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Bacteria, viruses and prions are biological pathogens
Difference between a prion and a virus microbiology
Bacteria, viruses and prions are biological pathogens
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Viruses, bacteria, and prions are microscopic, living beings. All three can be found inside and outside hosts. Bacteria and viruses are more similar with each other than a prion with either one. None are even closely related, though. The three of them have different reproduction methods, structures, and choices of hosts. These are not the only differences by a long shot, but it is a start.
A virus is an infectious agent. It is very small in size. They cannot reproduce without the use of a host. A capsid surrounds the virus. The capsid is made of protein subunits. It has three main functions, first, to protect the nucleic acid within from digestion. Secondly, hold proteins that attach to certain host cells for reproduction. Lastly, to provide proteins that help the virus enter the host cell during penetration. The other main part of a virus is nucleic acid. This is DNA or RNA that holds the genetic material for protein synthesis.
Viruses have two different reproduction cycles, the lytic and lysogenic cycles. The lytic cycle has five stages: attachment, penetration, biosynthesis, maturation, and then, release. In attachment, the virus capsid uses its host specific proteins and combines with a receptor on the host cell. Then comes penetration, where the viral DNA is inserted into the host cell, through the receptor, past the membrane. Biosynthesis follows, viral components are synthesized and the host cell starts replicating the virus. After biosynthesis is maturation. In maturation the viral components assembly, meaning that all the virus structures come together to prepare for the next stage of release. Finally, there is release, where the new viruses leave the host cell to infect more cells. Some of the things different betwee...
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...ic wasting disease : Wsj." . Wisconsin State Journal , 28 Sept. 2013. Web. 16 Apr. 2014. .
• "Chickenpox: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, 2 Aug. 2011. Web. 16 Apr. 2014. .
• "Salmonella enterocolitis: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, 30 May 2012. Web. 16 Apr. 2014. .
• "Creutzfeldt-Jakob Disease Fact Sheet." : National Institute of Neurological Disorders and Stroke (NINDS). N.p., 16 Apr. 2014. Web. 16 Apr. 2014. .
Diagnosis of salmonellosis involves testing a sample of stool, as well as isolation from samples of tissue, blood, or urine. Since it is commonly mistaken for the flu and involves similar symptoms to other illnesses, the method of diagnosis for salmonellosis is pretty hard to come by. Most people with salmonellosis don’t seek treatment, so they’re never aware that they even had it. Since it is a foodborne pathogen, has a common route of infection via oral ingestion, and is found in food products that we consume on a daily
In the subsequent essay I will discuss and explain the relative function of the Prion protein. The Prion protein, also known as PrPC, ‘’is a membrane-anchored protein with two N-glycosylation sites and, although it is highly expressed in the nervous tissues, its physiological functions have yet to be well established’’ (Coordination Chemistry Reviews). PrPC/PrP is found in healthy brains in this form, and consists of 250 Amino Acids, yet after a simple misfolding in the secondary structure; this can alienate the PrP and forms PrPsc, which is the abnormal form of the Prion protein. The infectious agent PrPsc causes neuropathological changes in the brain, and instantly places the individual under the category of someone with the prion disease. PrPsc forms insoluble fibres and thus cannot be studied well using Nuclear Mass Resonance (NMR), and it is also more resistant to protease digestion. Furthermore, ‘’ The transmissible spongiform encephalopathies (TSEs) arise from conversion of the membrane-bound prion protein from PrPC to PrPSc, the latter being the scrapie form. Examples of the TSEs include mad cow disease, chronic wasting disease in deer and elk, scrapie in goats and sheep, and kuru and Creutzfeldt-Jakob disease in humans’’ (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904554/. 2014). The following diagram shows the conversion from PrPc to PrPsc:
Cytomegalovirus (CMV) is the most common virus in the United States that can infect almost any individual. Cytomegalovirus is also referred to as Herpesvirus-5, which belongs to a branch of Herpesviridae family. Herpesviridae has a spherical shape that contains four significant elements that are important to the viron. The four elements are the core, tegument, capsid and the envelope. Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae are three subfamilies which belong to Herpesviridae. Cytomegalovirus belongs to the Betaherpesvirinae family, which also include Muromegalovirus and Roseolovirus. The Alphaherpesvirinae subfamily includes Simplexvirus, Varicellovirus, Mardivirus and Iltovirus genera. The Gammaherpesvirinae subfamily contains Lymphocryptovirus and Rhadinovirus genera. The diameter size of the virus is based on each specific family; however, the core remains the same throughout the species, which contains single layer of double stranded DNA tightly condensed in the capsid. In the tegument component, there are 30 or more viral proteins that are shapeless that encompass the capsid. Out of the four major components, the tegument has the most poorly defined structure. On the other hand, the capsid is a well-defined structure that is an icosahedron, which is composed of 162 capsomeres, 12 of which are pentons and 150 are hexons (1). Last but not least, the liquid envelope surrounds the tegument with approximately 10 glycoprotein and cellular proteins. Each subfamily under the herpesviriade has its own arrangement between the liquid envelop and the tegument layer.
Abstract: Salmonella is a bacterium that causes one of the most common intestinal infections in the United States - Salmonellosis. The chance of contracting this disease is significantly high, and more and more people are suffering from the symptoms and complications of Salmonella. This paper will discuss about the disease itself, the current outbreaks that are related to this disease, preventions and the treatments.
The prion diseases that Chronic Wasting Disease is related to are Creutzfeldt-Jakobs disease found in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapies in sheep (3,4). These diseases are grouped together because they share certain characteristics such as long incubation periods, spongiform changes that are associated with neural loss, and cause failure to induce inflammatory responses (Chronic Wasting Disease Alliance).
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
“Salmonella Questions and Answers.” USDA Food Safety and Inspection Service. 20 Sept. 2006. 20 July 2008 .
"Bloodborne Pathogens : MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 09 Feb. 2014.
...ving things carry viruses in their cells. Even fungi and bacteria and inhabited by viruses and are occasionally destroyed by them. A virus makes copies of itself in a cell until eventually the cell gets pigged with virus and pops and the viruses spill out of the broken cell. If enough cells are destroyed, such as they do in the case of Ebola, the host dies. A virus does not "want" to kill its host. That is not in the best interest of the virus, because then the virus may also die, unless it can jump fast enough out of the dying host into a new host.
So as you can see Salmonella typhimurium is a serious microorganism that can create a lot of havoc if it gets inside of a person’s system and although there are many ways to diagnosis it, it must be diagnosed quickly or a person could end up in the hospital.
There is a lot that we still do not understand about prions. All cases of prion-caused diseases are terminal, and doctors are entirely helpless. Perhaps, in the future, a method of combating this pathogen will be discovered. Until that time comes though, prions remain essentially invulnerable to us. The only measures we can take in protecting ourselves from diseases caused by prions are purely preventative. Stricter food production monitoring, making sure no brain matter is distributed to the populace, and other ways to halt the spread of diseases. And yet, sometimes people just get CJD sporadically. Prion caused diseases are, essentially, a medical mystery.
Salmonella is one danger that has caused many effects to consumers. Walsh writes about one incident when an outbreak “from tainted peanuts that killed at least eight people and sickened 600,” (Walsh 167). This incident left many people asking the same question, how can we trust the food that we put into our bodies? Salmonella, a type of food poisoning caused by bacteria found on different food types has caused an epidemic because of its domino effect on food and our health. Once one factory is contaminated, that factory could be housing both crops and meat, which is then transferred to our supermarkets and on our dinner tables. ...
Creutzfeldt-Jakob Disease is an uncommon, deteriorating, consistently fatal brain disorder that is caused by prions. The symptoms of CJD are similar of Alzheimer’s but progress much faster. There are three variations of CJD, sporadic, familial, and acquired. All variations affect the brain the same way and have the same result of death. CJD is an untreatable and incurable disease.
Virus- An infectious agent found in virtually all life forms, including humans, animals, plants, fungi, and bacteria. Viruses touch us every day through water, food, physical contact, blood, animals, or even, the air you breathe. Although most are harmless, there are some that are not.... ...
Salmonella is also a bacterium that is widespread in the intestines of birds, reptiles, and mammals. It can spread to the human species a variety of different ways; through foods or animal origins. Some examples of food involved in outbreaks are eggs, poultry and other meats, raw milk and chocolate. The illnesses it causes are typically fever, diarrhea, and abdominal cramps. In people with poor underlying health or weakened immune...