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Tacrolimus Case Study

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Acute Tacrolimus Toxicity Successfully Treated with Phenytoin Tacrolimus is an integral part of immunosuppression following solid organ transplantation. We present a case of acute tacrolimus toxicity in a renal transplant recipient successfully treated with phenytoin. A 55-year old male with history of end-stage renal disease due to tuberous sclerosis and polycystic kidney disease who had undergone a living related renal transplant 17 years ago was transferred to our facility for evaluation of acute kidney injury (AKI). The patient was admitted to a psychiatric facility for suicidal ideations and had recently been initiated on multiple psychotropic drugs including haloperidol, quetiapine, benztropine, hydroxyzine, citalopram and fluoxetine.
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