only encapsulate high dose of phytochemicals, but also enhance the anti-microbial property of the phytochemicals encapsulated.
Furthermore, combining two compounds on a single nanoemulsion provides...

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...icro-organisms. They bind to lipid membrane of the microbe. This binding is thermodynamically driven process & leads to release of energy. This energy is enough to disrupt the microbial membrane leading to cell lysis & cell death[17].
When an antimicrobial moiety is encapsulated inside the emulsion, it not only acts as carrier or delivery system enhancing its solubility, stability and bioavailability but it also increases its efficacy. The Minimum Inhibitory Concentration (MIC) is reduced & the Zone of Inhibition (ZOI) expands leading to effective anti-microbial activity at lower concentrations of the antimicrobial moiety (Caffeine) being encapsulated. Therefore, the toxic effects of the drug/ compound can be reduced. For a compound like Caffeine which is neurotoxic, formulation of such carrier can be promising to fight against infections at reduced toxic effects.

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