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smallpox pathogenicty
smallpox pathogenicty
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Small Pox
Ä) Who; introduced to Europe by Mary Montagu
B) Where; China and India
C)When; 4th century China, 7th century India
II. History of the disease:
(include recent research and development of cures and treatments.
U.S and Russia will not destroy there cultures of small pox for fear of a bio war. Scientists must decide if they want to destroy the last remaining viles of the small pox virus--amid claims to human achievememt, arrogance
III. Causes: Usually passed between two people through droplets from the nose or mouth which reproduced in the lymphoid tissue.
IV. Symptoms: After about a 12 day period, victims usually developed high fevers, chills, nausea, aches, and a rash that would fill with pus and sometimes swelled severely.
V. Treatments : Most of the victims died, if not scabs formed and eventually fell off leaving scars and perment pits in the flesh. Some victims went blind.
VI. Cure (if curable) There is no specific treatment for small pox
VII. Updated info; The World Health Organization has declared the small pox virus Free.
Hemorrhagic smallpox; about one hour before death. Thick hemorrhage occuring in the mouth and from the lungs. Smallpox virus is extremely contagious in the air
smallpox
also called VARIOLA, one of the world's most dreaded plagues until 1977, when it was declared eradicated. The disease was described as early as 1122 BC in China and is referred to in ancient Sanskrit texts of India. The mummified head of the Egyptian pharaoh Ramses V (died c. 1156 BC) bears evidence of the disease.
Smallpox is an acute infectious disease caused by a virus, characterized by fever and, beginning about two days later, an eruption that, after passing through the stages of papule, vesicle, and pustule, dries up, leaving more or less distinct scars. The characteristic eruption may be so profuse as to be confluent, especially on the face, or so scanty that the lesions are missed altogether.
Modifications, both toward fewer lesions and toward their being more superficial, may occur either naturally or because of vaccination that was not recent enough to give complete protection against the disease. With nearly complete vaccinal protection, few lesions will appear; but even if vaccination has been effected many years before, smaller and more superficial lesions are the rule in cases in which an unvaccinated person would have a severe attack. Such superficial lesions are also characteristic of the naturally occurring mild strains of the disease (variola minor).
Besides the characteristic focal eruptions (papule to vesicle to pustule to scab to scar), there is sometimes a toxic eruption during the initial fever, before the appearance of the true smallpox rash.
Carmichael, Ann. "Plague." Europe, 1450 to 1789: Encyclopedia of the Early Modern World. Ed. Jonathan Dewald. Vol. 4. New York: Charles Scribner's Sons, 2004. 490-493. Gale Virtual Reference Library. Web. 25 Feb. 2014.
This summer we had an opportunity to dive into the world of bioweapons, through Richard Preston’s novel The Demon in the Freezer. His book explored the colorful world of smallpox and its use as a biological weapon. Earlier this week we were graced with this authors present for an ACES event. He discussed some of the found topics in his book such as animal testing, what small pox is, and even its eradication. One of the great things we had the chance of vocalizing were our many opinions on the gloom associated with this intriguing disease.
Symptoms, which include diarrhea and abdominal pain, usually begin two to eight days after a person has been exposed to the bacteria and resolve within a week.
In closing, the variola virus affected a great amount in that era including, military strategy, trade, and native populations. Elizabeth A. Fenn’s book Pox Americana: The Great Smallpox Epidemic of 1775-82 sheds light on a significant aspect of that era that had not been given proper credence beforehand. She also illuminated the effect of smallpox when it came to race and social status. With regard to race, smallpox decimated much of the non European populations partly because of their lack of an innate immunity to that virus and Europeans lack of regard for those of a different race. Fenn’s argument on social status showed how the poorer strata’s of society suffered more severely from the variola virus because of their lack of finances to get inoculated; thus, the poor often suffered a worse strain of the virus which often lead to death.
After an incubation period of five to ten days, or as long as 21 days, numerous symptoms can be observed. The symptoms come in two stages. The first stage consists of common cold symptoms such as sneezing, runny nose, low-grade fever, and a mild cough. It is during this time that the disease is most contagious, and it lasts from one to two weeks.
After a series of biochemical tests and evaluation to determine several unknown bacteria, the bacterium Yersinia pestis was chosen to report. The discovery of Y. pestis dates back to 1894 by French/Swiss physician and bacteriologist named Alexandre Yersin. The name Yersinia pestis is synonymous with its more common name, the plague. Y. pestis is known to infect small rodents such as mice and rats, but is transmitted to humans through the bite of an infected animal or flea. Although this bacterium is known to still cause illness today, it is infamous for three pandemics that occurred in earlier centuries. According to the Centers for Disease Control and Prevention, the first recorded pandemic occurred in 541 A.D. and is known as the Justinian Plague. The second pandemic originated in China in 1334 and has received the egregious name the “Black Death.” Finally, the third outbreak took place in the 1860’s and is known as the Modern Plague. It wasn’t until the end of the Modern Plague that scientists discovered the causative agent and mode of transmission of the Yersinia pestis bacterium.
In the book Frankenstein Virtue is found at the margins of society more often than at its center. If this is so, Victor Frankenstein's Monster is a real find! His creature is an isolate of great sensitivity, kindness, and insight. In reality the Monster was not a bad person. He is quite distress and asks Victor, "What was I? Of my creation I was absolutely ignorant: but I knew that I possessed no money, no friends, no kind of property.... Was I then a monster, a blot upon the earth from which all men fled, and whom all men disowned?" (Shelley 89). Finally the creature makes clear his great need: he is lonely, one of a kind, and unloved. He has learned the importance of position, family, and property. It also seems that the Monster was quite lonely and did not have any friends. He is unaccepted even by his own creator. No offence that the creature was ugly but it was not his fault because he did not created him. There are things to enjoy in the movie "Mary Shelley's Frankenstein", directed by the Kenneth Branagh. Branagh has used film techniques in such a way that it shows the sadness and loneliness of the monster. Yet the director interested in technical effects could highlight key ideas. For example, the excitement of opening in the frozen north, with one figure moving across the ice and receding into the distance while another suddenly appears hundreds of miles from land, could hold the attention of the audience. The relationship between isolated figures on a vast expanse of ice could serve as a poetic leit-motif in the film and retain a significant element of the novel. The cold and sterile elements assume greater meaning than a senselessly rampaging creature engulfed by fire. The monster wanted love from his creator and from the world. He did not have any friend in the world to share his sorrow. When the monster meets the blind father De Lacey, he realized his chance for friendship relied more on hearing than sight. The old man's blindness surely overcome human prejudice against physical ugliness, De Lacey commiserated with the Monster and graciously offered him help and friendship. But the reaction of the old man's sighted family upon seeing the Monster desperately clinging to their father deemed him a fiendish threat and the creature found himself drive out of the society of cottagers.
He toils endlessly in alchemy, spending years alone, tinkering. However, once the Creature is brought to life, Frankenstein is no longer proud of his creation. In fact, he’s appalled by what he’s made and as a result, Frankenstein lives in a perpetual state of unease as the Creature kills those that he loves and terrorizes him. Victor has realized the consequences of playing god. There is irony in Frankenstein’s development, as realized in Victor’s desire to destroy his creation. Frankenstein had spent so much effort to be above human, but his efforts caused him immediate regret and a lifetime of suffering. Victor, if he had known the consequences of what he’s done, would have likely not been driven by his desire to become better than
In order to understand the history of smallpox one first has to understand how diseases like it evolve. Much like other species, diseases that survive in the long run are the microbes that most effectively reproduce and are able to find suitable places to live. For a microbe to effectively reproduce, it must "be defined mathematically as the number of new infected per each original patient." This number will largely depend on how long each victim is able to spread the virus to other victims (Diamond, 198).
From 166 A.D. to 180 A.D., The Antonine Plague spread around Europe devastating many countries. This epidemic killed thousands per day and is also known as the modern-day name Smallpox. It is known as one of deadliest plagues around the world.
It was spread very slowly and less broadly than other viral illnesses which took a long time to identify the infection in the first two weeks. Infection of smallpox started to grow between 7 to 10 days when the scabs formed into bruises. The signs and symptoms of this disease include high fever, widespread rashes, redness, muscle pain, headache, common cold, vomiting, nausea and many more. Consequently, the virus was found in the bone marrow along with bloodstream in huge numbers. There are different types of the smallpox disease with other classifications.
In the 1630s, another small pox epidemic broke out in what is modern day Massachusetts. After this epidemic, small pox would spread rapidly all across the New World killing off almost 90% of the Native peoples. It is said that this disease killed so many so rapidly that no one had the strength to even bury the dead. The Natives had such weak immune systems that sometimes the small pox
During one of his earlier apprenticeships, Jenner noticed milkmaids with a disease called cowpox. Cowpox is a close relative to smallpox and is only mild in humans. Pustules appear on the hands and a basic cold is also brought on. At Jenner’s young age he was able to link these two viruses together and come up with a theory for immunization. In 1796, while still attending medical school, Jenner decided to test this theory between smallpox and cowpox. He used a dairymaid, who was a patient of his named Sarah Nelms, who had contracted cowpox and had ripe pustules on her hands. Jenner realized this was his opportunity to test someone who had not contracted smallpox yet. He picked an eight-year old boy named James Phipps to use as his test subject. He scraped open a spot of James' arm and rubbed in a dissected piece of Sarah Nelms pustule into the open wound. A couple days later James became ill with cowpox but was well again within a week. This test proved that cowpox could be spread between humans as well as cows. Jenner's next test would be if the cowpox virus gave James immunity against smallpox. On July 1st of 1796, Edward Jenner obtained an infected smallpox pustule and scratched the virus filled pus into James' arm. This technique of placing a virus into a patient is called variolation. James Phipps did not develop smallpox within the
It was a bubonic plague that came from Asia and spread by black rats infested with fleas. The plague spread like a wildfire because people who lived in high populated areas were living very close to each other and had no idea what was the cause of the disease or how to cure it. The signs of the “inevitable death” where blood from the nose, fever, aching and swellings big as an “apple” in the groin or under the armpits. From there the disease spread through the body in different directions and soon after it changed into black spots that appeared on the arms and thighs. Due to the lack of medical knowledge, no doctors manage to find a remedy. Furthermore a large number of people without any kind of medical experience tried to help the sick but most of them failed “...there was now a multitude both of men and of women who practiced without having received the slightest tincture of medical science - and, being in ignorance of its source, failed to apply the proper remedies…” (Boccaccio). The plague was so deadly that it was enough for a person to get infected by only touching the close of the
After Frankenstein discovered the source of human life, he became wholly absorbed in his experimental creation of a human being. Victor's unlimited ambition, his desire to succeed in his efforts to create life, led him to find devastation and misery. "...now that I have finished, the beauty of the dream had vanished..." (Shelley 51). Victor's ambition blinded him to see the real dangers of his project. This is because ambition is like a madness, which blinds one self to see the dangers of his actions. The monster after realizing what a horror he was demanded that victor create him a partner. "I now also began to collect the materials necessary for my new creation, and this was like torture..." (Shelley 169). Victor's raw ambition, his search for glory, has left him. His eyes have been opened to see his horrible actions, and what have and could become of his creations. As a result, Victor has realized that he is creating a monster, which could lead to the downfall of mankind. His choice is simple, save his own life or save man.