Stereocilia

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Crazy Idea We are all born with a fixed number of hair cells. The death of these hair cells as mentioned earlier is the cause of hearing loss. The reason is simply due the fact that the hair cells facilitate the process of turning mechanical force or sound pressure into an electric signal, which is sent to the brain. If there are fewer hair cells the response to stimuli is not as efficient and therefore cannot detect sounds proficiently. To solve this problem I would replace the hair cells with bird hair cells via microsurgery. Hair cells in birds regenerate after damage and therefore would ideal for ensuring that hearing won’t diminish overtime after noise exposure. A study done on quails in [9] to figure out whether regeneration of stereocilia on hair cells is related to the age at which overstimulation occurs and to learn how the regeneration process occurs. First they figured out whether regeneration can occur in adult birds by exposing them to a 115 dB tone for 12 hours. The birds survival time varied form 0 to 60 days and the number of hair cells damaged were recorded. They reported that after 10 days the number of hair cells had decreased mainly in the basal and middle part of the cochlea. In birds that lived up to 30 days after the acoustic trauma the hair cell loss was not as severe. Similarly to the 10 day birds the mainly region of damage was located in the middle of the cochlea. Furthermore the percentage of dead/loss hair cells was 70% and 31% in the 10 day and 30 day birds respectively. In birds that were allowed to live longer than 30 days they saw progression towards completely recovered hair cells. These results clearly show that in adult birds recovery is possible after acoustic trauma and that this process... ... middle of paper ... ... physiological function in the tissue. The first step in the regeneration process is the conversion of supporting cells into hairs without mitosis and is known as direct transdifferentiation [11]. The supporting cells go through a set of morpho-logical and molecular changes to gain the sensory properties of hair cells. Supporting cells are converted to hair cells in roughly 2-3 days. 30-50% of the new hair cells are formed via transdifferentiation but it is still not clear when they new converted hair cells become functional or their impact its has on regenerations cells in the early stages[11]. This study shows that there are two main methods for regeneration of hair cells: proliferation and transdifferentiation. Works Cited Feathers and fins: Non-mammalian models for hair cell regeneration Heather R. Brignulla,⁎, David W. Raiblea,b, Jennifer S. Stoneb,c

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