The age of rapid and modern development has brought us into a lifetime filled with a whole new array of lifestyle choices that can be made. However, these developments have led to an increased sedentary lifestyle. In addition, jobs have become more demanding causing more work-related stress. These are just few of the problems which have led to one of the biggest consequences of the developing lifestyle in regards to health, an increased prevalence in hypertension. The Centre of Disease Control and Prevention (CDC) reports a third of the adult population suffer from hypertension in the United States itself (Fang et al., 2013). In this essay, the problem of hypertension will be highlighted as well as the development of treatments against it, more specifically, the development of angiotensin converting enzyme (ACE) inhibitors.
Hypertension is known as the precursor to many major life-threatening diseases and can also lead to deadly instances of heart attacks and strokes. It does so by hampering blood flow to vital organs and increasing the amount of plaque build-up in blood vessels (Patlak, 2004). There have been several different treatments that have been developed over the years in an effort to tackle the disease. Among the drugs used to treat hypertension are diuretics, beta-blockers and calcium channel blockers (Patlak, 2004). These drugs work by inhibiting the function of certain aspects of the body involved in the regulation of blood pressure. For example, diuretics were developed to increase the absorption of sodium and other salts into the urine by inhibiting carbonic anhydrase (Kenny, 2014; Patlak, 2004). This reduces blood volume, therefore decreasing blood pressure (Kenny, 2014). However, diuretics have been linked to hig...
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Cardiovascular agents are used to treat the heart, circulatory, and vascular system. Each Sub-Class has a unique active ingredient that targets the issues that our body cannot fight with alone. Patients who have one or more cardiovascular conditions such as CHF, hypertension and an arrhythmia may be taking multiple medications for each condition. There are multiple subclasses that I will be discussing. Even though they all are used for the cardiovascular system, they do target different areas.
Renin angiotensin system activation: Because of decreased blood flow to the kidneys the compensatory mechanisms activate to hold on to sodium and water. When the Blood flow is decreased Angiotensin II is released causing vasoconstriction
High Blood Pressure is anything that alters in peripheral vascular resistance, heart rate, or stroke volume that affects systematic arterial blood pressure. Long term effect of high blood pressure are serious and can cause heart attacks, strokes, kidney failure, and retinal damage. Hypertension is another medical word that substitutes the meaning of high blood pressure. It is known as the “silent killer” because it does not create any symptoms. The most common reason for high blood pressure is arteriosclerosis. Arteriosclerosis is the thickening and hardening of the walls of the arteries, occurring in old age. Four control systems have a job in maintaining blood pressure. These are the arterial baroreceptor and chemoreceptors’ system, regulation of body fluid volume, the renin- angiotensin system, and vascular autoregulation. Primary hypertension mostly occurs from a defect or malfunction in some or all of these
Cardiovascular Diseases (CVD) are the currently the leading cause of death globally for both men and women accounting for 21.9 per cent of total deaths and is projected to increase to 26.3 per cent by 2030 . Statins are the treatment of choice for the primary and secondary prevention of cardiovascular disease and in the management of hypercholesterolaemia because of their proven efficacy and safety profile. Evidences are showing their effectiveness in reduction of cholesterol synthesis and number of pleiotropic effects, which may be cholesterol dependent and cholesterol independent. The present review focus on the origin, properties and effects of statins on endothelial function ( non lipid action of statins) through the increase of endogenous production of NO in different pathways.
Yung,, L.M., Laher, I., Chen, Z.Y., Huang, Y. and Leaung , F.P. (2009) Exercise, Vascular Wall and Cardiovascular Diseases. Sports Medicine. Vol. 39, No. 1: 45-63
Blood pressure is a measurement of the force against the walls of your arteries as your heart pumps blood through your body. Hypertension is another term used to describe high blood pressure. This common condition increases the risk for heart disease and stroke, two leading causes of death for Americans. High blood pressure contributed to more than 362,895 deaths in the United States during 2010. Approximately 67 million persons in the United States have high blood pressure, and only half of those have their condition under control. An estimated 46,000 deaths could be avoided annually if 70% of patients with high blood pressure were treated according to published guidelines (Patel, Datu, Roman, Barton, Ritchey, Wall, Loustalot; 2014).
Hypertension can be defined as a force exerted against the wall of blood vessels. However, high blood pressure occurs when there is high pressure at the time of ventricle contraction during the systolic phase against decrease contract during diastolic phase as the ventricles relax and refill. This can be recorded as systolic over diastolic in millimeters of mercury. (Wallymahmed, M. 2008).
Whether it is Lipitor being used to lower cholesterol or aspirin to lower blood pressure, until the present, cardiovascular and heart diseases have been tackled by a variety of medications that address its various risk factors. However, this strategy focuses on secondary and tertiary prevention instead of heart diseases’ underlying causes. Yes, diabetes mellitus and hypertension have a concrete proven link to heart disease, but addressing them with medication only masks them and does not address the root of the problem.
As many as 73 million Americans have high blood pressure. Of the 1 in every 4 adults wi...
Hypertension is one of the major risk factors for the development of cardiovascular diseases including stroke and may also have a role in the development of vascular cognitive impairment and vascular dementia [1, 2]. Angiotensin I-converting enzyme (EC 3.4.15.1; ACE) plays an important role in the rennin-angiotensin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II [3-6]. ACE converts an inactive form of decapeptide, angiotensin I, to a potent vasoconstrictor, octapeptide, angiotensin II, in addition; since the ACE is a multifunctional enzyme it also catalyzes the degradation of bradykinin, which is known as a vasodilator [4, 7]. Therefore, inhibition of ACE activity leads to decrease in the concentration of angiotensin II and increases the level of bradykinin; consequently reduce blood pressure [8].
" Journal of Clinical Hypertension 13.5 (2011): 351-56. EBSOHost.com - a. Web. The Web.
Cardiovascular disease (CVD) and chronic kidney disease (CKD) closely parallel the obesity and insulin resistance epidemic. Current U.S. estimates project 70 million obese adults and an additional 70 million with hypertension and/or type II diabetes (28, 42, 45). More so, the National Health and Nutrition Examination Survey (NHANES), suggest a graded and continuous relationship exists between prevalent hypertension and increasing body mass index (BMI); a metric that is closely associated with insulin resistance and self-identified type II diabetes (8, 34).
Hypertension is a developing problem worldwide，associated with an increased risk of cardiovascular morbidity and mortality. In 2020, the world population will be approximately 7.8 billion people, and there will be 1 billon people who may be affected by hypertension (Tomson & Lip, 2005). One in three adults in the United States has high blood pressure. According to the report “Health, United States, 2010 with Special Feature on Death and Dying,” the prevalence of hypertension among adults 20 years old or older increased from 24% to 32% during 1988-1994 and 2005-2008. The African-American population has a higher prevalence of this health condition than white Americans do. In 2005 to 2008, the prevalence of hypertension among black males (41.4%) was more than 10%, compared to white males at 31.5% of the population. The hypertension rate of black females was more than twice that of white females. The death rate from hypertension among black males was 51.8 per 100,000, and among black females was 40.4 per 100,000; however, the morta...
Vicki is a 42-year-old African American woman who was diagnosed with Hypertension a month ago. She has been married to her high school sweetheart for the past 20 years. She is self-employed and runs a successful insurance agency. Her work requires frequent travel and Vicki often has to eat at fast food restaurants for most of her meals. A poor diet that is high in salt and fat and low in nutrients for the body and stress from her job are contributing factors of Vicki’s diagnosis of hypertension. This paper will discuss the diagnostic testing, Complementary and Alternative Medicine treatments, the prognosis for hypertension, appropriate treatment for Vicki, patient education, and potential barriers to therapy that Vicki may experience.
(2013, July 8). Trauma Emergencies. Retrieved from https://ambulance.qld.gov.au/docs/09_cpg_trauma.pdf renin-angiotensin system. (2014). In Encyclopaedia Britannica.