Collagen is the predominant protein in animal bodies, constituting approximately 30% of the total protein (Birk & Bruckner, 2005; Unlua et al. 2014). It is an extracellular matrix protein that can either directly or indirectly interact with cells to alter cellular activity. At least 27 different types of collagen have been indentified, correspondingly named types I to XXVII (Birk & Bruckner, 2005).
Structure
Collagen is characterized by the right-handed triple helical rod structure which is formed by three left handed helix polypeptide chain. Although the triple helical structure is the main characteristic of collagen, some globular proteins are indentified as collagen due to the repeating trilets and small triple helical rod (Prockop & Kivirikko 1995). Each polypeptide chain consists of repeating triplets, (Gly-X-Y), where X and Y are, with a high frequency, proline (Pro) and hydroxyproline (Hyp) repectively (Prockop & Kivirikko 1995 ; Ogawa et al. 2003). The glycine in every three amino acid is very essential. The small side chain of glycine allows the side chain from proline an...
Dystrophin is part of a complex structure involving several other protein components. The "dystrophin-glycoprotein complex" helps to anchor the structural skeleton (cytoskeleton) within the muscle cells, through the outer membrane (sarcolemma) of each cell, to the tissue framework (extracellular matrix) that surrounds each cell (Straube and Campbell, 1997). Due to defects in this assembly, contraction of the muscle leads to disruption of the outer membrane of the muscle cells and eventual weakening and wasting of the muscle
Not all attributes are obvious for every situation. The lion's share of instances of OI (conceivably 85-90 %) are created by a predominant change in a quality coding for sort I collagen (Types I, II, III, and IV in the accompanying rundown). Sorts VII and VIII are recently recognized structures that are acquired in a passive way. The qualities bringing about these two sorts have been recognized. Sorts V and VI don't have a sort 1 collagen change, however the qualities bringing about them have not yet been recognized. The general components of each referred to sort of OI are as per the
So far, various techniques have been used for reconstruction and regeneration of maxillary and mandibular bone defects. Autogenous bone grafting, guided bone regeneration (GBR), distraction osteogenesis and nerve transpositioning are among these regenerative techniques (1-8). Decision making for the treatment could be influenced by the type, size and location of the bone defects (2, 3, 9, 10). GBR had high success rate in treating small alveolar defects such as dehiscence or fenestration. Regenerative bony walls around the defect with ingrowing blood vessels can begin osteogenesis (11) larger bone defects with insufficient regenerative walls and an low quality avascular bed need varied amount of autogeneous bone graft from extra oral or intra oral donor sites, however, the patient may suffer from complications in donor site as well as bone graft resorption.(10, 12-15)
Repair after a muscle is damaged happens through the division of certain cells who then fuse to existing, undamaged muscle fibers to correct the damage. Different muscle types take different amounts of time to heal and regenerate after it has been damaged. Smooth muscle cells can regenerate with the greatest capacity due to their ability to divide and create many more cells to help out. While cardiac muscle cells hardly regenerate at all due to the lack of specialized cells that aid in repair and regeneration. In skeletal muscle, satellite cells aid in helping restoration after injury. Along with muscles, tendons are very important structures within the human body, and they to can be damaged. However, tendon repair involves fibroblast cells cross-linking collagen fibers that aid in not only reinforcing structural support, but also mechanical support as well (“Understanding Tendon Injury,” 2005). While quite different from muscle repair, tendon repair involves the similarity of reestablishing d...
Osteogenesis imperfecta, also known as “brittle bones disease,” is a rare genetic disorder that affects the body’s production of type I collagen, which is the major protein of the body’s connective tissue. Generally, people affected with OI either have too little of type I collagen, or the quality of it is poor. Collagen defects account for about 85%.1 However, proteins in the bones may be affected in some of the more uncommon forms of OI. Because of this defect, people with OI have fragile bones, which break easily without an apparent cause.
Protein have connection with amino acid to help in functions of: skin, muscle, hair and bones
n.d. - n.d. Peptides and Proteins. Proteins. Retrieved July 25, 2008, from http://www.cd http://www.cem.msu.edu/reusch/VirtualText/protein2.htm Ophardt, C. E. (2003).
The musculoskeletal system is comprised of bones, joints, cartilage, tendons, ligaments, fascia and muscles. Together these body parts work to establish a framework that is the musculoskeletal system. This framework is what gives the body its shape, form, and figure. It stabilizes the body as well as supplies the structural support. The musculoskeletal body features not only provide a framework for your body but allows your ability to create movement. These movements are monitored by the musculoskeletal components which then determine your degree of flexibility. Overall the amount of energy your body uses comes almost entirely from these musculoskeletal functions. Which makes sense because it
The cytoskeleton is made up of three different types of filaments, actin filaments, intermediate filaments and microtubules. Actin filaments are the thinnest, they are also known as microfilaments. They create a band under the plasma membrane, this gives strength to the cell and links transmembrane proteins such as cell surface receptors to cytoplasmic proteins. Intermediate filaments include keratins, lamins, neurofilaments and vimentins. Keratins form hooves, horns and hair and are found in epithelial cells. Lamins form a type of mesh that ‘stabilizes the inner membrane of the nuclear envelope’ (Biology Pages). Neurofilaments bring strength to the axons of neurons and vimentins provide mechanical support to cells – particularly muscles. The cytoskeleton is also involved in cell
The covalent structure of a protein is composed of hundreds of individual bonds. Because free rotation is possible around a good portion of these bonds, there are a very high number of possible conformations the protein can assume. However, each protein is responsible for a particular chemical or structural function, signifying that each one has a distinctive three-dimensional configuration. By the early 1900’s, numerous proteins had been crystallized. Because the ordered collection of molecules in a crystal can only form if all of the molecular units are the same, the discovery that proteins could be crystallized proved that even large proteins have distinct chemical structures. This deduction completely transformed the understanding of proteins and their respective functions. It is important to investigate how a series of amino acids in a polypeptide chain is translated into a three-dimensional protein structure. There are five general topics related to this process: the structure of a protein is determined by its amino acid sequence, the role of a protein is dependent on its unique structure, an isolated protein typically exists in a small number of stable forms, non-covalent interactions are the most important stabilizing forces in a protein structure, and there are structural patterns that aid in explaining and understanding protein architecture.
Keratin, this protein gives mechanical support to the body. It makes the outermost layer of human skin, hair, and nails, and the scales. hooves, and feathers of animals. It twists into a regularly repeating coil is called an alpha helix. Serving to protect the body against the environment, keratin is completely insoluble in water.
Anatomy is a study of the structure or internal workings of something and physiology is the branch of biology that deals with the normal functions of living organisms and their parts. A cosmetologist practice beautifying the face, hair and skin of their clients and a nail tech purpose is to take care of both finger and toenails.
“Fibroblast responses to variation in soft tissue mobilization pressure.” Medicine and Science in Sports and Exercise. April 1999: 531-5. Hargrove, Eugene C., ed. Animal Rights/Environmental Ethics Debate, Inc. Environmental Perspective.
There are four main levels of a protein, which make up its native conformation. The first level, primary structure, is just the basic order of all the amino acids. The amino acids are held together by strong peptide bonds. The next level of protein organization is the secondary structure. This is where the primary structure is repeated folded so that it takes up less space. There are two types of folding, the first of which is beta-pleated sheets, where the primary structure would resemble continuous spikes forming a horizontal strip. The seco...
Domains may be considered to be connected units, which are to varying extents independent in terms of their structure, function and folding behaviour. Each domain can be described by its fold. While some proteins consist of a single domain, others consist of several or many. A number of globular protein chains consist of two or three domains appearing as 'lobes'. In other cases the domains may be of very different nature- for example some proteins located in cell membranes have a globular intracellular or extracellular domain distinct from that which spans the membrane.