Introduction
Hepatitis B, an infectious disease caused by the Hepatitis B virus (HBV, a DNA virus), was formerly called serum hepatitis, inoculation hepatitis and post-transfusion hepatitis. Infection with HBV may result in acute, fulminant or chronic hepatitis, sometimes even resulting in a chronic asymptomatic carrier state, apart from hepatocellular carcinoma and liver cirrhosis (Davis 179). The disease is transmitted when an individual comes in contact with infected blood or objects. It may also be transferred from an infected mother to her infant either during or after birth (Zuckerman et al. 211). Transmission may also occur by accidental inoculation from infected needles and hospital equipment, intravenous drug abuse, body piercing, tattooing, and mouth-mouth kissing (Zuckerman et al. 210). The risk of Hepatitis B is particularly high in individuals with multiple sex partners, and in homosexuals. The HBV virus occurs in morphologically different forms in the serum of infected individuals. HBV infection has an incubation period of about 75 days. Systemic symptoms of the disease include fatigue, fever, dyspepsia, arthralgia, malaise, and rash, while local symptoms include hepatomegaly, jaundice, dark urine, and pale stools (Davis 179; Zuckerman et al. 210).
Anatomical/physiological/biochemical changes that lead to the disease
Hepatitis B results from cellular injury to the liver, subsequently affecting its metabolic functions. However, the HBV is not cytopathic by itself. The pathogenesis of Hepatitis B occurs as a result of the interactions between the host’s immune system and the virus. The host immune system targets HBV in liver cells (hepatocytes), inadvertently causing damage to the liver. HBV derived proteins (...
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...BeAg), bilirubin level, and platelet count (Pyrsopoulos and Reddy). The disease prognosis can be done by calculating the prognostic index based on the status of these six variables.
Conclusion
HBV infection is complex and affects a large population worldwide. The discovery of the Australia antigen (HBsAg) in 1965 by Blumberg et al. (1965) set the stage for rapid progress in understanding and counteracting the disease (qtd in Zuckerman et al. 210). Liver function tests help in estimating the extent of damage caused to the liver during HBV infection. Diagnosis is done by detecting viral specific antigens in the serum. Both active and passive immunization options exist for disease prophylaxis. However, it is always best to practice caution over the parenteral, sexual and other routes of transmission of the disease for effective disease prevention and prophylaxis.
“Improved sanitation, food safety and immunization are the most effective ways to combat hepatitis A.” (World Health Organization, 2017) Good hand hygiene is essential in preventing the spread of Hepatitis A. Proper sewage disposal systems are also important in prevention of Hepatitis A within communities. If a person is traveling to an area where hepatitis A is prevalent, they should avoid ingesting water and uncooked fruits and vegetables. Another important way to prevent Hepatitis A is immunization. A vaccine for Hepatitis A has been available in the US since 1996. Commonly children will become immunized between the age of 12 to 23 months, however an adult can also be vaccinated at any time. Traveling out of the country, using illegal drugs, homosexual men, and anyone who comes in contact with an infected person or animal are recommended to be immunized. The final way Hepatitis A can be prevented is with immune globulin. Blood from an already immune person will be injected into another person giving the recipient protective antibodies. Immune globulin will protect a person from exposure to Hepatitis A for 2 weeks. (Center for Disease Control,
We need to understand the structure of the virus, the viral genome, and how it causes the disease, and also to better understand the body’s immune response to the infection. Hepatitis B is a hepadnavirus, (slectron emicroscopy image), with a 42 nm virion. The virion is a double shelled spherical particle and consists of smaller rods and spheres each with an average 22 nm diameter. Not surprisingly the virus is very resistant and survives in high temperatures and is known to have been sequenced from 400 year old mummified
The Hepatitis B virus is a disease that affects the liver and results in swelling and loss of normal function in the liver. It is estimated that 350 million people are infected with Hepatitis B worldwide, with 50 million new cases diagnosed every year.(1) In the Unit...
Hepatitis A is caused by the Hepatitis A virus (HAV). (Kahn & Higuera, 2017) Consumption of faecal matter, even in minute quantities, Close contact with an infected individual, sexual intercourse with an infected person, and consumption of contaminated food or drink. (Prevention, 2017) Hepatitis B is commonly contracted through contact with infected blood, semen or any form of contact with any form of bodily fluid which is transmitted through sexual intercourse, needle sharing or the sharing of any injection instrument or during childbirth, in this case, transmitted from infected mother to her baby. (“Hepatitis | NIH: National Institute of Allergy and Infectious Diseases,” 2015) The transmission of hepatitis C is caused by the hepatitis C virus (HCV). It is transmitted through direct
Hepatitis B Virus (HBV) is a virus that leads to infection of the liver. Infection of the HBV can be acute or lifelong (chronic). Humans are the only known host for HBV (CSC, 2017). This virus can survive on environmental surfaces for up to seven days (WHO, 2017).
Hepatitis B Virus (HBV) is a virus that attacks the liver. The virus is transmitted through blood and bodily fluids. This can occur through direct blood-to-blood contact, unprotected sex, use of contaminated needles, and from an effected mother to her newborn during the delivery process. The majority of people do not have noticeable symptoms when they are first infected with the HBV. People who do not know they are infected with the HBV, their body can respond in different ways. I learned that some of the common symptoms of Hepatitis B infection include fever, fatigue, muscle or joint pain, loss of appetite, mild nausea, vomiting, and dark-colored urine. Some of the serious symptoms that require immediate medical attention and maybe even hospitalization are: severe nausea and vomiting, yellow eyes and skin (jaundice), bloated or swollen stomach.
As chronic viral hepatitis has a high prevalence in patients with HIV, clinicians should assess the risk of development of hepatotoxicity in these patients whenever HAART is initiated.7
Hepatitis B virus (HBV) is a severe and common virus that has infected ‘more than two billion people alive today at some point in their life.’1 It is a hepadanavirus that interferes with the liver functions as it replicates in the hepatocytes (liver cells) and induces a immune response that is responsible for the inflammation of liver.2 Viruses are not motile, which means that HBV is also sessile and does not form spores. The spherical virion, is called a Dane Particle3 that is 42nm in diameter binds to the surface of hepatocyte.1 The virion itself contains an inner protein core, 27nm thick filled with circular partially double stranded DNA, DNA polymerase and reverse transcriptase.1 It is an enveloped virus, so it also holds an outer lipoprotein envelope4 that is 7nm thick and is comprised of many embedded surface proteins such as surface antigen for viral binding and entry.1 HBV has an average incubation period of three months, which means that it does not start showing symptoms for the first three months that the person is infected and that person can unknowingly infect others.2 ...
There are four phases of Hepatitis B: infection, inflammation, fibrosis, and cirrhosis. In the first phase, HBV invades the liver and goes for the nucleus, where it releases contents of DNA and polymerase into the surroundings. It then maneuvers its way to the cell’s components and enzymes. The polymerase sways the liver cells to make segments of the HBV DNA from RNA. The virus makes liver cells create spare parts for other HBV viruses. Replicas are released from liver cell into the bloodstream, destroying host cell and infecting other healthy liver cells. This entire process can take a few hours to occur, but must continue multiple times for serious damage to occur. The second phase is inflammation. Inflammation is caused by lymphocytes trying to get rid of the virus, but they also release harmful chemicals that damage the cells and take part in damaging the liver. The third phase is fibrosis. Fibrosis is scar tissue caused by inflammation and chronic infection. According to Everson and Weinburg, (2002, pg. 64) “Only 5/10% of people develop chronic Hepatitis B from acute Hepa...
The signs and symptoms of blood borne pathogens vary based on the type of disease it is and the ability of a person’s immune system to fight it off. In most cases hepatitis B does not need to be treated and the body can fight it off on its own. However a long-term infection can develop in some people that can cause liver damage. There is a vaccination available to prevent acquiring the disease. The signs and symptoms for hepatitis C are usually mild. It can take two weeks to six months after contact before signs begin to show, or there may not be any symptoms at all. Hepatitis C typically becomes is a long-term infection and after many years will cause liver ...
Hepatitis B (HBV) is a blood-borne viral liver infection with various routs of transmission. It is one of the most common and serious liver diseases in the world and a leading cause of death worldwide. If the infection becomes chronic the infection can lead to liver failure, cirrhosis and hepatocellular carcinoma.
“Hepatitis is an inflammation of the liver.”("What Is Hepatitis?") There are three main types of hepatitis. These include hepatitis A, B, and C. These three types of hepatitis cause the most concern to medical staff due to their ability to spread and cause outbreaks. “Hepatitis A is a contagious liver disease that results from infection with the Hepatitis A virus.” (Centers for Disease Control and Prevention) It can range from acute to chronic. An individual can become infected with hepatitis A if they eat or drink food or water that has been contaminated with the virus. Some common “sources of vitamin A include shellfish, fruits, vegetables, ice and water”. (U.S. National Library of Medicine. “Hepatitis A.”) Hepatitis B is a serious, endemic, worldwide disease that can occur at any age. (Wilkins 45) The hepatitis B virus causes hepatitis B infection. Hepatitis B is transmitted though contact with the blood or bodily fluids of an infected person. (U.S. National Library of Medicine. “Hepatitis B.”) Hepatitis C...
“This knowledge will help us design drugs that mimic the viral effects on these proteins to either activate a host’s immune response or shut it down,” said Dr. Michael Gale, associate ...
Hepatitis B was the first of the hepatitis viruses to be discovered. There are seven genotypes for hepatitis B (Zein & Edwards, 2009). There are two forms of the disease, acute and chronic. Acute hepatitis B is a form which lasts less than six months, whereas chronic hepatitis B lasts from six months on. Symptoms of acute hepatitis B include: fever, abdominal upset, nausea, decreased appetite, vomiting, and changes in the way things taste or smell (Zein & Edwards, 2009). Some individuals infected with acute hepatitis B display symptoms, while others show no symptoms. Acute hepatitis B often goes undetected as a result.