Regulation of Metabolism
The gut microbiota obtains its nutrients from various sources such as consumed dietary ingredients and host-derived requirements like epithelial cells and mucus. Microorganisms utilize these substrates to produce energy to modulate cellular processes, metabolism and growth. The gut encompasses pathways for carbohydrate, lipid and amino acid metabolism (6). Interestingly, the gut flora’s metabolic action is both adaptive and renewable. Through the synthesis of short-chain fatty acids (SCFAs), B vitamins and vitamin K, commensal bacteria mutualistically interact with intestinal epithelial cells to promote differentiation, proliferation and absorption from the bowel. Jointly, this metabolic mechanism preserves valuable energy and digestible substrates for the host, all while supplying energy and nutrients for growth (9). SCFAs (mainly acetate, butyrate and propionate) are the final products of the carbohydrate fermentation of dietary fibers, and exhibit many positive influences in countering metabolic and inflammatory disorders, for instance, obesity, diabetes, and inflammatory bowel disease. This is accomplished via the activation of G-protein-coupled receptors and alteration of transcription factors (17, 18). The microbial assembly of SCFAs, TMA, acetaldehyde and inflammatory regulators control the metabolic fitness of the host through pathways that affect gut motility, immune function and satiety (19). An example of a lipid metabolic activity that relates the gut flora to dyslipidemia (excessive amount of lipids) is the hydrolysation of bile salts, which are steroid acids manufactured in the liver from cholesterol and secreted in bile to accelerate absorption of fat-soluble vitamins, along with the metabol...
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...ience, 336, 1262-1267.
21. Ramakrishna, B. S. (2013). Role of the gut microbiota in human nutrition and metabolism. Journal of Gastroenterology and Hepatology, 28(S4), 9-17.
22. Cani, P. D., Everard, A., & Duparc, T. (2013). Gut microbiota, enteroendocrine functions and metabolism. Current Opinion in Pharmacology, 13(6), 935-940.
23. Xie, G., Zhang, S., Zheng, X., & Jia, W. (2013). Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes. Electrophoresis, 34(19), 2787-2798.
24. Chassard, C., & Lacroix, C. (2013). Carbohydrates and the human gut microbiota. Current Opinion in Clinical Nutrition and Metabolic Care, 16(4), 453-460.
25. Aziz, Q. Q., Doré, J. J., Emmanuel, A. A., et al. (2013). Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterology & Motility, 25(1), 4-15.
Jennifer Ackerman's main focus in her article The Ultimate Social Network, is that of the functions concerning bacteria within humans. Although scientists have had presumptions about humans being proficient in governing their body’s innermost structure, they soon come to recognize the sophistication of our inner space which holds an extensive plethora of bacteria and other microorganisms that lie within each and every one of us. Moreover, scientists' new and emerging view of how the human body operates, and the cause of increasing present-day diseases (i.e. obesity and different autoimmune disorders) are uncovered by analyzing effects of certain microbe species in our bodies. By italicizing on points such as the above, in conjunction with bacteria's genetic variations, and modern computing technology, the author proves that scientists are quickly progressing with the characterization the most prevalent species of microbes, which, in her opinion, is definitely paying off.
According to the article The mechanism and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhea there is a great concern about increasing incidence of C. difficile infection due to use of broad spectrum antibiotics. Clindamycin, third generation of cephalosporins and flouroquinolones are considered high risk antibiotics. It is believed that normal gastrointestinal flora has potential effect in inhibition C.difficile growth and toxin A,B release which offen associated with sever diarrhea resulting in patient’s mortality and other comorbidities. After first episode, there is a high chance for relapses due to reduction serum IgG antibodies to toxin A and colonic IgA secretion cells.
Although I have never been someone who has taken an interest in reading about nutrition and how it affects our bodies, I really enjoyed the book, Eat Dirt by Josh Axe. The author discusses how he took an interest into leaky gut after his mother was diagnosed with cancer a second time and he created a plan to help her eat healthier in order to improve her health. The plan worked wonders for his mother, although he claims the plan won’t cure her or anyone else in her case it was highly effective. Throughout the book, Axe continues to provide the reader with examples of what his patients have suffered from and how, through changing their eating habits, have improved their lives significantly. After each example of patients, the author informs the reader of what leads to leaky gut and ways to combat it. Each chapter expands on the five ways to combat leaky gut by providing examples on the topics such as, what to eat and what probiotics to take for certain conditions. Throughout his
Lipid metabolism is one source of energy for the human body. We eat food containing one form of lipids, triacylglycerols. Before starting lipid metyabolism, these fats get broken down into droplets by bile salts.Triacylglycerols can be broken into fatty acids plus glycerol via hydrolysis with the help of the pancreatic lipase enzymen and then get used by cells for energy by breaking down even further. Once the pancreas and cells have enough energy and don’t need to absorb anymore, fatty acids get synthesized back into triacylgleryols. The excess triacylglycerols get stored in adipose tissue. Excess storage leads to weight gain and obesity.
Through time, most renowned practitioners of alternative medicine have claimed that an unclean colon is the most dominant cause of all kinds of diseases. Without regular and proper bowl movements, the waste material that is supposed to be driven out of the body remains inside. They in turn produce toxins which are slowly absorbed by other parts of the body including the organs. This in no way can be something good for the body. In fact the toxic waste can
Every human has microbiomes that are personalized for the individual and are extremely important to maintaining a good health standing, however, these microbiomes can be capable of contracting a disease. One of the most common areas for these microbiomes to contract something that could be harmful to the person’s health is called the oral microbiomes, which are found in the mouths of humans. Within the biofilms of the oral cavity, rests these oral microbiomes that maintain a healthy equilibrium in the mouth. However, if not taken care of properly, oral microbiomes can be taken over by a pathogen that can quickly turn the state of the person’s mouth from a healthy equilibrium to a very unhealthy equilibrium (1). Some bacteria found in the oral cavity can be an extremely danger.
Diabetes is a metabolic disease, that causes a person to have high blood pressure. There are two kinds of diabetes, type 1 and type 2. Type 1 is the loss of insulin producing cells, leading to a deficiency of insulin. Type 2 diabetes is where the person is insulin resistant. Insulin is a peptide hormone, which causes cells to absorb the various glucose it requires. Type 2 diabetes is the most widespread endocrine disease worldwide. Metagenome wide associated study took on a study that was based on the determination of type 2 diabetes and relationship to gut microbial by using the deep shot gun sequencing of the gut microbial. The study consisted of 345 Chinese's individuals that were used to help find any relationships. 60000 type 2 diabetes associated markers were used and linked to type 2 diabetes. Gut microbes are living organisms that live in the gut and the digestive tract. Patients with type 2 diabetes were characterized by a moderate degree of gut microbial symbiosis. Symbiosis is a interaction between different microbial organisms, there are various types of symbiosis such as mutalistic, parasitic and communalistic. The abundance of butyrate producing bacteria as well as the opportunistic pathogens were determined as well. Enrichment of microbial functions due to sulphate reduction and oxidative stress resistance was found. Further studies were also performed with addition of individuals to the study. Gut microbial markers may be useful for classifying type 2 diabetes.
6. S. Yoshimoto, T. Loo, K. Atarashi, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome, Nature, 499: 97-101, 2013.
In order to test the effects a pure Soylent diet has on gut microbiome diversity, 125 college students will be recruited and given either a control or Soylent diet. Students will submit a stool sample to record their initial gut microbiome diversity (Gordon et al. 2006). This initial test will be used to divide the students into two different groups, low initial gut microbiome diversity and high initial gut microbiome diversity. The low initial gut microbiome diversity group is defined as having 11 or fewer predominant species of bacteria in their gut, while the high initial microbiome diversity group is defined as having 16 or more predominant species of bacteria present in their gut (Crittenden et al. 2002). Individuals who have between
Among hospitalized patients around the world, Clostridium difficile is the primary source of infectious diarrhea. Previously, continuously unbalanced intestinal microbiota, usually due to antimicrobials, was deemed a precondition of developing the infection. However, recently, there have been alterations in the biology from virtually infecting the elderly population exclusively, wherein the microbiota in their guts have been interrupted by antimicrobials, to currently infecting individuals within of all age groups displaying no recent antimicrobial use. Furthermore, recent reports have confirmed critical occurrences among groups previously assumed to be of minimal risk—pregnant women, children, and individuals with no previous exposure to antimicrobials, for instance. Unfortunately, this Gram-positive, toxin-producing anaerobic bacterium is estimated to cost US critical care facilities $800 million per year at present, suggesting the need for effective measures to eliminate this nosocomial infection (Yakob, Riley, Paterson, & Clements, 2013).
MacLennan R, Zhang A. “Cuisine: the concept and its health and nutrition implications-global.”Asia Pacific J Clin Nutr. 13.2(2004):131-135. Print.
Microbes are everywhere in the biosphere, and their presence invariably affects the environment in which they grow. The effects
... Dietetic Association. Journal of the American Dietetic Association 95.10 (1995): 1160. ProQuest. Web. 3 Dec. 2013.
People is always asking: “Why is important to have a balanced diet? Why is necessary to have a balanced diet on a daily basis? And why do professionals tend to recommend a balanced diet?” The human being has essential needs to its existence: breathing, feeding, and keeping the body in constant movement. The majority of the people are aware of this, but they do not have a balance among these things and even more important they do not eat the adequate food to keep their body healthy. Food is one of the most important factors because it gives the energy the body needs daily. In other words, few words food is the fuel that provides glucose, which is carried to each cell of the body through the bloodstream. This process is extremely important and this is influenced by the type of food that each person consumes. A balanced diet is important for human beings, and makes reference to a good nutrition with regard to the food they eat; which contains macro nutrients that are carbohydrates, fats, and proteins; these provide energy and basic materials that the body uses to grow and stay healthy.
Microbes are major key components in both are homes and industrial food preparation. There are number of lactic acid which is a form of bacteria which is a large group of beneficial bacteria used in certain foods while they are getting prepared such as yogurt, cheese, sour cream, butter milk and other type of fermented milk products. Things such as vinegars are produced by bacterial acetic acid fermentation. Yeast is also major use in the making of beer and wine and also for the leaving of breads. This also involves fermentations to convert corn and other vegetable carbohydrates to also make beer, wine or gasohol but also bacteria is the agents of are other foods. Other fermented foods will include things such as soy sauce, olives and cocoa. (Microbes and human life, 2013) Single cell proteins are known as dried cells of microbes which are used in protein supplement shacks. They are also called “novel food” and “minifood”. The production of this requires micro-organisms which then serve as the protein source and then the substrate which is biomass which they grow on them. There are a number of both these sources that we are able to use for the production of single cell protein (SCP). The micro-organisms used belong to the following groups of Algae, Fungi and bacteria. (Slide Share, 2012)