According to Lu and Bludau, the brain is partitioned into four lobes: frontal, temporal, parietal, and occipital. The frontal lobe formulates major decisions, such as planning, thinking, problem solving, organizing, and executing movements. It is located at the front of the brain. The temporal lobe is positioned under the frontal and parietal lobe. It generates and stores memories. It also coordinates the senses of taste, sound, and smell. The location of the parietal lobe is behind the frontal lobe. Parietal lobe controls sensation and perception sensory information such as smell and touch. The occipital lobe is located at the back of the brain. Its primary function is vision.
The brain functions through a system of “chemical and electrical
…show more content…
The effect to the brain is at a cellular level. Amyloids plaques increase beta-amyloid, also known as protein fragments. Beta-amyloids “originate from amyloid precursor proteins (APP)” (Lu & Bludau, 2011). APP is large proteins associated with the cell membrane. They split into three enzymes. APP uses diverse conduit where the beta-amyloids are created. It then “deposits in the space between neurons and exert toxic effects” (Lu & Bludau, 2011). In certain areas of the brain, amyloids develop into additional abundant with Alzheimer’s. This damages neurons that “react with neuron receptors and axon” (Lu & Bludau, 2011), which impinge the cells ability to function. Neurofibrillary tangles are made up of tau proteins. It plays a major role with microtubules, which are shaped like stacks of straws. Microtubules transport important cellular components and nutrients. The tau proteins separate from microtubules and twist into tangles. When tau proteins become defective, microtubule disassemble and initiate the internal network to falter. Then neurons disable and cannot function normally. Over time, the influence of amyloid plaques and neurofibrillary tangles trigger the neurons to immobilize the ability to
Although the brain only weighs about three pounds, it is a very powerful and essential organ in the body (Brain Structures and Their Functions). The cerebrum, cerebellum, and the brain stem are the three main parts of the brain. The cerebrum fills up most of the skull, its main functions are for remembering, problem solving, thinking, and feeling (Bellamy 23). It also controls movement throughout the body. The cerebellum is located towards the back of the head. It controls mostly just coordination and balance (Brain Structures and Their Functions). The brain stem is underneath the cerebrum and in front of your cerebellum. It attaches the brain to the spinal cord and controls functions like breathing, digestion, heart rate and blood pressure (Carter 12). The brain is also divided into halves. The left side of the brain controls the right side of the body, while the right side of the brain, controls the left side of the body (Bellamy 17).
The brain has four major lobes. The frontal lobe, the parietal lobe, the occipital lobe, and temporal lobe are responsible for all of the activities of the body, from seeing, hearing, tasting, to touching, moving, and even memory. After many years of debating, scientist presents what they called the localization issue, Garret explains how Fritsch and Hitzig studied dog with conforming observations, but the cases of Phineas Gage’s accident in 1848 and Paul Broca’s autopsy of a man brain in 1861 really grabbed the attention of an enthusiastic scientific community (Garret 2015 p.6)
Nerve cell death and tissue throughout the brain is the most significant affect over time. Naturally by age twenty-five the brain starts to decrease in size. With Alzheimer’s, the amount decrease is extremely significant. The cortex begins to shrivel up which is the part of the brain required for planning, remembering, and thinking. The most noticeable shrinkage occurs in the hippocampus. The hippocampus is responsible for the formation of new memories, it is also located inside the cortex. Upon further inspection under microscope, tissue samples are observed and synapses and nerve cell count is severely decreased. Tangles, are also found which our twisted strands of another protein due to nerve cells dying and bunching together. Plaques and tangles are prime suspects in the death and tissue loss in the Alzheimer’s brain. Beta-amyloid is a chemical and is sticky which causes it to gradually build up into plaques. This chemical derives from a larger protein found in the nerve cells with fatty membranes. These tangles destroy a vital cell transport system made of proteins.
Alzheimer’s disease or AD is an incurable disorder of the brain that results in loss of normal brain structure and function. In an AD brain, normal brain tissue is slowly replaced by structures called plaques and neurofibrillary tangles. The plaques represent a naturally occurring sticky protein called beta amyloid and in an Alzheimer’s brain, sufferer’s tend to accumulate too much of this protein. Neurofibrillary tangles represent collapsed tau proteins which, in a normal brain along with microtubules, form a skeleton that maintains the shape of the nerve cells. In Alzheimer’s disease, the tau proteins break loose from their normal location and form tangles. Without the support of these molecules, nerve cells collapse and die. As normal brain structure is lost with progression of the disease, brain function also degenerates. Patients afflicted with Alzheimer’s disease display a gradual mental decline. Initially, and most apparently, there is a loss of short-term memory. Eventually, as a patient progresses to later stages of the disease, the brain becomes so damaged that patients can no longer communicate or recognize immediate family or even themselves. They have difficulty walking and standing and frequently fall. In the final stages, they lose bladder and bowel control and have difficulty with swallowing, frequently leaving them malnourished and dehydrated. Eventually, they are forced to remain bedridden and, without the help of life-prolonging measures provided in a hospital, die. However, this level of deterioration is severe and may take as long as twenty years. Because of the disease’s slow progress and its usual later start in a person’s life, a victim of AD will usually die first of natural causes. Under the objectives ...
Clinically, Alzheimer’s disease is characterized by the accumulation of beta-amyloid plaque between living neurons in the brain (Sabbagh, 2008). This results in an excessive calcium influx inside the neurons and the breakdown of a protein called tau. Normally, the rol...
There are three different abnormalities that can make up Alzheimer’s disease. The first abnormality is beta-amyloid peptide cut from APP, a membrane precursor protein (Marieb and Hoehn 2013). Too much beta-amyloid is toxic and causes plaque buildup between neurons that reduces levels of acetylcholine which makes is difficult to retrieve old memories and make new ones (Marieb and Hoehn 2013). Another abnormality of Alzheimer’s disease is the presence of neurofibrillary tangles inside the neuron. These tangles consist of tau, a protein that leaves its stabilizing role and binds to another tau molecule forming a neurofibrillary tangle. (Marieb and Hoehn 2013). Neurofibrillary tangles then kill the neuron. The final abnormality of Alzheimer’s disease is brain shrinkage. The brain shrink...
Alzheimer's disease is the source of the destruction or decline of brain cells or nerve cells. As a result of damaged nerve cells, the brain may have fewer bonds as compared to healthy brain cells. Amyloid plaques are outside the cell and are clusters of protein, Neurofibrillary tangles are proteins too, but they are inside the cell. It has not been confirmed on whether or not these protein clumps have any effect on Alzheimer’s or not, but they are ...
This disease causes memory loss, difficulty in thinking processes, mood swings, depression, hallucinations, personality changes, and the inability to create new memories. Alzheimer’s disease is most common in people who are at the age of sixty years or older, but it can start as early as the age of nineteen. It can be categorized as a type of dementia. “Scientists believe Alzheimer’s disease prevents parts of a cell’s factory from running well” (Alzheimer’s Disease: The basics). Scientist believe that one cause of Alzheimer’s could be caused by plaques and tangles. Plaques are the build up of a protein called beta-amyloid in the nerve cells. Tangles are twisted fibers of the tau protein that build up inside of a cell. The exact cause of Alzheimer’s has not yet been determined, but scientists have reason to believe that it is because these plaques and tangles are blocking the communication of cells in the nervous system. Another probable cause is a mutation on the chromosomal genes 21, 14, and 1. This is why it is believed to be a genetically inherited
Scientists know that Alzheimer disease is characterized by a gradual spread of sticky plaques and clumps of tangled fibers that disrupt the organization of nerve cells in the brain. However , a definite cause, prevention, or cause has not been found.
The frontal lobe comprises a third of the brain and it enables us to engage in higher cognitive functions such as planning and problem solving (Jonides & Smith, 1999). The frontal lobe is divided into 3 regions, the motor cortex, premotor cortex, and prefrontal cortex. The motor cortex is located in the precentral gyrus and directs fine motor coordination. The premotor cortex is involved in planning, organizing, and integrating body movements. The prefrontal is involved in executive functions, including short-term memory, working memory, decision making, and prioritizing behaviors (Wilson, 2003). Some of the frontal lobe disorders than can cause brain damage and behavioral changes are Huntington’s disease, infection, stroke, tourettes, dementia, epilepsy, Parkinson’s disease, tumors, closed head injury and traumatic brain injury (Chow, 2000).
Here the sensory data is stored and consists mainly of the senses found within the body which comprises of taste, touch, smell, temperature. Here these senses are integrated and processed before being transported to the necessary region to fulfil the response. If the parietal lobe was severed or damaged the human body would not be able to function properly as in the human body would not be to feel nor touch nor sense the feeling of being touch due the damaged that controls this motion in the parietal
Alzheimer’s Disease is named after a German doctor, who specializes in the brain and nervous system, named Alois Alzheimer. This Disease forms in the brain. Alzheimer’s is the most common form of Dementia, a general term for memory loss and other intellectual abilities serious enough to enter. The Tau protein ensures the tubes in your brain stay straight allowing molecules to pass through freely. In Alzheimer’s Disease the protein collapses into strands or tangles, making the tubes disintegrate. There is visible differences of brain tissue in the from misfolded proteins called plaques and tangles. Beta-Amyloid clumps block signals and communication between cells in the brain. Researchers agree that Alzheimer’s Disease is m...
This lobe is also located in the cerebral hemisphere. The parietal lobe is focused on comprehension, language, reading. It also monitors all sensory comprehension. The pariental lobe has two parts. The sensory cortex and motor cortex. The sensory cortex, is located in the front part of the parietal lobe, it recieves information from the spinal cord about the different positions of various parts and how they move. This area of the brain affects area 's like sense of touch and relays if there is pain or pressure to different parts of the body. The motor cortex 's main function is to monitor and control movement of the body. It is located in the top, middle portion of the
The area at the front of the brain is the largest. Most of it is known as the cerebrum. It controls all of the movements that you have to think about, thought and memory.
The left and right hemispheres of the brain are each divided into sections. Within each sections are lobes, controlling such processes as our visualization, our movement, and our personalities. For instance, the occipital lobe in the back of our brain is responsible for processing vision, and the frontal lobe behind our forehead controls cognition and personality. The lobes of the brain are split between the right and left hemispheres of the brain. This well-designed arrangement is for the lobes to function correctly, so the two hemispheres of the brain can communicate with one