Sickle Cell Disease Association of America, Inc.. Retrieved January 19, 2014, from http://www.sicklecelldisease.org/ What Are the Signs and Symptoms of Sickle Cell Anemia?. (n.d.). NHLBI, NIH. Retrieved January 22, 2014, from http://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs.html What Is Sickle Cell Anemia?. (n.d.).
Sickle cell anemia primarily affects people with African, Mediterranean, Middle Eastern, and Indian ancestry (Learn genetics, 2010; NHLBI, n.d.; Vorvick et al., 2010). Sickle cell anemia occurs when a person inherits two sickle cell gene, one from each parent, that cause the red blood cells to change and become crescent shaped. The underlying problem involves hemoglobin, a component of the red blood cells. Hemoglobin is a protein molecule in red blood cells that carries oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lungs (Nabili, 2008, para. 1).
“Hereditary Spherocytosis.” http://emedicine.medscape.com/article/206107- overview. January 10, 2012. November 19, 2013 http://grh.nlm.nih.gov/condition/hereditary-spherocytosis/. Hereditary Spherocytosis. November 18, 2013 http://www.seattlechildrens.org/medical-conditions/heart-blood-conditions/hereditary -spherocytosis-symptoms/.
The sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell have red blood cells that have mostly hemoglobin's, Sometimes these red blood cells become sickle-shaped or crescent shaped and have trouble going through small blood vessels. When sickle-shaped cells block small blood vessels, less blood can get to that part of the body. Tissue that does not get a normal blood flow eventually becomes damaged.This is what causes the problems of sickle cell disease.As to this day there is really no cure for sickle cell disease.Red blood cells take oxygen from the air we breathe into our lungs to all parts of the body. Oxygen is carried in red blood cells by a substance called hemoglobin(Hemoglobin – is the main substance of the red blood cell.
(2014, January 2). Retrieved May 18, 2014, from http://www.mayoclinic.org/diseases-conditions/thalassemia/basics/complications/con-20030316 Thalassemia. (2012, February 7). Retrieved May 18, 2014, from http://www.nlm.nih.gov/medlineplus/ency/article/000587.htm
Professor Whitney also stated that the plasma membrane which is a part of a cell is made up of proteins. This just shows how proteins are important in our body. However, Hemoglobin protein functions as an oxygen carrier, gives color to red blood cells, returns carbon dioxide to lungs and reacts as a buffers by resisting the ph in our bodies. All this is affected when a person has sickle cell genes because the hemoglobin becomes defective and abnormal; in addition sickle cell anemia lowers proteins in our body. This can make the person to suffer from various diseases which are caused due to lack of proteins in the body.
Retrieved March 10, 2014, from Medicine Net website: http://www.medicinenet.com/turner_syndrome/article.htm National Institute of Health. (2008, May 14). Klinefelter Syndrome. Retrieved from Medicine Net.com website: http://www.medicinenet.com/ klinefelter_syndrome/page2.htm WebMD Public Information from the National Cancer Institute. (2014, February 25).
Topic: Thalassemia disorder Thalassemia is an inherited co-dominant blood disease. It is characterized by reduced synthesis of the hemoglobin and less red blood in children affected by this disorder. Hemoglobin is the means through which red blood cells carry oxygen in our body. We need two forms of globin genes to make beta globin chains in our body, one from each globin gene. If one or two of these genes are defective, it produces beta thalassemia which is the less severe form of this disease.