Severe Combined Immunodeficiency Disorder (SCID) is a rare condition in which those affected have little to no immune system. This is because “some of the cells in the immune system that fight infections (T cells and B cells) are missing or do not work well” (Puck). As a result, they are extremely susceptible to a wide variety of infections from viruses, bacteria, germs, etc. “There are about 100 different types of SCID (Puck).” The two most common types are X-SCID and ADA SCID. X-SCID is caused by a mutation in the X chromosome. Since this is the case, it is more likely for males to get this disorder since they have only one X Chromosome. A female has to get the deformity on both of their X chromosomes to be affected. If a female gets only one of their X chromosomes affected, then they become a carrier of the disorder and are not affected. Specifically the gene Il2RG is affected which is located at the locus xq13.1 on the X-chromosome. This region normally controls the encoding of a protein that constructs a receptor called interleukin-2. Also it “creates a key part of a receptor on the surface of a lymphocyte which, when activated by chemical messengers called cytokines, transmits information that directs lymphocytes to mature, proliferate and mobilize to fight infection” (Green). The purpose of this receptor is to allow T cells and B cells to communicate with each other. When the mutation is present, T cells and B cells cannot communicate with each other; therefore, cause the immune system to be unaware of invading pathogens. The body can now not fight off infections and is rendered defenceless. X-SCID is X-linked recessive which means it is inherited via the X chromosome and can only be recessive in females because they have ...
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...Possible Due to UCSF Research." University of California, San Francisco. N.p., 21 Mar. 2011. Web. 5 Jan. 2014. .
Puck, Chan K.. "Severe Combined Immunodeficiency (SCID)." Severe Combined Immunodeficiency (SCID). N.p., n.d. Web. 3 Jan. 2014. .
Schwartz, MD, MPH, Robert A. "Pediatric Severe Combined Immunodeficiency ." Pediatric Severe Combined Immunodeficiency. N.p., 6 Feb. 2013. Web. 27 Dec. 2013. .
"Weakened Immune System." - Symptoms, Diagnosis, Treatment and Information. N.p., 6 Dec. 2013. Web. 5 Jan. 2014. .
ED. Mayo Clinic Staff -. Mayo Foundation for Medical Education and Research, 05 Jan 2012. Web. The Web.
In the book it says "They can spend a whole lifetime worrying whether they 're carriers, and then we come along and offer them a test. Recessives and X-linked. Look what they 're doing with fragile-X nowadays. And cystic fibrosis. Just imagine the commercial possibilities if you can design and patent a probe for something like Gaucher 's disease...(69)" Recessive traits is the phenotype is seen only a homozygous recessive genotype for the traits of the interest is present. The booked talked about two of three diseases that are most common in the Ashkenazi Jewish population. The first one is Cystic fibrosis which is an inherited life-threatening disorder that effects the lungs and the digestive system. The other one mention in the book that wasn’t mention in class was Gaucher 's disease. Gaucher 's disease is a build up of fatty substances in your organs, usually in you spleen and liver. Which causes them to become bigger affecting their function. The last one that we learned in class was Tay-Sachs disease, which is a rare inherited disorder that destroys nerve cells in the brain and spinal
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
McMillan, Julia A., Ralph D. Feigin, Catherine DeAngelis, and M. Douglas Jones. Oski's Pediatrics, Principles & Practice. Williams & Wilkins, 2006.
Vorvick, Linda, Jatin Vyas and David Zieve. "Gangrene." 24 August 2011. MedLine Plus. 20 November 2013 .
Poliomyelitis is a dangerous viral disease which can lead to either partial or full paralysis of the human body. This infectious disease was a worldwide epidemic with more than twenty thousand cases reported throughout the world. It was only until 1955 when the Salk inactivated polio vaccine (IPV) was introduced which very successfully started supressing the disease. This disease is affiliated with the enterovirus subgroup of ‘Picornaviridae’ family. It is classified as three serotypes: PV1, PV2 and PV3. The infection is sprea...
Weakened immune systems are where you body has a harder time fighting sicknesses and illnesses. So, with a weakened immune system it would be harder to stay healthy and not sick.
6th ed. of the book. Stanford, a.k.a. The Science of Science, 2006. Print.
Seattle Education Project. (2013, November). STEP: The Immune System - An Overview, [Online]. Available: http://www.thebody.com/step/immune.html [11/12/14].
... Medicine. 3rd ed. Vol.3. Detroit: Gale, 2006.2139-2141. Gale Virtual Reference Library. Web. 3 Apr. 2014.
... middle of paper ... ... 14 Nov 2011.. http://web.ebscohost.com/lrc/detail?vid=4&hid=110&sid=fef50b1c-4aba-40fd-83b1- 583a32991f55@sessionmgr110&bdata=JnNpdGU9bHJjLWxpdmU=> Edrich, Matthias. The.
Iannelli, Vincent. The “Interview with a Pediatrician.” About.com. Pediatrics. September 30, 2012.
Kanwar, V.S. (2013, Sep 16). Diseases & Conditions - Medscape Reference. Pediatric Acute Lymphoblastic Leukemia. Retrieved January 13, 2014, from http://emedicine.medscape.com/article/990113-overview#a0156