Summary of: Apoptosis in Human Hepatoma HepG2 Cells Induced by Corn Peptides and Its Anti-tumor Efficacy in H22 Tumor Bearing Mice

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Jiang-Tao Li, Jiu-Liang Zhang, Hui He, Zhi-Li Ma, Zhi-Kui Nie, Zhen-Zhen Wang, and Xiao-Gen Xu are affiliated with the College of Food Science and Technology, Huazhong Agricultural University & Key Laboratory of Environment Correlative Dietology, and the Ministry of Education, all in China. Their study of corn peptide effects on liver tumors in mice was funded by a grant from China’s National Natural Science Foundation and National “863” Program. They undertook this study to examine the effects of plant-derived chemicals on cancer. Cancers can be a result of any combination of dietary insufficiency, environmental factors, and/or genetic components. However, up to 95% of cancers are thought to be the result of diet and other lifestyle factors rather than the result of genetic factors (Bhanot et al 2011). The authors recognize this fact and that there is a proliferation of naturally based products to boost immune function and combat tumor growth and development. Corn proteins (CPs) are widely and readily available as they are by-products of the expansive corn products market. Because previous work with CPs had shown positive physical affects (such as lowering blood pressure and mitigating the harmful effects of alcohol on the liver), the authors chose to examine how CPs might modulate tumors and the immune systems of mice.
The corn proteins were prepared by separating them out of corn gluten meal using an ultra-filtration method. The CPs were lyophilized (sterilized powder) for use in the mouse experiment. BALB/c mice were used to grow H22, a type of liver tumor analogous to the human liver tumor HepG2. The BALB/c mice are a line of inbred mice that are not naturally prone to tumors (Festing 1998). The H22 cells were injected into ...

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...results seem promising in mice, mice are not primates and certainly not humans. This study can serve as a jumping off point for further experimentation.

Works Cited

Bhanot, A., Sharma, R., & Noolvi, M. N. (2011). Natural sources as potential anti-cancer agents: A review. International Journal of Phytomedicine, 3, 1-18.

Festing, Michael FW. "BALB/c". (1998) Inbred Strains of Mice. Jackson Laboratory.

Fulda, S., & Debatin, K. (2006). Extrinsic Versus Intrinsic Apoptosis Pathways In Anticancer Chemotherapy. Oncogene, 25(34), 4798-4811.

Li, J., Zhang, J., He, H., Ma, Z., Nie, Z., Wang, Z., et al. (2013). Apoptosis in human hepatoma HepG2 cells induced by corn peptides and its anti-tumor efficacy in H22 tumor bearing mice. Food and Chemical Toxicology, 51, 297-305.

Tortora, G. J., & Funke, B. R. (2013). Microbiology: an introduction (11th ed.). Boston: Pearson.
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