From prehistoric period to the present time, plants and animals have been modified by breeding and natural selection. In the beginning of the human civilizations, human beings unconsciously started to create new forms of living beings denominated “hybrids”, crossing different individuals and species during the domestication process. According to Root (2007), an important example of domestication process can be illustrated by the dogs that arose from the wolf circa the 12,000. The canines, in general, were probably used as a helper during the hunting in the Neolithic communities. Several lineages of organisms were created during the process of characteristic selection and a considerable practical knowledge was developed by breeders over the centuries. However, in the view of Hartl and Orel (1992), until the 1800’s, most of the process involving modification of living beings remained empirical, in other words, the variations were made by chance using crossings between individuals. At this point, two historical facts during the development of the genetic knowledge should be emphasized: the publication of The Origin of Species in 1859 by Charles Darwin, and the advent of genetics with the work of the Augustinian monk, Gregor Mendel, in 1865. …show more content…
The real applications for the society were initially seen in 1990, when the gene therapy trials on humans started for the treatment of incurable diseases. At this time, Scotland scientists announced the birth of a lamb (Dolly) cloned by nuclear transfer using a mammary cell from an adult sheep. This achievement shows that the humanity were able to clone a complex organism in the lab for the first time. Following this realization, several mammals were cloned and the many human genes were transferred to rats, monkeys and dogs creating the humanized animals. This kind of animals can be used in medical research with a model to study human diseases, for
It was in the 1980’s that scientist began looking at alternative ways of treatments, one is gene therapy. Scientist would insert human genes into a bacteria cell. Then the bacteria cell would transcribe and translate the information into a protein. Once that is done the scientist would then introduce the protein into human cells. Gene therapy can be simply viewed as inserting bits of foreign DNA into a patient’s tissue in hope...
In 1859, Charles Darwin, a geologist published ‘The Origin of species.’ This book was published in a society where the idea of a descent with change or evolution was not a controversial topic. Darwin used the data from his experiments on nature to convince everybody that his theory of Natural selection was correct.
Gene therapy, a relatively new innovention, is becoming popular across the country. Gene therapy modifies a part of an organism, whereas cloning creates an entirely recreated organism. This technique can be conducted in vivo in either somatic or germ cells. The process is essentially aimed at fixing a genetic disorder or disease by inserting a functional gene to replace the faulty one (Houdebine 2003). Many methods to conduct a gene transfer have been tested. The two types are in vivo and in vitro. Transferring genes in vivo means placing the functional genes directly into the target tissue; while vitro transfers creates the genes outside of the body, in Petri dishes. Vitro is an expensive process that r...
Throughout the world there are many different countries that contain diverse cultures, religions, and life styles. There is however certain aspects within these countries and cultures that acts as a common ground between one another. One dominant aspect is the existence of dogs within these cultures. Dogs are common throughout the world, either as a domestic pet, a protector on a farm, or an assistant for hunting; amongst others. Regardless of the reason for having a dog most people have either owned one for themselves or has known somebody who has owned one at some point in their life. Despite the relative normality of having a dog in your life in one way or another, the reasons for dogs coming into existence is not common knowledge among most people. Throughout a great portion of mankind’s history dogs have been an essential part of life. The truth is dogs were actually created in part by man. It was evolution from wolves in the form of natural and artificial selection that brought dogs into existence (Harris 3). This is the most modern and widely excepted theory at this time, however this was not always the case considering the theory of evolution in of itself is relatively new in our society. After evolution as a theory was accepted there were several other variations on the theory such as, the evolution being from jackals opposed to wolves, and artificial selection being the only form of evolution to have taken place. According to Jarret A Lobell and Eric A Powell of Archaeology magazine “The idea that dogs were domesticated from jackals was long ago discarded in favor of the notion that dogs descend from the gray wolf (2)”. As for the theory that artificial selection ...
Cloning is a recent innovative technique the National Institute of Health defines as a process employed to produce genetically identical copies of a biological entity. Depending on the purpose for the clone, human health or even human life can be improved or designed respectively. “Somatic cell nuclear transfer (SCNT) is the most common cloning technique. SCNT involves putting the nucleus of a body cell into an egg from which the nucleus has been removed."^1 From this technique, an embryonic cell is activated to produce an animal that is genetically identical to the donor. Today, human cloning still remains as a vision, but because of the success of Dolly, the lamb, researchers are becoming more confident in the ability to produce a genuine
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
“The bill would ban human cloning, and any attempts at human cloning, for both reproductive purposes and medical research. Also forbidden is the importing of cloned embryos or products made from them”; these are the views of a US representative, Ken Calvert. Humans have been cloning plants and small animals like invertebrates since centuries but the idea of human cloning is controversial and a topic of discourse. Human Cloning refers to the asexual production of a human being from an ancestor to which it would be genetically identical. Scientists started their research on cloning animals in 18th century. August Weismann, In 1880s, proposed that the genetic information of a cell would diminish with every cell division. Hans Spemann challenged his idea and in his book entitled “Embryonic Development and Induction” talked about a fantastical cloning experiment which later became a basis for animal cloning. He called it a “nuclear transfer experiment” and suggested that cloning could be carried out by transferring nucleus from a cell into an enucleated – a cell whose nucleus has been removed – egg. John Gurdon, at Oxford University, put forward his idea and cloned South African frogs from an intact nucleus of a Xenopus tadpole. After Gurdon, an English embryologist, Dr. Ian Wilmut started research on cloning of mammals and cloned a sheep named “Dolly” which became an important scientific and technological breakthrough. With the birth of Dolly, the world realized that animal cloning was no longer a dream or an element of a science fiction movie and the debate about human cloning captured much attention.
Ever since the successful birth of Dolly on July 5, 1996, the scientific community as well as the public have been engulfed in the idea of reproductive cloning, its benefits, and its potential threats. This well-publicized event was a giant steppingstone in understanding and using the techniques of gene cloning and reproductive cloning. By using a technique known as Somatic Cell Nuclear Transfer, scientists at the Roslin Institute removed the nucleus from an oocyte (unfertilized egg), and then fused this newly enucleated cell with a donor cell (with complete nucleus). This new embryo was then implanted into the womb of a surrogate mother ewe. In total, out of 277 fused cells, 29 successfully developed into embryos, while only one of these resulted in a successful live birth (a total success rate of 0.4%) (Wong, 202). Dolly was the first living mammal to be cloned by this fast and accurate process of somatic cell nuclear transfer, but was by no means the first animal to be cloned. The first...
When Mendel’s research was rediscovered in the early 20th century, many geneticists believed that his laws of inheritance conflicted with Darwin’s theory of natural selection.
In the early 1840s, the main principles of Darwin’s theory of evolution were formulated by the mechanism of natural selection; however, he did not publish it. Although evolutionary theory sprouted in many places, Darwin rejected the publication of his theory, and it was not until 1859 that he published “On the Origin of Species” (Darwin, 1859).
Every year, the rate of mortality increasing because most diseases may lead to death if not treated early. One of the methods that can be used to cure some diseases is by using the treatment known as gene therapy. Based on Pruitt’s (2008) study, numbers of inherited and acquired diseases were reduced since gene therapy has the ability to provide new treatments to cure them. According to Shi and Zou (2008), gene therapy is defined as expression of protein or interrupts the synthesis of protein in cell by transferring the genetic material into a host in order to treat or prevent a disease. Besides that, Kelly (2007) stated that an “abnormal” hereditary disease-causing gene in an individual’s cells and tissues is treated and used gene therapy by to replace them with a “normal” gene. Around 1970’s, idea to use “genes” as “drugs” for human therapy was originally from United States (Giacca, 2010). Moreover, there are some objectives in using the gene therapy as a treatment. First, gene therapy is used to cure or slow the progression of disease by introducing the genetic material into target cells and next objective is to aim at the direct correction of endogenous genetic defects by delivered some additional copies of a gene (Pruitt, 2008; Giacca, 2010). Furthermore, Yadav and Tyagi (2008) found that there are two types of gene therapy which are germline gene therapy and somatic cell therapy. As stated by Shi and Zou (2008), therapy that involved modification of any cells in a patient’s body is called as somatic cell gene therapy while germ line gene therapy is therapy that involved modifying of human eggs or sperms that pass genes on to future generations. Other than that, animal tissue culture is used to test the effective...
The transition to the diet of the original dog as a result of beginning the relationship with humans could be attributed to the changes identified between the modern dog and original dog (wolf). The canids remain recovered in yet cave, in Belgium where Upper Paleolithic artifacts were discovered along with other object are considered to be domesticated dogs. The domestication of dog could have been driven by human need for help with herding, hunting, and early warning while the dog benefited from companionship and reliable source of food
Anyone with even a moderate background in science has heard of Charles Darwin and his theory of evolution. Since the publishing of his book On the Origin of Species by Means of Natural Selection in 1859, Darwin’s ideas have been debated by everyone from scientists to theologians to ordinary lay-people. Today, though there is still severe opposition, evolution is regarded as fact by most of the scientific community and Darwin’s book remains one of the most influential ever written.
It is difficult to dispute the fact that the successful cloning of Dolly has far-reaching applications in the twin fields of biotechnology and bioengineering. The advanced genetic reprogramming techniques employed to fashion the clone have opened the door to a multitude of potential avenues for application: genetic engineering of organs for transplant purposes, xenotransplantation, cell therapy for illnesses such as Leukaemia, Parkinson's disease and diabetes, "therapeutic cloning" (the notion of growing tissue for patients that is genetically identical to their own, for example neural cells could be made for people with Parkinson's disease, new muscle for those with ailing hearts and, later, perhaps even whole organs might be grown, all free from the threat of tissue rejection), and even in curtailing the extinction of endangered animal species, just to name a few.
Human genetic engineering has the capability to transmit usually fatal diseases. Although transmission is highly unlikely, it is one of the risk factors scientists have taken into great consideration. If animal cells or organs are transplanted into humans, zoonotic diseases may be spread. Bovine Spongiform Encephalopathy, Porcine Endogenous Retroviruses, and Nipah Encephalitis are all potentially fatal zoonotic diseases that could be transferred (Glenn). According to Linda MacDonald Glenn, J.D., L.L.M., “The introduction of these diseases to the human population could have devastating consequences” (Glenn). Human genetic engineering may also cause the production of unwanted mutations such as developmental issues. The procedures that would be used for genetically modifying human cells would include numerous alterations to sperm, eggs, stem cells, or embryos before entering a woman’s uterus. This could potentially modify the growth and development of the fetus in ways that have not yet b...