The Publication of the HeLa Cell Genome: Henrietta Lacks and Cervical Cancer

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Henrietta Lacks, better known as HeLa to scientists around the world, is an African-American woman who unknowingly changed the course of medicine and science. On February 5, 1951, Dr. Howard Jones of Johns Hopkins Hospital, diagnosed Henrietta with cervical cancer. A few days later on February 8, 1951, Henrietta underwent her first radiation treatment for the cervical cancer. The doctors, without Henrietta's permission, took two samples from her cervix: one from the tumor, and one from the healthy cervical tissue. These samples were given to Dr. George Otto Gey, the head of tissue culture research at Johns Hopkins, who cultured them into immortal line of HeLa cells. The HeLa cells have been instrumental in all sorts of research, such as developing the polio vaccine, studying the effects of radiation, and testing the safety of pharmaceuticals. In 2013, the genome of the HeLa cell was sequenced. The sequencing of the HeLa cells led to ethical concerns from the scientific community, but it also did lead to new discoveries, such as why Henrietta Lack's cancer was so aggressive and why the HeLa cell is an immortal cell line.
The publication of the HeLa cell genome sparked outrage through the scientific community, due to the fact that the Lacks family were not notified prior to the publication. They had no idea that Henrietta's genome had been sequenced and was about to be published for the general public to view. Genome of family members are similar, so if Henrietta's genome was up for the public to see, then so would the genome of the Lacks family. People around the world would then know private information about the Lacks family, such as if they are predispositioned towards having high blood pressure or breast cancer. After the Lac...

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...7 genes were expressed at a higher rate in HeLa cells than in any of the human tissues (Landry et al. 2013). Many of those genes were related to functions such as proliferation, transcription, and DNA repair, which if expressed at a high level, would cause the cells to reproduce so quickly and accurately that the line becomes immortal. Immortality is the main trait that allowed the HeLa cells to become famous, because they were the only sample of cells that Gey was able to culture.
Henrietta Lack's cells has changed the course of medical research around the world. They have been a crucial part of many medical breakthroughs, and they also have caused us to critically think about the ethics of medical research. Even though there are now quite a few immortal cell lines, HeLa cells will remain to be one of the most widely used and most influential cell lines in history.

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