Sickle Cell Diseases (SCD)

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Sickle cell diseases (SCD) are diseases which are caused due to disorder of hemoglobin in hour body. Hemoglobin is a protein that transports oxygen through the red blood cells. People with sickle cell diseases have hemoglobin S which shapes the red blood cells in a sickle shape. Sickle cell diseases cause painful vaso-occlusive crises (VOC), stroke, acute chest syndrome, splenic sequestration, chronic pulmonary and renal dysfunction, and a vascular necrosis of the joints. It also causes physical and psychological stress of illness. Sickle cell diseases are treated in many ways, people with SCD undergo many optional therapies which include, chronic blood transfusion, hydroxyurea and allogeneic hematopoietic cell transplantation (allo-HCT), this…show more content…
Cell plays a big role in our body. According to Campbell biology, a cell is a basic unit of life and all organisms are made up of cells. The book states that some complex organisms like plants and animals are multicellular. Furthermore, cells plays different functions in living things. Cells transport proteins to different parts of the body, they transport waste product, Provide energy in form of ATP, protects our body by making sure that blood is not exposed to germs. Cell are also composed of nucleus which contains the DNA used for reproduction and protein formation. The normal red blood cells are round in shape to increase the surface area for oxygen transportation whereas sickle cell anemia cells are sickle shaped and stiff. This makes the cells unable to carry oxygen because the surface area is reduced in size. Furthermore, when the cells becomes sickle they only last for a couple of days and die. This makes the cell unable to move and they stick in the small blood vessels; as the result, body tissues and organs don’t receive enough oxygen required to stay healthy. This is why many people affected by sickle cell anemia have difficulty in breathing, feel weak and tired. It also causes the damage of organs like lungs and liver. Sickle cell anemia affect respiration system in the body. Even though the study in HRQoL is not promising that people with sickle cell anemia will have…show more content…
The main protein which is affected by sickle cell is hemoglobin. The normal hemoglobin in a normal person is hemoglobin A whereas in sickle cell anemia the red blood cells contains abnormal hemoglobin which is hemoglobin S. In correlation with hemoglobin proteins affected by sickle shaped, Professor Whitney talked about the functions and structure of protein. Proteins act as a building blocks in our body. Proteins are also considered as a source of energy; they act as transport carriers and proteins control metabolisms and many cell function. Professor Whitney also stated that the plasma membrane which is a part of a cell is made up of proteins. This just shows how proteins are important in our body. However, Hemoglobin protein functions as an oxygen carrier, gives color to red blood cells, returns carbon dioxide to lungs and reacts as a buffers by resisting the ph in our bodies. All this is affected when a person has sickle cell genes because the hemoglobin becomes defective and abnormal; in addition sickle cell anemia lowers proteins in our body. This can make the person to suffer from various diseases which are caused due to lack of proteins in the body. This is why many researchers of HRQoL are doing more research on how to treat the sickle cell diseases. People with sickle cell anemia fail to function in their day to day lives due to the pain they pass through HRQoL gives people choice if
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